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Gene Review

Dmc1  -  DMC1 dosage suppressor of mck1 homolog,...

Mus musculus

Synonyms: Dmc1h, Lim15, Mei11, Meiotic recombination protein DMC1/LIM15 homolog, sgdp
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High impact information on Dmc1

  • Meiotic chromosome analysis of Dmc1-deficient mouse spermatocytes revealed random spread of univalent axial elements without correct pairing between homologs [1].
  • The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis [1].
  • We have generated a null mutation in the Dmc1 gene in mice and show that homozygous mutant males and females are sterile with arrest of gametogenesis in the first meiotic prophase [2].
  • Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog [2].
  • The strong similarity of phenotypes in Dmc1-deficient mice and yeast suggests that meiotic mechanisms have been highly conserved through evolution [2].

Biological context of Dmc1

  • The presence of Rad51 and/or Lim15 proteins in early nodules supports the hypothesis that early nodules are involved in recombination-related events during meiosis [3].
  • Thus, the mouse Dmc1 gene is required for homologous synapsis of chromosomes in meiosis [1].
  • In female mice lacking the Dmc1 gene, normal differentiation of oogenesis was aborted in embryos, and germ cells disappeared in the adult ovary [1].
  • This progression may relate to compensatory gene function(s) and/or the observed up-regulation of DNA repair proteins Rad51 and Dmc1 [4].
  • The Lim15 protein, instead, may be involved in recombination in the telomeric region or in cohesion of sister chromatids for segregation [5].

Regulatory relationships of Dmc1

  • 5. Consistent with these results, we find that embryonic ovarian germ cells upregulate the meiotic gene Dmc1 and downregulate the Oct4 transcription factor in an anterior-to-posterior wave [6].

Other interactions of Dmc1

  • Insignificant changes of bouquet frequencies in mice with defects in early stages of DSB repair (Dmc1(-/-), Hop2(-/-)) suggest that there is an ATM-specific influence on bouquet stage duration [7].
  • Rad51 and Dmc1 recombinases are the major players in these processes [8].
  • Mei1 is epistatic to Dmc1 during mouse meiosis [9].
  • Female PGCs obtained from UGRs or genital ridges at 10.5-11.5 dpc began to express meiosis-specific genes, Scp3 and Dmc1, after dissociation and cultivation on feeder cells for several days [10].


  1. The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Yoshida, K., Kondoh, G., Matsuda, Y., Habu, T., Nishimune, Y., Morita, T. Mol. Cell (1998) [Pubmed]
  2. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Pittman, D.L., Cobb, J., Schimenti, K.J., Wilson, L.A., Cooper, D.M., Brignull, E., Handel, M.A., Schimenti, J.C. Mol. Cell (1998) [Pubmed]
  3. RecA-like proteins are components of early meiotic nodules in lily. Anderson, L.K., Offenberg, H.H., Verkuijlen, W.M., Heyting, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis. Tsai-Morris, C.H., Sheng, Y., Lee, E., Lei, K.J., Dufau, M.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Localization of mouse Rad51 and Lim15 proteins on meiotic chromosomes at late stages of prophase 1. Ikeya, T., Shinohara, A., Sato, S., Tabata, S., Ogawa, T. Genes Cells (1996) [Pubmed]
  6. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Menke, D.B., Koubova, J., Page, D.C. Dev. Biol. (2003) [Pubmed]
  7. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Liebe, B., Petukhova, G., Barchi, M., Bellani, M., Braselmann, H., Nakano, T., Pandita, T.K., Jasin, M., Fornace, A., Meistrich, M.L., Baarends, W.M., Schimenti, J., de Lange, T., Keeney, S., Camerini-Otero, R.D., Scherthan, H. Exp. Cell Res. (2006) [Pubmed]
  8. The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. Petukhova, G.V., Pezza, R.J., Vanevski, F., Ploquin, M., Masson, J.Y., Camerini-Otero, R.D. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  9. Mei1 is epistatic to Dmc1 during mouse meiosis. Reinholdt, L.G., Schimenti, J.C. Chromosoma (2005) [Pubmed]
  10. Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Chuma, S., Nakatsuji, N. Dev. Biol. (2001) [Pubmed]
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