Gene Review:
Ccr3 - chemokine (C-C motif) receptor 3
Mus musculus
Synonyms:
C-C CKR-3, CC-CKR-3, CC-CKR3, CCR-3, CCR3, ...
- CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma. Shen, H.H., Xu, F., Zhang, G.S., Wang, S.B., Xu, W.H. Acta Pharmacol. Sin. (2006)
- The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. Pope, S.M., Zimmermann, N., Stringer, K.F., Karow, M.L., Rothenberg, M.E. J. Immunol. (2005)
- Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. John, A.E., Thomas, M.S., Berlin, A.A., Lukacs, N.W. Am. J. Pathol. (2005)
- Expression and participation of eotaxin during mycobacterial (type 1) and schistosomal (type 2) antigen-elicited granuloma formation. Ruth, J.H., Lukacs, N.W., Warmington, K.S., Polak, T.J., Burdick, M., Kunkel, S.L., Strieter, R.M., Chensue, S.W. J. Immunol. (1998)
- Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries. Houimel, M., Loetscher, P., Baggiolini, M., Mazzucchelli, L. Eur. J. Immunol. (2001)
- CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. Ma, W., Bryce, P.J., Humbles, A.A., Laouini, D., Yalcindag, A., Alenius, H., Friend, D.S., Oettgen, H.C., Gerard, C., Geha, R.S. J. Clin. Invest. (2002)
- Lymph node trafficking and antigen presentation by endobronchial eosinophils. Shi, H.Z., Humbles, A., Gerard, C., Jin, Z., Weller, P.F. J. Clin. Invest. (2000)
- Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux, F., Gharaee-Kermani, M., Liu, T., Morel, V., McGarry, B., Ullenbruch, M., Kunkel, S.L., Wang, J., Xing, Z., Phan, S.H. Am. J. Pathol. (2005)
- The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. Chen, Z., Yu, S., Bakhiet, M., Winblad, B., Zhu, J. J. Neurochem. (2003)
- Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines. Duchesnes, C.E., Murphy, P.M., Williams, T.J., Pease, J.E. Mol. Immunol. (2006)
- The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation. Pease, J.E., Wang, J., Ponath, P.D., Murphy, P.M. J. Biol. Chem. (1998)
- LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin. Penido, C., Castro-Faria-Neto, H.C., Vieira-de-Abreu, A., Figueiredo, R.T., Pelled, A., Martins, M.A., Jose, P.J., Williams, T.J., Bozza, P.T. Am. J. Respir. Cell Mol. Biol. (2001)
- Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse. Quackenbush, E.J., Aguirre, V., Wershil, B.K., Gutierrez-Ramos, J.C. J. Leukoc. Biol. (1997)
- The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Humbles, A.A., Lu, B., Friend, D.S., Okinaga, S., Lora, J., Al-Garawi, A., Martin, T.R., Gerard, N.P., Gerard, C. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Regulation of chemokine receptor expression in eosinophils. Nagase, H., Miyamasu, M., Yamaguchi, M., Fujisawa, T., Kawasaki, H., Ohta, K., Yamamoto, K., Morita, Y., Hirai, K. Int. Arch. Allergy Immunol. (2001)
- Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies. Zhang, L., Soares, M.P., Guan, Y., Matheravidathu, S., Wnek, R., Johnson, K.E., Meisher, A., Iliff, S.A., Mudgett, J.S., Springer, M.S., Daugherty, B.L. J. Biol. Chem. (2002)
- Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation. Wise, E.L., Duchesnes, C., da Fonseca, P.C., Allen, R.A., Williams, T.J., Pease, J.E. J. Biol. Chem. (2007)
- CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. Fulkerson, P.C., Zhu, H., Williams, D.A., Zimmermann, N., Rothenberg, M.E. Blood (2005)
- The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Dixon, H., Blanchard, C., Deschoolmeester, M.L., Yuill, N.C., Christie, J.W., Rothenberg, M.E., Else, K.J. Eur. J. Immunol. (2006)
- Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Cook, W.J., Kramer, M.F., Walker, R.M., Burwell, T.J., Holman, H.A., Coen, D.M., Knipe, D.M. Virol. J. (2004)
- Association of CD45(dim)VLA-4 (+) cells with the NKT cell lineage and their selective expression of IL-13, IP-15, and CCR3 transcripts. Matejuk, A., Afentoulis, M. Arch. Immunol. Ther. Exp. (Warsz.) (2006)
- CCR3-blocking antibody inhibits allergen-induced eosinophil recruitment in human skin xenografts from allergic patients. Sénéchal, S., Fahy, O., Gentina, T., Vorng, H., Capron, M., Walls, A.F., McEuen, A.R., Buckley, M.G., Hamid, Q., Wallaert, B., Tonnel, A.B., Tsicopoulos, A. Lab. Invest. (2002)
- The CCR3 receptor is involved in eosinophil differentiation and is up-regulated by Th2 cytokines in CD34+ progenitor cells. Lamkhioued, B., Abdelilah, S.G., Hamid, Q., Mansour, N., Delespesse, G., Renzi, P.M. J. Immunol. (2003)
- Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils. Gerber, B.O., Zanni, M.P., Uguccioni, M., Loetscher, M., Mackay, C.R., Pichler, W.J., Yawalkar, N., Baggiolini, M., Moser, B. Curr. Biol. (1997)
- Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. De Lucca, G.V., Kim, U.T., Vargo, B.J., Duncia, J.V., Santella, J.B., Gardner, D.S., Zheng, C., Liauw, A., Wang, Z., Emmett, G., Wacker, D.A., Welch, P.K., Covington, M., Stowell, N.C., Wadman, E.A., Das, A.M., Davies, P., Yeleswaram, S., Graden, D.M., Solomon, K.A., Newton, R.C., Trainor, G.L., Decicco, C.P., Ko, S.S. J. Med. Chem. (2005)