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Gene Review

SLAMF1  -  signaling lymphocytic activation molecule...

Homo sapiens

Synonyms: CD150, CDw150, IPO-3, SLAM, Signaling lymphocytic activation molecule
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Disease relevance of SLAMF1


High impact information on SLAMF1

  • Here we show that human SLAM (signalling lymphocyte-activation molecule; also known as CDw150), a recently discovered membrane glycoprotein expressed on some T and B cells, is a cellular receptor for measles virus, including the Edmonston strain [5].
  • The protein SLAM (also known as CDw150), which is present on the surface of B and T cells, forms such a receptor-ligand pair as it is a self-ligand [6].
  • Consistent with its single src homology 2 (SH2) domain architecture and unusually high affinity for SLAM (also called CD150), SAP has been suggested to function by blocking binding of SHP-2 or other SH2-containing signalling proteins to SLAM receptors [7].
  • The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a 'free SH2 domain' that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface proteins [8].
  • Here we show that the signaling pathways triggered during platelet aggregation include an intrinsic pro-thrombotic activity mediated by 2 homophilic adhesion molecules, CD84 and CD150 (SLAM [signaling lymphocyte activation molecule]), which are tyrosine phosphorylated in a platelet aggregation-dependent fashion [9].

Chemical compound and disease context of SLAMF1

  • Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus [10].

Biological context of SLAMF1


Anatomical context of SLAMF1


Associations of SLAMF1 with chemical compounds

  • The EAT-2 structure in complex with a phosphotyrosine peptide containing a sequence motif with Tyr281 of the cytoplasmic tail of CD150 is very similar to the structure of SH2D1A complexed with the same peptide [8].
  • A TxYxxV/I motif in the CD150 cytoplasmic tail can bind different SH2-containing molecules, including tyrosine and inositol phosphatases, Src family kinases, and adaptor molecules [3].
  • A leucine residue, Leu278, further stabilizes nonphospho binding of SAP to Tyr281 of CD150 [2].
  • Human signalling lymphocyte activation molecule (SLAM; also called CD150), a membrane glycoprotein of the immunoglobulin superfamily, acts as a cellular receptor for MV [17].

Regulatory relationships of SLAMF1

  • CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A [14].
  • All CD-VLPs formed syncytia after infection in CHO cells expressing CD150 but not in those expressing CD46 [18].
  • Notably, an alternative MV receptor SLAM CDw150 was neither expressed nor recruited to this complex throughout GM-CSF-mediated Mphi differentiation [19].

Other interactions of SLAMF1

  • Using GST-fusion proteins with single replacements of tyrosine at Y269F, Y281F, Y307F, or Y327F in the CD150 cytoplasmic tail, we found that the same phosphorylated Y281 and Y327 are essential for both SHP-2 and SHIP binding [14].
  • In contrast to CD84, CD150 was absent on resting monocytes and immature dendritic cells (DCs) [15].
  • Strikingly, CDw150 was not detected in monocytes and moderately induced in iDCs, while CD46 was constantly expressed in monocyte-to-iDC differentiation [16].
  • DSHP binds to the cytoplasmic domains of CDw150 (Signaling Lymphocyte Activation Molecule, SLAM) and 2B4, and may regulate signals transmitted by these receptors in T and NK cells, respectively [20].
  • TLR-mediated functional potential of DCs may affect the degree of MV amplification through distinct MV strain-specific receptor usage of CDw150 or CD46 [16].

Analytical, diagnostic and therapeutic context of SLAMF1

  • Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation [2].
  • Ligation of CDw150 induces the rapid dephosphorylation of both SHIP and CDw150 as well as the association of Lyn and Fgr with SHIP [12].
  • To better evaluate the role of hSLAM in MV pathogenesis and MV-induced immunosuppression, we created transgenic (tg) mice that expressed the hSLAM molecule under the control of the lck proximal promoter. hSLAM was expressed on CD4(+) and CD8(+) T cells in the blood and spleen and also on CD4(+), CD8(+), CD4(+) CD8(+), and CD4(-) CD8(-) thymocytes [21].
  • METHODS: The expression of CD150 splicing forms and SH2D1A adaptor protein in HD primary lymphoma tissue and cell lines were analyzed by RT-PCR method [22].


