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MeSH Review

Rats, Inbred BN

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Disease relevance of Rats, Inbred BN


High impact information on Rats, Inbred BN

  • In contrast, BN rats pretreated with HgCl2-resistant allogeneic Lewis bone marrow and transient FK506 showed less clinical disease and were completely protected from mortality [6].
  • Unfractionated BN rat splenocytes and purified T cells exposed to HgCl2 expressed high levels of IL-4 mRNA [7].
  • For suppression of primary tumor growth and metastatic spread, aspirin and theophylline, either alone or combined, were given daily to inbred female BN rats after sc implantation of a syngeneic nonimmunogenic tumor [8].
  • The same DES treatment produced no significant growth (8.9 +/- 0.5 mg for treated females versus 8.7 +/- 1.1 for untreated females) or morphological changes in Brown Norway (BN) rat pituitaries [9].
  • Preliminary experiments showed that different angiotensin-converting enzyme (ACE) inhibitors protect against rupture of the IEL in the BN rat to a greater extent than hydralazine, suggesting a role of the renin-angiotensin system (RAS) in this phenomenon [10].

Chemical compound and disease context of Rats, Inbred BN


Biological context of Rats, Inbred BN


Anatomical context of Rats, Inbred BN


Associations of Rats, Inbred BN with chemical compounds

  • To explore this possibility, we have treated male BN rats from 4.5 to 14 weeks of age with either enalapril or losartan (both at 1, 3, and 10 mg x kg(-1) x d(-1)) or with the calcium antagonists mibefradil (at 3, 10, 30, and 45 mg x kg(-1) x d(-1)) and amlodipine (at 30 mg x kg(-1) x d(-1)) [10].
  • The present study demonstrates that mercuric chloride (HgCl2) induces a striking increase of total serum IgE in Brown Norway (BN) rats [25].
  • The hyperoxia-treated BN rats showed a significant reduction in retinal PEDF, but they showed a substantial increase of VEGF at both the protein and RNA levels, resulting in an increased VEGF-to-PEDF ratio [5].
  • In streptozotocin (STZ)-induced diabetes, Brown Norway (BN) rats developed sustained vascular hyperpermeability in the retina during the entire experimental period (16 weeks of diabetes), while diabetic Sprague Dawley (SD) rats only showed retinal hyperpermeability from 3 to 10 days after the onset of diabetes [26].
  • If carbonyl iron is used as adjuvant in vivo there is no increase in NO levels in the BN rat and they are rendered highly susceptible to EAE [27].

Gene context of Rats, Inbred BN

  • Results from BN rats congenic for the Lewis Aiid3 locus, which we mapped to a 1.2-cM interval, showed a stronger effect of this region [28].
  • In situ hybridization showed that cells expressing IL-4 and -5 mRNA were increased in the airways of the lungs of BN rats after OA challenge (P < 0.05) and that cells expressing mRNA for IFN-gamma and IL-2 were higher in SD than in BN rats after antigen challenge (P < 0.05) [29].
  • These results demonstrate that OXP induces a shift towards a Th2 response, inhibits TNF-alpha mRNA transcription locally in joint and systemically in spleen, and has a protective effect against arthritis similar to that produced by sTNFR in the HgCl2-treated BN rat [30].
  • Similarly, Scd1 mRNA expression was approximately 4-fold higher in the normal liver of F344 rats, which are susceptible to hepatocarcinogenesis, than in Brown Norway (BN) rats, which are resistant [31].
  • RTPCR using naive conjunctivas detected more IL-4, IFN-gamma, and IFN-gamma R beta-chain RNA expression in BN rats [32].

