Gene Review:
CCR3 - chemokine (C-C motif) receptor 3
Homo sapiens
Synonyms:
C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CD193, ...
Sallusto,
Lenig,
Mackay,
Lanzavecchia,
Sehmi,
Dorman,
Baatjes,
Watson,
Foley,
Ying,
Robinson,
Kay,
O'Byrne,
Denburg,
Culley,
Fadlon,
Kirchem,
Williams,
Jose,
Pease,
Bisset,
Schmid-Grendelmeier,
Loetscher,
Pellegrino,
Gong,
Mattioli,
Loetscher,
Bardi,
Baggiolini,
Clark-Lewis,
Matsumoto,
Hirashima,
Kita,
Gleich,
Heiman,
Abonyo,
Darling-Reed,
Alexander,
- CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. He, J., Chen, Y., Farzan, M., Choe, H., Ohagen, A., Gartner, S., Busciglio, J., Yang, X., Hofmann, W., Newman, W., Mackay, C.R., Sodroski, J., Gabuzda, D. Nature (1997)
- Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma. Kleinhans, M., Tun-Kyi, A., Gilliet, M., Kadin, M.E., Dummer, R., Burg, G., Nestle, F.O. Blood (2003)
- Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. Ying, S., Meng, Q., Zeibecoglou, K., Robinson, D.S., Macfarlane, A., Humbert, M., Kay, A.B. J. Immunol. (1999)
- Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells. Cheng, S.S., Lukacs, N.W., Kunkel, S.L. J. Immunol. (2002)
- Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. Beaulieu, S., Robbiani, D.F., Du, X., Rodrigues, E., Ignatius, R., Wei, Y., Ponath, P., Young, J.W., Pope, M., Steinman, R.M., Mojsov, S. J. Immunol. (2002)
- Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Xia, M.Q., Qin, S.X., Wu, L.J., Mackay, C.R., Hyman, B.T. Am. J. Pathol. (1998)
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J. Cell (1996)
- In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Scarlatti, G., Tresoldi, E., Björndal, A., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyö, E.M., Lusso, P. Nat. Med. (1997)
- Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat. Kudlacz, E.M., Whitney, C.A., Andresen, C.J., Umland, J.P., Cheng, J.B. Br. J. Pharmacol. (1999)
- A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. Sabroe, I., Peck, M.J., Van Keulen, B.J., Jorritsma, A., Simmons, G., Clapham, P.R., Williams, T.J., Pease, J.E. J. Biol. Chem. (2000)
- The role of mitogen-activated protein kinases in eotaxin-induced cytokine production from bronchial epithelial cells. Cui, C.H., Adachi, T., Oyamada, H., Kamada, Y., Kuwasaki, T., Yamada, Y., Saito, N., Kayaba, H., Chihara, J. Am. J. Respir. Cell Mol. Biol. (2002)
- Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Sehmi, R., Dorman, S., Baatjes, A., Watson, R., Foley, R., Ying, S., Robinson, D.S., Kay, A.B., O'Byrne, P.M., Denburg, J.A. Immunology (2003)
- Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., Ponath, P.D., Mackay, C.R. J. Clin. Invest. (1997)
- Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Langenkamp, A., Nagata, K., Murphy, K., Wu, L., Lanzavecchia, A., Sallusto, F. Eur. J. Immunol. (2003)
- Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Culley, F.J., Fadlon, E.J., Kirchem, A., Williams, T.J., Jose, P.J., Pease, J.E. Eur. J. Immunol. (2003)
- Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Coulin, F., Power, C.A., Alouani, S., Peitsch, M.C., Schroeder, J.M., Moshizuki, M., Clark-Lewis, I., Wells, T.N. Eur. J. Biochem. (1997)
- Cytokine-stimulated human lung alveolar epithelial cells release eotaxin-2 (CCL24) and eotaxin-3 (CCL26). Heiman, A.S., Abonyo, B.O., Darling-Reed, S.F., Alexander, M.S. J. Interferon Cytokine Res. (2005)
- HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3. Hadida, F., Vieillard, V., Autran, B., Clark-Lewis, I., Baggiolini, M., Debré, P. J. Exp. Med. (1998)
