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Gene Review

Spred2  -  sprouty-related, EVH1 domain containing 2

Mus musculus

Synonyms: C79158, Spred-2, Sprouty-related, EVH1 domain-containing protein 2
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Disease relevance of Spred2


High impact information on Spred2


Biological context of Spred2

  • Similarly, deletion of the C-terminal Sprouty domain of Spred-1 does not affect cell-cycle progression of G(0)-synchronized cells through to S-phase following growth factor stimulation, while the Sprouty domain is required for Spred-2 function [4].
  • Here, we show a detailed in situ analysis of a mouse strain with a trapped Spred-2 gene, bringing a beta-galactosidase and neomycin fusion gene (beta-geo) under the control of the endogenous Spred-2 promoter [5].

Anatomical context of Spred2

  • In humans, Spred-2 was found to be strongly expressed in glandular epithelia and, at the subcellular level, its immunoreactivity was associated with secretory vesicles [6].

Associations of Spred2 with chemical compounds

  • Both Spred-1 and Spred-2 are membrane-associated substrates of receptor tyrosine kinases and they act as negative regulators of the Ras pathway upon growth factor stimulation [6].


  1. Gene disruption of Spred-2 causes dwarfism. Bundschu, K., Knobeloch, K.P., Ullrich, M., Schinke, T., Amling, M., Engelhardt, C.M., Renné, T., Walter, U., Schuh, K. J. Biol. Chem. (2005) [Pubmed]
  2. Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. Nobuhisa, I., Kato, R., Inoue, H., Takizawa, M., Okita, K., Yoshimura, A., Taga, T. J. Exp. Med. (2004) [Pubmed]
  3. The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Miyoshi, K., Wakioka, T., Nishinakamura, H., Kamio, M., Yang, L., Inoue, M., Hasegawa, M., Yonemitsu, Y., Komiya, S., Yoshimura, A. Oncogene (2004) [Pubmed]
  4. Distinct requirements for the Sprouty domain for functional activity of Spred proteins. King, J.A., Straffon, A.F., D'Abaco, G.M., Poon, C.L., I, S.T., Smith, C.M., Buchert, M., Corcoran, N.M., Hall, N.E., Callus, B.A., Sarcevic, B., Martin, D., Lock, P., Hovens, C.M. Biochem. J. (2005) [Pubmed]
  5. Tissue-specific Spred-2 promoter activity characterized by a gene trap approach. Bundschu, K., Gattenlöhner, S., Knobeloch, K.P., Walter, U., Schuh, K. Gene Expr. Patterns (2006) [Pubmed]
  6. Expression and subcellular localization of Spred proteins in mouse and human tissues. Engelhardt, C.M., Bundschu, K., Messerschmitt, M., Renné, T., Walter, U., Reinhard, M., Schuh, K. Histochem. Cell Biol. (2004) [Pubmed]
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