Analytical, diagnostic and therapeutic context of Rats, Inbred BN


  1. Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. Pravenec, M., Zidek, V., Simakova, M., Kren, V., Krenova, D., Horky, K., Jachymova, M., Mikova, B., Kazdova, L., Aitman, T.J., Churchill, P.C., Webb, R.C., Hingarh, N.H., Yang, Y., Wang, J.M., Lezin, E.M., Kurtz, T.W. J. Clin. Invest. (1999) [Pubmed]
  2. Effect of the interval between high dose 1-beta-D-arabinofuranosylcytosine injections on leukemic cell load, intestinal toxicity, and normal hematopoietic stem cells in a rat model for acute myelogenous leukemia. Colly, L.P., Peters, W.G., Willemze, R. Cancer Res. (1986) [Pubmed]
  3. Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders. Savignac, M., Gomes, B., Gallard, A., Narbonnet, S., Moreau, M., Leclerc, C., Paulet, P., Mariamé, B., Druet, P., Saoudi, A., Fournié, G.J., Guéry, J.C., Pelletier, L. J. Immunol. (2004) [Pubmed]
  4. p30-Anti-p30 immune complexes: intravascular clearance and extravascular sequestration in rats bearing Moloney sarcoma. Jennette, J.C., Feldman, J.D. J. Immunol. (1978) [Pubmed]
  5. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Gao, G., Li, Y., Fant, J., Crosson, C.E., Becerra, S.P., Ma, J.X. Diabetes (2002) [Pubmed]
  6. Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. A relationship between allo- and autoimmunity. Delaney, C.P., Murase, N., Chen-Woan, M., Fung, J.J., Starzl, T.E., Demetris, A.J. J. Clin. Invest. (1996) [Pubmed]
  7. Mercuric chloride, a chemical responsible for T helper cell (Th)2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4. Prigent, P., Saoudi, A., Pannetier, C., Graber, P., Bonnefoy, J.Y., Druet, P., Hirsch, F. J. Clin. Invest. (1995) [Pubmed]
  8. Reductive effect of aspirin treatment on primary tumor growth and metastasis of implanted fibrosarcoma in rats. Kort, W.J., Hulsman, L.O., van Schalkwijk, W.P., Weijma, I.M., Zondervan, P.E., Westbroek, D.L. J. Natl. Cancer Inst. (1986) [Pubmed]
  9. Genetic separation of tumor growth and hemorrhagic phenotypes in an estrogen-induced tumor. Wendell, D.L., Herman, A., Gorski, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Huang, W., Alhenc Gelas, F., Osborne-Pellegrin, M.J. Circ. Res. (1998) [Pubmed]
  11. Alterations in intracellular reactive oxygen species generation and redox potential modulate mast cell function. Wolfreys, K., Oliveira, D.B. Eur. J. Immunol. (1997) [Pubmed]
  12. Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats: a case of gene-environment interaction. Pausová, Z., Paus, T., Sedová, L., Bérubé, J. Kidney Int. (2003) [Pubmed]
  13. IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription. Wu, Z., Turner, D.R., Oliveira, D.B. Int. Immunol. (2001) [Pubmed]
  14. Antioxidants inhibit mercuric chloride-induced early vasculitis. Wu, Z., Turner, D.R., Oliveira, D.B. Int. Immunol. (2002) [Pubmed]
  15. Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats. Drenjancevic-Peric, I., Phillips, S.A., Falck, J.R., Lombard, J.H. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  16. Cosegregation of blood pressure with a kallikrein gene family polymorphism. Pravenec, M., Kren, V., Kunes, J., Scicli, A.G., Carretero, O.A., Simonet, L., Kurtz, T.W. Hypertension (1991) [Pubmed]
  17. Interleukin-2-induced increased airway responsiveness and lung Th2 cytokine expression occur after antigen challenge through the leukotriene pathway. Nag, S., Lamkhioued, B., Renzi, P.M. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  18. Immunoregulation of mercuric chloride-induced autoimmunity in Brown Norway rats: a role for CD8+ T cells revealed by in vivo depletion studies. Mathieson, P.W., Stapleton, K.J., Oliveira, D.B., Lockwood, C.M. Eur. J. Immunol. (1991) [Pubmed]
