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Gene Review

Ccr3  -  chemokine (C-C motif) receptor 3

Rattus norvegicus

Synonyms: C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CCR3, ...
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Disease relevance of Ccr3

  • Eotaxin and eotaxin receptor (CCR3) expression in Sephadex particle-induced rat lung inflammation [1].
  • In conclusion, inhibition of the expression of CCR3 decreased pulmonary eosinophilia and reduced AHR after antigen challenge in rats [2].

High impact information on Ccr3

  • CCR3, another RANTES/CCL5 receptor, was constitutively high on macrophages in vivo and in vitro, with down-regulation during AIA [3].
  • This effect was dose-dependently inhibited by compound X, a selective CCR3 antagonist, indicating that, as in eosinophils, the effect was mediated by CCR3 [4].
  • The pattern of eotaxin pulmonary expression and the location of CCR3 receptor positive cells suggest a chemoattractant gradient resulting in migration firstly into the tissue and subsequently through the airway epithelium into the airways [1].
  • RESULTS: Interleukin-1beta down-regulates constitutively expressed surface CCR3 and CCR5 levels implying receptor internalization for re-utilization or destruction, secretion or both [5].

Chemical compound and disease context of Ccr3


Biological context of Ccr3


Analytical, diagnostic and therapeutic context of Ccr3


  1. Eotaxin and eotaxin receptor (CCR3) expression in Sephadex particle-induced rat lung inflammation. Harrington, P.M., Newton, D.J., Williams, C.M., Hunt, J.A., Dearman, R.J., Kimber, I., Coleman, J.W., Flanagan, B.F. International journal of experimental pathology. (1999) [Pubmed]
  2. Effects of Antisense Oligodeoxynucleotides Targeting CCR3 on the Airway Response to Antigen in Rats. Fortin, M., Ferrari, N., Higgins, M.E., Séguin, S., Allam, M., Allakhverdi, Z., Piaget-Rodriguez, C., Paquet, L., Renzi, P.M. Oligonucleotides. (2006) [Pubmed]
  3. Chemokine receptor expression in rat adjuvant-induced arthritis. Haas, C.S., Martinez, R.J., Attia, N., Haines, G.K., Campbell, P.L., Koch, A.E. Arthritis Rheum. (2005) [Pubmed]
  4. Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Woo, C.H., Jeong, D.T., Yoon, S.B., Kim, K.S., Chung, I.Y., Saeki, T., Kim, J.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors. Vassiliadis, S., Balabanidou, V., Papadopoulos, G.K., Athanassakis, I. JOP (2002) [Pubmed]
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