Gene Review:
SH2D1B - SH2 domain containing 1B
Homo sapiens
Synonyms:
EAT-2, EAT2, EWS/FLI1-activated transcript 2, SH2 domain-containing protein 1B
- EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene. Thompson, A.D., Braun, B.S., Arvand, A., Stewart, S.D., May, W.A., Chen, E., Korenberg, J., Denny, C. Oncogene (1996)
- Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Morra, M., Lu, J., Poy, F., Martin, M., Sayos, J., Calpe, S., Gullo, C., Howie, D., Rietdijk, S., Thompson, A., Coyle, A.J., Denny, C., Yaffe, M.B., Engel, P., Eck, M.J., Terhorst, C. EMBO J. (2001)
- The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Gu, C., Tangye, S.G., Sun, X., Luo, Y., Lin, Z., Wu, J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- NK cell regulation by SLAM family receptors and SAP-related adapters. Veillette, A. Immunol. Rev. (2006)
- The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. Tassi, I., Colonna, M. J. Immunol. (2005)
- The SAP family of adaptors in immune regulation. Latour, S., Veillette, A. Semin. Immunol. (2004)
- Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family. Fraser, C.C., Howie, D., Morra, M., Qiu, Y., Murphy, C., Shen, Q., Gutierrez-Ramos, J.C., Coyle, A., Kingsbury, G.A., Terhorst, C. Immunogenetics (2002)
- Modulation of 2B4 (CD244) activity and regulated SAP expression in human NK cells. Endt, J., Eissmann, P., Hoffmann, S.C., Meinke, S., Giese, T., Watzl, C. Eur. J. Immunol. (2007)
- CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Tangye, S.G., van de Weerdt, B.C., Avery, D.T., Hodgkin, P.D. Eur. J. Immunol. (2002)
- Differential expression of murine CD81 highlighted by new anti-mouse CD81 monoclonal antibodies. Maecker, H.T., Todd, S.C., Kim, E.C., Levy, S. Hybridoma (2000)
- Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Calpe, S., Erdos, E., Liao, G., Wang, N., Rietdijk, S., Simarro, M., Scholtz, B., Mooney, J., Lee, C.H., Shin, M.S., Rajnavölgyi, E., Schatzle, J., Morse, H.C., Terhorst, C., Lanyi, A. Immunogenetics (2006)
- Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells. Eissmann, P., Watzl, C. J. Immunol. (2006)