  1. The dual-function CD150 receptor subfamily: the viral attraction. Sidorenko, S.P., Clark, E.A. Nat. Immunol. (2003) [Pubmed]
  2. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Howie, D., Simarro, M., Sayos, J., Guirado, M., Sancho, J., Terhorst, C. Blood (2002) [Pubmed]
  3. The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. Mikhalap, S.V., Shlapatska, L.M., Yurchenko, O.V., Yurchenko, M.Y., Berdova, G.G., Nichols, K.E., Clark, E.A., Sidorenko, S.P. Blood (2004) [Pubmed]
  4. CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Wang, N., Morra, M., Wu, C., Gullo, C., Howie, D., Coyle, T., Engel, P., Terhorst, C. Immunogenetics (2001) [Pubmed]
  5. SLAM (CDw150) is a cellular receptor for measles virus. Tatsuo, H., Ono, N., Tanaka, K., Yanagi, Y. Nature (2000) [Pubmed]
  6. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., van Schaik, S., Notarangelo, L., Geha, R., Roncarolo, M.G., Oettgen, H., De Vries, J.E., Aversa, G., Terhorst, C. Nature (1998) [Pubmed]
  7. SAP couples Fyn to SLAM immune receptors. Chan, B., Lanyi, A., Song, H.K., Griesbach, J., Simarro-Grande, M., Poy, F., Howie, D., Sumegi, J., Terhorst, C., Eck, M.J. Nat. Cell Biol. (2003) [Pubmed]
  8. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Morra, M., Lu, J., Poy, F., Martin, M., Sayos, J., Calpe, S., Gullo, C., Howie, D., Rietdijk, S., Thompson, A., Coyle, A.J., Denny, C., Yaffe, M.B., Engel, P., Eck, M.J., Terhorst, C. EMBO J. (2001) [Pubmed]
  9. Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. Nanda, N., Andre, P., Bao, M., Clauser, K., Deguzman, F., Howie, D., Conley, P.B., Terhorst, C., Phillips, D.R. Blood (2005) [Pubmed]
  10. Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus. Ohno, S., Seki, F., Ono, N., Yanagi, Y. J. Gen. Virol. (2003) [Pubmed]
  11. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. Morra, M., Simarro-Grande, M., Martin, M., Chen, A.S., Lanyi, A., Silander, O., Calpe, S., Davis, J., Pawson, T., Eck, M.J., Sumegi, J., Engel, P., Li, S.C., Terhorst, C. J. Biol. Chem. (2001) [Pubmed]
  12. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. Mikhalap, S.V., Shlapatska, L.M., Berdova, A.G., Law, C.L., Clark, E.A., Sidorenko, S.P. J. Immunol. (1999) [Pubmed]
  13. Mechanism of CD150 (SLAM) down regulation from the host cell surface by measles virus hemagglutinin protein. Welstead, G.G., Hsu, E.C., Iorio, C., Bolotin, S., Richardson, C.D. J. Virol. (2004) [Pubmed]
  14. CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. Shlapatska, L.M., Mikhalap, S.V., Berdova, A.G., Zelensky, O.M., Yun, T.J., Nichols, K.E., Clark, E.A., Sidorenko, S.P. J. Immunol. (2001) [Pubmed]
  15. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Romero, X., Benítez, D., March, S., Vilella, R., Miralpeix, M., Engel, P. Tissue Antigens (2004) [Pubmed]
  16. Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification. Murabayashi, N., Kurita-Taniguchi, M., Ayata, M., Matsumoto, M., Ogura, H., Seya, T. Microbes Infect. (2002) [Pubmed]
  17. Measles virus: cellular receptors, tropism and pathogenesis. Yanagi, Y., Takeda, M., Ohno, S. J. Gen. Virol. (2006) [Pubmed]
  18. Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus. Ishida, H., Ayata, M., Shingai, M., Matsunaga, I., Seto, Y., Katayama, Y., Iritani, N., Seya, T., Yanagi, Y., Matsuoka, O., Yamano, T., Ogura, H. Microbiol. Immunol. (2004) [Pubmed]
  19. Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Kurita-Taniguchi, M., Hazeki, K., Murabayashi, N., Fukui, A., Tsuji, S., Matsumoto, M., Toyoshima, K., Seya, T. Mol. Immunol. (2002) [Pubmed]
  20. X-linked lymphoproliferative disease: genetics and biochemistry. Nichols, K.E. Reviews in immunogenetics. (2000) [Pubmed]
  21. Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule. Hahm, B., Arbour, N., Naniche, D., Homann, D., Manchester, M., Oldstone, M.B. J. Virol. (2003) [Pubmed]
  22. The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma cell lines. Yurchenko, M.Y., Kashuba, E.V., Shlapatska, L.M., Sivkovich, S.A., Sidorenko, S.P. Experimental oncology. (2005) [Pubmed]
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