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Gene Review

Spred1  -  sprouty protein with EVH-1 domain 1,...

Mus musculus

Synonyms: 5730461F13Rik, AL024345, AW047647, Spred-1, Sprouty-related, EVH1 domain-containing protein 1
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Disease relevance of Spred1


High impact information on Spred1


Biological context of Spred1


Anatomical context of Spred1


Associations of Spred1 with chemical compounds

  • Both Spred-1 and Spred-2 are membrane-associated substrates of receptor tyrosine kinases and they act as negative regulators of the Ras pathway upon growth factor stimulation [6].

Other interactions of Spred1

  • To clarify the biological effect of Cav-1/Spred-1 interaction, we used hematopoietic cells that lacked expression of caveolins but expressed Spred-1 [4].


  1. The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Miyoshi, K., Wakioka, T., Nishinakamura, H., Kamio, M., Yang, L., Inoue, M., Hasegawa, M., Yonemitsu, Y., Komiya, S., Yoshimura, A. Oncogene (2004) [Pubmed]
  2. Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. Inoue, H., Kato, R., Fukuyama, S., Nonami, A., Taniguchi, K., Matsumoto, K., Nakano, T., Tsuda, M., Matsumura, M., Kubo, M., Ishikawa, F., Moon, B.G., Takatsu, K., Nakanishi, Y., Yoshimura, A. J. Exp. Med. (2005) [Pubmed]
  3. Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. Nonami, A., Kato, R., Taniguchi, K., Yoshiga, D., Taketomi, T., Fukuyama, S., Harada, M., Sasaki, A., Yoshimura, A. J. Biol. Chem. (2004) [Pubmed]
  4. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. Nonami, A., Taketomi, T., Kimura, A., Saeki, K., Takaki, H., Sanada, T., Taniguchi, K., Harada, M., Kato, R., Yoshimura, A. Genes Cells (2005) [Pubmed]
  5. Tissue engineering: in vitro embryonal nidation in a murine endometrial construct. Stevenson, A.F. Indian J. Exp. Biol. (2003) [Pubmed]
  6. Expression and subcellular localization of Spred proteins in mouse and human tissues. Engelhardt, C.M., Bundschu, K., Messerschmitt, M., Renné, T., Walter, U., Reinhard, M., Schuh, K. Histochem. Cell Biol. (2004) [Pubmed]
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