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Gene Review

Egfbp2  -  epidermal growth factor binding protein...

Mus musculus

Synonyms: EGF-BP B, Egfbp-2, Epidermal growth factor-binding protein type B, Glandular kallikrein K13, Klk-13, ...
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Disease relevance of Egfbp2


High impact information on Egfbp2

  • Interestingly, Klk-13, but not Klk-1, caused a proliferative response of splenic T cells from IQI/Jic mice from the age of 4 weeks onward [2].
  • These results indicate that Klk-13 acts as an autoantigen and may increase T cells responsive to organs commonly expressing Klk-13, playing a pivotal role in the etiology of progression of disease in IQI/Jic mice [2].
  • In addition, remarkably enhanced expression of Klk-13 was observed in the salivary glands of the mice in accordance with the development of inflammatory lesions [2].
  • Western blot analysis using an antiserum against this enzyme gave rise to multiple bands in mouse submandibular glands, suggesting that PRECE is a member of a protease family [3].
  • Mouse submandibular gland prorenin-converting enzyme (PRECE) consists of the two polypeptide chains of 17 and 10 kDa and cleaves mouse Ren-2 prorenin at a dibasic site to yield mature renin [3].

Biological context of Egfbp2


Anatomical context of Egfbp2


Associations of Egfbp2 with chemical compounds

  • A crystal structure of the serine protease, mouse glandular kallikrein 13 (mGK-13) has been determined at 2.6-A resolution [4].

Other interactions of Egfbp2


Analytical, diagnostic and therapeutic context of Egfbp2


  1. Renin activity and angiotensin I concentration in genetically selective inbred line of hypertensive mice. Uddin, M., Harris-Nelson, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome. Takada, K., Takiguchi, M., Konno, A., Inaba, M. J. Biol. Chem. (2005) [Pubmed]
  3. Mouse submandibular gland prorenin-converting enzyme is a member of glandular kallikrein family. Kim, W.S., Nakayama, K., Nakagawa, T., Kawamura, Y., Haraguchi, K., Murakami, K. J. Biol. Chem. (1991) [Pubmed]
  4. The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme). Timm, D.E. Protein Sci. (1997) [Pubmed]
  5. Sequence of an epidermal growth factor-binding protein. Lundgren, S., Ronne, H., Rask, L., Peterson, P.A. J. Biol. Chem. (1984) [Pubmed]
  6. Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis. Nakayama, K., Kim, W.S., Nakagawa, T., Nagahama, M., Murakami, K. J. Biol. Chem. (1990) [Pubmed]
  7. Tissue distribution and characterization of prorenin-converting enzyme in mouse. Nakayama, K., Kim, W.S., Hatsuzawa, K., Hashiba, K., Murakami, K. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  8. Expression of an allozyme of prorenin-converting enzyme in the submandibular gland of DBA/2N mice. Hosoi, K., Tada, J., Tsumura, K., Kanamori, N., Yamanaka, N. J. Biochem. (1998) [Pubmed]
  9. Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22). Kikkawa, Y., Yamanaka, N., Tada, J., Kanamori, N., Tsumura, K., Hosoi, K. Biochim. Biophys. Acta (1998) [Pubmed]
  10. The presence of two types of prorenin converting enzymes in the mouse submandibular gland. Kim, W.S., Nakayama, K., Murakami, K. FEBS Lett. (1991) [Pubmed]
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