- High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Uguccioni, M., Mackay, C.R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G.J., Rao, P., Ponath, P.D., Baggiolini, M., Dahinden, C.A. J. Clin. Invest. (1997)
- Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells. Zella, D., Barabitskaja, O., Casareto, L., Romerio, F., Secchiero, P., Reitz, M.S., Gallo, R.C., Weichold, F.F. J. Immunol. (1999)
- Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. Struyf, S., Menten, P., Lenaerts, J.P., Put, W., D'Haese, A., De Clercq, E., Schols, D., Proost, P., Van Damme, J. Eur. J. Immunol. (2001)
- Expression of the chemokine receptor CCR3 on human mast cells. de Paulis, A., Annunziato, F., Di Gioia, L., Romagnani, S., Carfora, M., Beltrame, C., Marone, G., Romagnani, P. Int. Arch. Allergy Immunol. (2001)
- Autocrine regulation of eotaxin in normal human bronchial epithelial cells. Saito, H., Shimizu, H., Akiyama, K. Int. Arch. Allergy Immunol. (2000)
- Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. White, J.R., Imburgia, C., Dul, E., Appelbaum, E., O'Donnell, K., O'Shannessy, D.J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N.A., Kaiser, K., Foley, J.J., Schmidt, D.B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G.F., Schleimer, R.P., Sarau, H.M. J. Leukoc. Biol. (1997)
- Chemokine receptor CCR3 function is highly dependent on local pH and ionic strength. Dairaghi, D.J., Oldham, E.R., Bacon, K.B., Schall, T.J. J. Biol. Chem. (1997)
- Biological activities of ecalectin: a novel eosinophil-activating factor. Matsumoto, R., Hirashima, M., Kita, H., Gleich, G.J. J. Immunol. (2002)
- Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation. Fernandez, E.J., Wilken, J., Thompson, D.A., Peiper, S.C., Lolis, E. Biochemistry (2000)
- NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2. Mayer, K.L., Stone, M.J. Biochemistry (2000)
- The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. Loetscher, P., Pellegrino, A., Gong, J.H., Mattioli, I., Loetscher, M., Bardi, G., Baggiolini, M., Clark-Lewis, I. J. Biol. Chem. (2001)
- Chemokine receptors and virus entry in the central nervous system. Gabuzda, D., Wang, J. J. Neurovirol. (1999)
- Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Bisset, L.R., Schmid-Grendelmeier, P. Current opinion in pulmonary medicine. (2005)
- Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Ying, S., Robinson, D.S., Meng, Q., Rottman, J., Kennedy, R., Ringler, D.J., Mackay, C.R., Daugherty, B.L., Springer, M.S., Durham, S.R., Williams, T.J., Kay, A.B. Eur. J. Immunol. (1997)
- Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. Sallusto, F., Lenig, D., Mackay, C.R., Lanzavecchia, A. J. Exp. Med. (1998)
- HIV-1 Tat protein mimicry of chemokines. Albini, A., Ferrini, S., Benelli, R., Sforzini, S., Giunciuglio, D., Aluigi, M.G., Proudfoot, A.E., Alouani, S., Wells, T.N., Mariani, G., Rabin, R.L., Farber, J.M., Noonan, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Granulocyte-macrophage colony stimulating factor up-regulates CCR1 in human neutrophils. Cheng, S.S., Lai, J.J., Lukacs, N.W., Kunkel, S.L. J. Immunol. (2001)
- Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers. Menzies-Gow, A., Ying, S., Sabroe, I., Stubbs, V.L., Soler, D., Williams, T.J., Kay, A.B. J. Immunol. (2002)
- Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner. Bochner, B.S., Bickel, C.A., Taylor, M.L., MacGlashan, D.W., Gray, P.W., Raport, C.J., Godiska, R. J. Allergy Clin. Immunol. (1999)