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Gene Review

TACC1  -  transforming, acidic coiled-coil...

Homo sapiens

Synonyms: Gastric cancer antigen Ga55, KIAA1103, Taxin-1, Transforming acidic coiled-coil-containing protein 1
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Disease relevance of TACC1


High impact information on TACC1

  • The full-length TACC proteins form similar polymers when overexpressed, but their interaction with microtubules and tubulin is regulated during the cell cycle [4].
  • Transforming acidic coiled coil 1 (TACC1) is a putative oncogene located within a breast cancer amplicon found on human chromosome 8p11 [5].
  • Although TACC1 has been reported to transform fibroblasts, it is also down-regulated in a subset of mammary tumors treated with anthracyclin [5].
  • Thus, TACC1 positively regulates the Ras and PI3K pathways, promotes Ras-mediated transformation, and prevents apoptosis induced by PI3K pathway inhibition [5].
  • TACC1 also cooperates with tumorigenic mutations in the PI3K pathway and thereby plays an oncogenic role in tumor formation in the murine mammary gland [5].

Chemical compound and disease context of TACC1


Biological context of TACC1

  • We show that TACC1 mRNA gene expression is down-regulated in various types of tumors [1].
  • Using siRNAs, we further show that depletion of chTOG and, to a lesser extent of TACC1, perturbates cell division [7].
  • The TACC1 gene is located in region p12 of chromosome 8; its mRNA is ubiquitously expressed and encodes a protein with an apparent molecular mass of 125 kDa, which is cytoplasmic and mainly perinuclear [1].
  • We speculate that down-regulation of TACC1 may alter the control of mRNA homeostasis in polarized cells and participates in the oncogenic processes [1].
  • Using the full-length TACC1 protein as bait to screen a human mammary epithelial cDNA library, we have identified two genes that are also amplified and overexpressed in tumours derived from different cellular origins [8].

Anatomical context of TACC1


Associations of TACC1 with chemical compounds


Physical interactions of TACC1


Regulatory relationships of TACC1


Other interactions of TACC1

  • AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains [17].
  • Database searches employing the human TACC1 sequence revealed other novel genes, TACC2 and TACC3, with substantial sequence homology particularly in the C-terminal regions encoding the coiled coil domains [17].
  • Using AKAP350A as bait in a yeast two-hybrid screen of a rabbit parietal cell library, we have identified a novel AKAP350-interacting protein, transforming acidic coiled-coil-containing protein 4 (TACC4) [9].
  • We further show that Aurora B knocked down by RNA-mediated interference prevents the formation of the midbody - and consequently affects TACC1 localization at this site - and leads to abnormal cell division and multinucleated cells [18].
  • However, during evolution, the TACC proteins have now acquired the ability to directly interact with components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, and transcription factors) [19].

Analytical, diagnostic and therapeutic context of TACC1


  1. Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators. Conte, N., Charafe-Jauffret, E., Delaval, B., Adélaïde, J., Ginestier, C., Geneix, J., Isnardon, D., Jacquemier, J., Birnbaum, D. Oncogene (2002) [Pubmed]
  2. Serological identification and expression analysis of gastric cancer-associated genes. Linē, A., Stengrēvics, A., Slucka, Z., Li, G., Jankevics, E., Rees, R.C. Br. J. Cancer (2002) [Pubmed]
  3. Aberrations of TACC1 and TACC3 are associated with ovarian cancer. Lauffart, B., Vaughan, M.M., Eddy, R., Chervinsky, D., DiCioccio, R.A., Black, J.D., Still, I.H. BMC women's health [electronic resource]. (2005) [Pubmed]
  4. The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Gergely, F., Karlsson, C., Still, I., Cowell, J., Kilmartin, J., Raff, J.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. Cully, M., Shiu, J., Piekorz, R.P., Muller, W.J., Done, S.J., Mak, T.W. Cancer Res. (2005) [Pubmed]
  6. Cardiac complications after bone marrow transplantation. A report on a series of 63 consecutive transplantations. Cazin, B., Gorin, N.C., Laporte, J.P., Gallet, B., Douay, L., Lopez, M., Najman, A., Duhamel, G. Cancer (1986) [Pubmed]
  7. TACC1-chTOG-Aurora A protein complex in breast cancer. Conte, N., Delaval, B., Ginestier, C., Ferrand, A., Isnardon, D., Larroque, C., Prigent, C., Séraphin, B., Jacquemier, J., Birnbaum, D. Oncogene (2003) [Pubmed]
  8. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells. Lauffart, B., Howell, S.J., Tasch, J.E., Cowell, J.K., Still, I.H. Biochem. J. (2002) [Pubmed]
  9. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. Steadman, B.T., Schmidt, P.H., Shanks, R.A., Lapierre, L.A., Goldenring, J.R. J. Biol. Chem. (2002) [Pubmed]
  10. Altered splicing pattern of TACC1 mRNA in gastric cancer. Line, A., Slucka, Z., Stengrevics, A., Li, G., Rees, R.C. Cancer Genet. Cytogenet. (2002) [Pubmed]
  11. Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells. Pu, J.J., Li, C., Rodriguez, M., Banerjee, D. Cytokine (2001) [Pubmed]
  12. FGFR1 and WT1 are markers of human prostate cancer progression. Devilard, E., Bladou, F., Ramuz, O., Karsenty, G., Dal??s, J.P., Gravis, G., Nguyen, C., Bertucci, F., Xerri, L., Birnbaum, D. BMC Cancer (2006) [Pubmed]
  13. Ionizing radiation at low doses induces inflammatory reactions in human blood. Vicker, M.G., Bultmann, H., Glade, U., Häfker, T. Radiat. Res. (1991) [Pubmed]
  14. Massive BACT chemotherapy with autologous bone marrow transplantation in 17 cases of non-Hodgkin's malignant lymphoma with a very bad prognosis. Philip, T., Biron, P., Hervé, P., Dutou, L., Ehrsam, A., Philip, I., Souillet, G., Plouvier, E., Le Mevel, A., Philippe, N. European journal of cancer & clinical oncology. (1983) [Pubmed]
  15. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Gangisetty, O., Lauffart, B., Sondarva, G.V., Chelsea, D.M., Still, I.H. Oncogene (2004) [Pubmed]
  16. Centrosome maturation: Aurora lights the way to the poles. Brittle, A.L., Ohkura, H. Curr. Biol. (2005) [Pubmed]
  17. AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains. Lappin, T.R., Mullan, R.N., Stewart, J.P., Morgan, N.A., Thompson, A., Maxwell, A.P. Leuk. Lymphoma (2002) [Pubmed]
  18. Aurora B -TACC1 protein complex in cytokinesis. Delaval, B., Ferrand, A., Conte, N., Larroque, C., Hernandez-Verdun, D., Prigent, C., Birnbaum, D. Oncogene (2004) [Pubmed]
  19. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still, I.H., Vettaikkorumakankauv, A.K., DiMatteo, A., Liang, P. BMC Evol. Biol. (2004) [Pubmed]
  20. TACC3 expression is tightly regulated during early differentiation. Sadek, C.M., Pelto-Huikko, M., Tujague, M., Steffensen, K.R., Wennerholm, M., Gustafsson, J.A. Gene Expr. Patterns (2003) [Pubmed]
  21. Effects of intake of a mixture of thiamin, arginine, caffeine, and citric acid on adiposity in healthy subjects with high percent body fat. Muroyama, K., Murosaki, S., Yamamoto, Y., Ishijima, A., Toh, Y. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
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