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Gene Review

PASD1  -  PAS domain containing 1

Homo sapiens

Synonyms: CT63, Cancer/testis antigen 63, OX-TES-1, OXTES1, PAS domain-containing protein 1
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Disease relevance of PASD1


High impact information on PASD1


Anatomical context of PASD1

  • Expression of PASD1 mRNA was restricted to normal testis, while frequent expression was observed in solid tumours (25 out of 68), thus fulfilling the criteria for a novel cancer testis antigen [2].

Analytical, diagnostic and therapeutic context of PASD1

  • Real-time PCR (RQ-PCR) confirmed the restricted expression of PASD1 in normal donor organs [6].


  1. PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy. Cooper, C.D., Liggins, A.P., Ait-Tahar, K., Roncador, G., Banham, A.H., Pulford, K. Leukemia (2006) [Pubmed]
  2. A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. Liggins, A.P., Brown, P.J., Asker, K., Pulford, K., Banham, A.H. Br. J. Cancer (2004) [Pubmed]
  3. Macrocystic serous adenoma of the pancreas. Khadaroo, R., Knetman, N., Joy, S., Nguyen, G.K. Pathol. Res. Pract. (2002) [Pubmed]
  4. Molecular evolution of PAS domain-containing proteins of filamentous cyanobacteria through domain shuffling and domain duplication. Narikawa, R., Okamoto, S., Ikeuchi, M., Ohmori, M. DNA Res. (2004) [Pubmed]
  5. Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucocutaneous haemorrhages. Quiroga, T., Goycoolea, M., Giesen, P.L., Morales, M., Muñoz, B., Aranda, E., Rodríguez, S., Panes, O., Martínez, C., Pereira, J., Mezzano, D. Pathophysiol. Haemost. Thromb. (2003) [Pubmed]
  6. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. Guinn, B.A., Bland, E.A., Lodi, U., Liggins, A.P., Tobal, K., Petters, S., Wells, J.W., Banham, A.H., Mufti, G.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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