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Gene Review

PROKR2  -  prokineticin receptor 2

Homo sapiens

Synonyms: G-protein coupled receptor 73-like 1, GPR73L1, GPR73b, GPRg2, HH3, ...
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Disease relevance of PROKR2

  • Stress conditions such as serum withdrawal, TNF-alpha, and hypoxia markedly increased PK-R2 expression, whereas mRNA levels of PK-R1 remained unchanged [1].

High impact information on PROKR2

  • We show that a targeted null mutation of Prokr2 disrupts circadian coordination of the activity cycle and thermoregulation [2].
  • There was no temporal variation in expression of PK2, PKR1, or PKR2 [3].
  • These suggest that the antiapoptotic effect of PK-1 on LEC may be mediated via PK-R2 [1].
  • These results suggest an intrinsic PK2 neurotransmission and functionally distinct roles for PKR2-expressing neurons in the SCN [4].
  • In addition, one of the patients heterozygous for a PROKR2 mutation was also carrying a missense mutation in KAL1, thus indicating a possible digenic inheritance of the disease in this individual [5].

Biological context of PROKR2


Anatomical context of PROKR2


Associations of PROKR2 with chemical compounds


Other interactions of PROKR2

  • In this study, we report the molecular identification of two endogenous prokineticin receptors, designated PK-R1 and PK-R2, through a search of the human genomic DNA database [6].
  • Prokineticins (PKs), multifunctional secreted proteins, activate two endogenous G protein-coupled receptors (R) termed PK-R1 and PK-R2 [8].


  1. Prokineticins (endocrine gland-derived vascular endothelial growth factor and BV8) in the bovine ovary: expression and role as mitogens and survival factors for corpus luteum-derived endothelial cells. Kisliouk, T., Podlovni, H., Spanel-Borowski, K., Ovadia, O., Zhou, Q.Y., Meidan, R. Endocrinology (2005) [Pubmed]
  2. Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Prosser, H.M., Bradley, A., Chesham, J.E., Ebling, F.J., Hastings, M.H., Maywood, E.S. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  3. Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle. Battersby, S., Critchley, H.O., Morgan, K., Millar, R.P., Jabbour, H.N. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  4. Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus. Masumoto, K.H., Nagano, M., Takashima, N., Hayasaka, N., Hiyama, H., Matsumoto, S., Inouye, S.T., Shigeyoshi, Y. Eur. J. Neurosci. (2006) [Pubmed]
  5. Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. Dod??, C., Teixeira, L., Levilliers, J., Fouveaut, C., Bouchard, P., Kottler, M.L., Lespinasse, J., Lienhardt-Roussie, A., Mathieu, M., Moerman, A., Morgan, G., Murat, A., Toublanc, J.E., Wolczynski, S., Delpech, M., Petit, C., Young, J., Hardelin, J.P. PLoS Genet. (2006) [Pubmed]
  6. Molecular cloning and characterization of prokineticin receptors. Soga, T., Matsumoto, S., Oda, T., Saito, T., Hiyama, H., Takasaki, J., Kamohara, M., Ohishi, T., Matsushime, H., Furuichi, K. Biochim. Biophys. Acta (2002) [Pubmed]
  7. Endocrine gland-derived vascular endothelial growth factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma. Ngan, E.S., Lee, K.Y., Yeung, W.S., Ngan, H.Y., Ng, E.H., Ho, P.C. Endocrinology (2006) [Pubmed]
  8. Differential expression of prokineticin receptors by endothelial cells derived from different vascular beds: a physiological basis for distinct endothelial function. Podlovni, H., Ovadia, O., Kisliouk, T., Klipper, E., Zhou, Q.Y., Friedman, A., Alfaidy, N., Meidan, R. Cell. Physiol. Biochem. (2006) [Pubmed]
  9. The genetic system of the L-type pyruvate kinase forms in man. Subunit structure, interrelation and kinetic characteristics of the pyruvate kinase enzymes from erythrocytes and liver. Kahn, A., Marie, J., Garreau, H., Sprengers, E.D. Biochim. Biophys. Acta (1978) [Pubmed]
  10. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. Pasquali, D., Rossi, V., Staibano, S., De Rosa, G., Chieffi, P., Prezioso, D., Mirone, V., Mascolo, M., Tramontano, D., Bellastella, A., Sinisi, A.A. Endocrinology (2006) [Pubmed]
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