Disease relevance of PROKR2

• Stress conditions such as serum withdrawal, TNF-alpha, and hypoxia markedly increased PK-R2 expression, whereas mRNA levels of PK-R1 remained unchanged [1].

High impact information on PROKR2

• We show that a targeted null mutation of Prokr2 disrupts circadian coordination of the activity cycle and thermoregulation [2].
• There was no temporal variation in expression of PK2, PKR1, or PKR2 [3].
• These suggest that the antiapoptotic effect of PK-1 on LEC may be mediated via PK-R2 [1].
• These results suggest an intrinsic PK2 neurotransmission and functionally distinct roles for PKR2-expressing neurons in the SCN [4].
• In addition, one of the patients heterozygous for a PROKR2 mutation was also carrying a missense mutation in KAL1, thus indicating a possible digenic inheritance of the disease in this individual [5].

Biological context of PROKR2

• PK-R1, locating in chromosome 2, and PK-R2, locating in chromosome 20p13, shared 87% homology, which was an extremely high value among known GPCRs [6].
• Tissue distribution analysis revealed that expression of PK-R1 was observed in the testis, medulla oblongata, skeletal muscle and skin, while that of PK-R2 showed preferential expression in the central nervous system [6].

Anatomical context of PROKR2

• Subsequent expression analyses on the EG-VEGF receptors showed that hPK-R1 and hPK-R2 are differentially expressed in human endometrium, but show no significant correlation with the hormonal treatments [7].
• Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus [4].
• Corpus luteum (CL)-derived EC (LEC) expressed both PK-R1 and PK-R2 [8].
• Liver (L-type) pyruvate kinase is composed of 4 identical L subunits while the major form of erythrocyte enzyme (PK-R2) is a heterotetramer designated as L2L2', the molecular weight of L' being slightly higher than that of L subunits (63 000 and 58 000 respectively) [9].

Associations of PROKR2 with chemical compounds

• PK-R1 and PK-R2 were found in NPEC, EPN, and CPEC [10].

Other interactions of PROKR2

• In this study, we report the molecular identification of two endogenous prokineticin receptors, designated PK-R1 and PK-R2, through a search of the human genomic DNA database [6].
• Prokineticins (PKs), multifunctional secreted proteins, activate two endogenous G protein-coupled receptors (R) termed PK-R1 and PK-R2 [8].

References