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Gene Review

WWP1  -  WW domain containing E3 ubiquitin protein...

Homo sapiens

Synonyms: AIP5, Atrophin-1-interacting protein 5, DKFZP434D2111, NEDD4-like E3 ubiquitin-protein ligase WWP1, TGIF-interacting ubiquitin ligase 1, ...
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Disease relevance of WWP1


High impact information on WWP1


Biological context of WWP1


Anatomical context of WWP1

  • Finally, WWP1 was amplified and overexpressed in some cancer cell lines from the prostate and breast, which negatively regulated the function of KLF5 in gene regulation [5].
  • Coexpression of human Notch1 (hN1) depleted WWP1 from the nucleus to colocalise with hN1 in early endosomes, dependent on the presence of the C-terminal HECT domain [9].
  • As expected, WWP1 was expressed, like ENaC, in the bronchiolar epithelium [10].

Physical interactions of WWP1

  • Furthermore we found that full-length expressed WWP1 could interact in vitro with the cytoplasmic domain of human Notch1 [9].
  • Here, we demonstrate that WWP1 interacts with KLF2 in vivo and mediates both poly-ubiquitination and proteasomal degradation of KLF2 [11].

Enzymatic interactions of WWP1

  • However, unlike Smurfs, WWP1 failed to ubiquitinate R-Smads and SnoN [12].

Regulatory relationships of WWP1

  • Using a TGF-beta-responsive reporter in mammalian cells, we found that WWP1 inhibited transcriptional activities induced by TGF-beta [12].
  • Our experiments demonstrate for the first time that WWP1 promotes ubiquitination and degradation of KLF2 and is not involved in the ubiquitin-transfer reaction [11].

Other interactions of WWP1


Analytical, diagnostic and therapeutic context of WWP1


  1. HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway. Martin-Serrano, J., Eastman, S.W., Chung, W., Bieniasz, P.D. J. Cell Biol. (2005) [Pubmed]
  2. Late assembly motifs of human T-cell leukemia virus type 1 and their relative roles in particle release. Heidecker, G., Lloyd, P.A., Fox, K., Nagashima, K., Derse, D. J. Virol. (2004) [Pubmed]
  3. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Bednarek, A.K., Laflin, K.J., Daniel, R.L., Liao, Q., Hawkins, K.A., Aldaz, C.M. Cancer Res. (2000) [Pubmed]
  4. Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Chen, C., Sun, X., Guo, P., Dong, X.Y., Sethi, P., Zhou, W., Zhou, Z., Petros, J., Frierson, H.F., Vessella, R.L., Atfi, A., Dong, J.T. Oncogene (2007) [Pubmed]
  5. Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. Chen, C., Sun, X., Guo, P., Dong, X.Y., Sethi, P., Cheng, X., Zhou, J., Ling, J., Simons, J.W., Lingrel, J.B., Dong, J.T. J. Biol. Chem. (2005) [Pubmed]
  6. A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Huang, K., Johnson, K.D., Petcherski, A.G., Vandergon, T., Mosser, E.A., Copeland, N.G., Jenkins, N.A., Kimble, J., Bresnick, E.H. Gene (2000) [Pubmed]
  7. Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. Flasza, M., Gorman, P., Roylance, R., Canfield, A.E., Baron, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  8. PKA-mediated protein phosphorylation regulates ezrin-WWOX interaction. Jin, C., Ge, L., Ding, X., Chen, Y., Zhu, H., Ward, T., Wu, F., Cao, X., Wang, Q., Yao, X. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch. Flasza, M., Nguyen Huu, N.S., Mazaleyrat, S., Clémence, S., Villemant, C., Clarke, R., Baron, M. Mol. Membr. Biol. (2006) [Pubmed]
  10. Differential expression and localisation of WWP1, a Nedd4-like protein, in epithelia. Malbert-Colas, L., Fay, M., Cluzeaud, F., Blot-Chabaud, M., Farman, N., Dhermy, D., Lecomte, M.C. Pflugers Arch. (2003) [Pubmed]
  11. WWP1-dependent ubiquitination and degradation of the lung Krüppel-like factor, KLF2. Zhang, X., Srinivasan, S.V., Lingrel, J.B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Komuro, A., Imamura, T., Saitoh, M., Yoshida, Y., Yamori, T., Miyazono, K., Miyazawa, K. Oncogene (2004) [Pubmed]
  13. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. Galinier, R., Gout, E., Lortat-Jacob, H., Wood, J., Chroboczek, J. Biochemistry (2002) [Pubmed]
  14. Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. Conkright, M.D., Wani, M.A., Lingrel, J.B. J. Biol. Chem. (2001) [Pubmed]
  15. PCIF1, a novel human WW domain-containing protein, interacts with the phosphorylated RNA polymerase II. Fan, H., Sakuraba, K., Komuro, A., Kato, S., Harada, F., Hirose, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  16. Characterization of KIBRA, a novel WW domain-containing protein. Kremerskothen, J., Plaas, C., Büther, K., Finger, I., Veltel, S., Matanis, T., Liedtke, T., Barnekow, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  17. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Verdecia, M.A., Joazeiro, C.A., Wells, N.J., Ferrer, J.L., Bowman, M.E., Hunter, T., Noel, J.P. Mol. Cell (2003) [Pubmed]
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