  19. Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: support for a role for Th2 cell activity. Qasim, F.J., Thiru, S., Gillespie, K. Clin. Exp. Immunol. (1997) [Pubmed]
  20. Kinetics of the in vitro lymphocyte response to myelin basic protein in the the Lewis and Brown Norway strains of rat. Sheffield, W.D., Gonatas, N.K., Kim, S.U. J. Immunol. (1977) [Pubmed]
  21. Autoimmunity induced by HgCl2 in Brown-Norway rats. II. Monoclonal antibodies sharing specificities and idiotypes with mouse natural monoclonal antibodies. Lymberi, P., Hirsch, F., Kuhn, J., Ternynck, T., Druet, P., Avrameas, S. J. Immunol. (1986) [Pubmed]
  22. Transfer of tubulointerstitial nephritis in the Brown Norway rat with anti-tubular basement membrane antibody: quantitation and kinetics of binding and effect of decomplementation. Bannister, K.M., Wilson, C.B. J. Immunol. (1985) [Pubmed]
  23. Increased tumor necrosis factor-alpha (TNF-alpha) gene expression in parainfluenza type 1 (Sendai) virus-induced bronchiolar fibrosis. Uhl, E.W., Moldawer, L.L., Busse, W.W., Jack, T.J., Castleman, W.L. Am. J. Pathol. (1998) [Pubmed]
  24. Influence of elastin gene polymorphism on the elastin content of the aorta: A study in 2 strains of rat. Sauvage, M., Osborne-Pellegrin, M., Deslandes-Le Flohic, F., Jacob, M.P. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  25. Induction of IgE synthesis and potentiation of anti-ovalbumin IgE antibody response by HgCl2 in the rat. Prouvost-Danon, A., Abadie, A., Sapin, C., Bazin, H., Druet, P. J. Immunol. (1981) [Pubmed]
  26. Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathy. Zhang, S.X., Ma, J.X., Sima, J., Chen, Y., Hu, M.S., Ottlecz, A., Lambrou, G.N. Am. J. Pathol. (2005) [Pubmed]
  27. Nitric oxide contributes to resistance of the Brown Norway rat to experimental autoimmune encephalomyelitis. Staykova, M.A., Paridaen, J.T., Cowden, W.B., Willenborg, D.O. Am. J. Pathol. (2005) [Pubmed]
  28. Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10. Mas, M., Cavaillès, P., Colacios, C., Subra, J.F., Lagrange, D., Calise, M., Christen, M.O., Druet, P., Pelletier, L., Gauguier, D., Fournié, G.J. J. Immunol. (2004) [Pubmed]
  29. Cytokine expression in the presence or absence of late airway responses after antigen challenge of sensitized rats. Renzi, P.M., al Assaad, A.S., Yang, J., Yasruel, Z., Hamid, Q. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  30. Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Kiely, P.D., Gillespie, K.M., Oliveira, D.B. Eur. J. Immunol. (1995) [Pubmed]
  31. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Falvella, F.S., Pascale, R.M., Gariboldi, M., Manenti, G., De Miglio, M.R., Simile, M.M., Dragani, T.A., Feo, F. Carcinogenesis (2002) [Pubmed]
  32. Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats. Fukushima, A., Ozaki, A., Fukata, K., Ueno, H. Microbiol. Immunol. (2003) [Pubmed]
  33. In vitro colony formation of transplantable rat leukemias in comparison with human acute myeloid leukemia. van Bekkum, D.W., van Oosterom, P., Dicke, K.A. Cancer Res. (1976) [Pubmed]
  34. Polyclonal effect of HgCl2 in the rat, its possible role in an experimental autoimmune disease. Hirsch, F., Couderc, J., Sapin, C., Fournie, G., Druet, P. Eur. J. Immunol. (1982) [Pubmed]
  35. The role of antibody in rat renal allograft rejection. I. Absence of antibody to erythrocyte-associated antigens is associated with enhanced renal allograft survival. Majoor, G.D., van de Gaar, M.J., Vlek, L.F., van Breda Vriesman, P.J. Transplantation (1981) [Pubmed]
  36. Reduced interferon-gamma secretion by natural killer cells from rats susceptible to postviral chronic airway dysfunction. Mikus, L.D., Rosenthal, L.A., Sorkness, R.L., Lemanske, R.F. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
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