Gene Review:
Dhcr7 - 7-dehydrocholesterol reductase
Mus musculus
Synonyms:
7-DHC reductase, AA409147, Sterol Delta(7)-reductase
- Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness. Kovarova, M., Wassif, C.A., Odom, S., Liao, K., Porter, F.D., Rivera, J. J. Exp. Med. (2006)
- Immunohistochemical and microarray analyses of a mouse model for the smith-lemli-opitz syndrome. Waage-Baudet, H., Dunty, W.C., Dehart, D.B., Hiller, S., Sulik, K.K. Dev. Neurosci. (2005)
- 7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome. Fitzky, B.U., Moebius, F.F., Asaoka, H., Waage-Baudet, H., Xu, L., Xu, G., Maeda, N., Kluckman, K., Hiller, S., Yu, H., Batta, A.K., Shefer, S., Chen, T., Salen, G., Sulik, K., Simoni, R.D., Ness, G.C., Glossmann, H., Patel, S.B., Tint, G.S. J. Clin. Invest. (2001)
- Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. Correa-Cerro, L.S., Wassif, C.A., Kratz, L., Miller, G.F., Munasinghe, J.P., Grinberg, A., Fliesler, S.J., Porter, F.D. Hum. Mol. Genet. (2006)
- Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvature. Gondré-Lewis, M.C., Petrache, H.I., Wassif, C.A., Harries, D., Parsegian, A., Porter, F.D., Loh, Y.P. J. Cell. Sci. (2006)
- The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. Tint, G.S., Yu, H., Shang, Q., Xu, G., Patel, S.B. J. Lipid Res. (2006)
- Partial rescue of neonatal lethality of Dhcr7 null mice by a nestin promoter-driven DHCR7 transgene expression. Yu, H., Wessels, A., Tint, G.S., Patel, S.B. Brain Res. Dev. Brain Res. (2005)
- Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. Yu, H., Wessels, A., Chen, J., Phelps, A.L., Oatis, J., Tint, G.S., Patel, S.B. BMC Dev. Biol. (2004)
- Abnormal serotonergic development in a mouse model for the Smith-Lemli-Opitz syndrome: implications for autism. Waage-Baudet, H., Lauder, J.M., Dehart, D.B., Kluckman, K., Hiller, S., Tint, G.S., Sulik, K.K. Int. J. Dev. Neurosci. (2003)
- RPR 101821, a new potent cholesterol-lowering agent: inhibition of squalene synthase and 7-dehydrocholesterol reductase. Amin, D., Rutledge, R.Z., Needle, S.J., Hele, D.J., Neuenswander, K., Bush, R.C., Bilder, G.E., Perrone, M.H. Naunyn Schmiedebergs Arch. Pharmacol. (1996)