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Gene Review

Nes  -  nestin

Mus musculus

Synonyms: AA166324, C78523, ESTM46, Nestin
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Disease relevance of Nes


Psychiatry related information on Nes


High impact information on Nes


Chemical compound and disease context of Nes


Biological context of Nes


Anatomical context of Nes


Associations of Nes with chemical compounds


Regulatory relationships of Nes


Other interactions of Nes

  • In embryonic stages, E9-12, anti-ELF localized to the primary brain vesicular cells that also labeled strongly with anti-nestin but not anti-vimentin [15].
  • In desmin K/O mice nestin was also found in regenerating myofibers [11].
  • Embryonic LHRH neurons were examined in vivo for Mash-1 and nestin, two factors that delineate precursor populations in PNS and forebrain CNS cells [16].
  • Experimental manipulation of nasal explants revealed dual expression of nestin protein and LHRH in cells proximal to the vomeronasal organ anlage that was dependent upon midline cartilaginous/mesenchymal tissues [16].
  • We identified Pitx2 expression in nestin-positive neural progenitors and in postmitotic, developing neurons [24].

Analytical, diagnostic and therapeutic context of Nes


  1. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. Kronenberg, G., Wang, L.P., Synowitz, M., Gertz, K., Katchanov, J., Glass, R., Harms, C., Kempermann, G., Kettenmann, H., Endres, M. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  2. Localization of nerve growth factor, neurotrophin-3, and glial cell line-derived neurotrophic factor in nestin-expressing reactive astrocytes in the caudate-putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/Bl mice. Chen, L.W., Zhang, J.P., Kwok-Yan Shum, D., Chan, Y.S. J. Comp. Neurol. (2006) [Pubmed]
  3. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Yan, C.T., Kaushal, D., Murphy, M., Zhang, Y., Datta, A., Chen, C., Monroe, B., Mostoslavsky, G., Coakley, K., Gao, Y., Mills, K.D., Fazeli, A.P., Tepsuporn, S., Hall, G., Mulligan, R., Fox, E., Bronson, R., De Girolami, U., Lee, C., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Dunn, K.J., Williams, B.O., Li, Y., Pavan, W.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. Uhrbom, L., Kastemar, M., Johansson, F.K., Westermark, B., Holland, E.C. Cancer Res. (2005) [Pubmed]
  6. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. Schmidt, M.V., Deussing, J.M., Oitzl, M.S., Ohl, F., Levine, S., Wurst, W., Holsboer, F., M??ller, M.B., de Kloet, E.R. Eur. J. Neurosci. (2006) [Pubmed]
  7. CNS stem cells express a new class of intermediate filament protein. Lendahl, U., Zimmerman, L.B., McKay, R.D. Cell (1990) [Pubmed]
  8. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y., Okano, H. Nat. Med. (2006) [Pubmed]
  9. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Reynolds, B.A., Weiss, S. Science (1992) [Pubmed]
  10. Significant up-regulation of nestin protein in the neostriatum of MPTP-treated mice. Are the striatal astrocytes regionally activated after systemic MPTP administration? Chen, L.W., Wei, L.C., Qiu, Y., Liu, H.L., Rao, Z.R., Ju, G., Chan, Y.S. Brain Res. (2002) [Pubmed]
  11. Nestin is expressed during development and in myotendinous and neuromuscular junctions in wild type and desmin knock-out mice. Carlsson, L., Li, Z., Paulin, D., Thornell, L.E. Exp. Cell Res. (1999) [Pubmed]
  12. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. Beech, R.D., Cleary, M.A., Treloar, H.B., Eisch, A.J., Harrist, A.V., Zhong, W., Greer, C.A., Duman, R.S., Picciotto, M.R. J. Comp. Neurol. (2004) [Pubmed]
  13. The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse. Fröjdman, K., Pelliniemi, L.J., Lendahl, U., Virtanen, I., Eriksson, J.E. Differentiation (1997) [Pubmed]
  14. Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells. elshamy, W.M., Ernfors, P. Development (1996) [Pubmed]
  15. ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene. Tang, Y., Katuri, V., Iqbal, S., Narayan, T., Wang, Z., Lu, R.S., Mishra, L., Mishra, B. Oncogene (2002) [Pubmed]
  16. Midline nasal tissue influences nestin expression in nasal-placode-derived luteinizing hormone-releasing hormone neurons during development. Kramer, P.R., Wray, S. Dev. Biol. (2000) [Pubmed]
  17. Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. Liu, Z., Martin, L.J. J. Comp. Neurol. (2003) [Pubmed]
  18. Differential Expression of the Intermediate Filament Protein Nestin during Renal Development and Its Localization in Adult Podocytes. Chen, J., Boyle, S., Zhao, M., Su, W., Takahashi, K., Davis, L., Decaestecker, M., Takahashi, T., Breyer, M.D., Hao, C.M. J. Am. Soc. Nephrol. (2006) [Pubmed]
  19. Presence of endocrine and exocrine markers in EGFP-positive cells from the developing pancreas of a nestin/EGFP mouse. Bernardo, A.S., Barrow, J., Hay, C.W., McCreath, K., Kind, A.J., Schnieke, A.E., Colman, A., Hart, A.W., Docherty, K. Mol. Cell. Endocrinol. (2006) [Pubmed]
  20. Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice. Wei, L.C., Shi, M., Chen, L.W., Cao, R., Zhang, P., Chan, Y.S. Brain Res. Dev. Brain Res. (2002) [Pubmed]
  21. Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells. Blyszczuk, P., Asbrand, C., Rozzo, A., Kania, G., St-Onge, L., Rupnik, M., Wobus, A.M. Int. J. Dev. Biol. (2004) [Pubmed]
  22. Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Tanaka, S., Kamachi, Y., Tanouchi, A., Hamada, H., Jing, N., Kondoh, H. Mol. Cell. Biol. (2004) [Pubmed]
  23. Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice. Rao, G., Pedone, C.A., Valle, L.D., Reiss, K., Holland, E.C., Fults, D.W. Oncogene (2004) [Pubmed]
  24. Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium. Martin, D.M., Skidmore, J.M., Fox, S.E., Gage, P.J., Camper, S.A. Dev. Biol. (2002) [Pubmed]
  25. Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury. Ikeda, R., Kurokawa, M.S., Chiba, S., Yoshikawa, H., Ide, M., Tadokoro, M., Nito, S., Nakatsuji, N., Kondoh, Y., Nagata, K., Hashimoto, T., Suzuki, N. Neurobiol. Dis. (2005) [Pubmed]
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