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DMC1  -  meiotic recombination protein DMC1-like...

Arabidopsis thaliana

Synonyms: ARABIDOPSIS HOMOLOG OF LILY MESSAGES INDUCED AT MEIOSIS 15, ARABIDOPSIS THALIANA DISRUPTION OF MEIOTIC CONTROL 1, ARLIM15, ATDMC1, DISRUPTION OF MEIOTIC CONTROL 1
 
 
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High impact information on ATDMC1

  • Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exhibited alterations in chromosome segregation during meiosis I and II that resulted in polyads containing from one to eight microspores [1].
  • In this study, our data demonstrate that AtDMC1 function is crucial for meiosis in Arabidopsis [2].
  • Random chromosome segregation without meiotic arrest in both male and female meiocytes of a dmc1 mutant of Arabidopsis [2].
  • Homozygotes for the AtDMC1 insertion failed to express AtDMC1, and their residual fertility was 1.5% that of the wild type [2].
  • Unlike mutations in AtDMC1 and AtSPO11 which also affect bivalent formation as the univalent chromosomes segregate randomly, the dyad univalents formed an ordered metaphase plate and underwent an equational division [3].
 

Biological context of ATDMC1

  • The AtDMC1 promoter was fused to the GUS reporter gene, and conferred meiosis-associated expression in both male and female floral lineages [4].
  • The AtDMC1 gene contains 15 exons and 14 introns [4].
  • Comparison of AtDMC1 isolated from Landsberg erecta ecotype to its Columbia allele ArLIM15, revealed the presence of a 1874 bp transposon-like element within the promoter region of ArLIM15 [4].
  • Structural analysis of a recA-like gene in the genome of Arabidopsis thaliana [5].
  • The amino acid sequence of the putative product of ArLIM15 showed a high degree of similarity to that of LIM15 in the monocotyledonous plant Lilium, including a 93% identity, and to those of other recA-like genes in yeasts and vertebrates with identities of 69-71% [5].
 

Anatomical context of ATDMC1

 

Other interactions of ATDMC1

  • Finally, a synchronisation experiment conducted with the suspension culture indicated that not only AtRAD51 but also AtDMC1 are regulated during the cell cycle, with S-phase-specific induction [6].
 

Analytical, diagnostic and therapeutic context of ATDMC1

  • RT-PCR analysis showed that the expression levels of AtDMC1 and ArLIM15 are similar [4].
  • Based on homologies between the yeast DMC1 and the lily LIM15 meiosis-specific genes, degenerate PCR primers were designed that amplified the Arabidopsis DMC1 gene (AtDMC1) [4].

References

 
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