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Gene Review

PHF13  -  PHD finger protein 13

Homo sapiens

Synonyms: MGC43399, PHF5, SPOC1, Survival time-associated PHD finger protein in ovarian cancer 1
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Disease relevance of PHF13

  • This prompted us to systematically examine SPOC1 expression in ovarian cancer in relation to prognosis [1].
  • Interestingly, SPOC1 was associated with residual disease, whereby patients with unresectable tumors showed higher levels compared to patients without residual tumor tissue after surgery (p = 0.029) [1].
  • SPOC1 overexpression was associated with unresectable carcinomas and shorter survival in ovarian cancer [1].

High impact information on PHF13


Biological context of PHF13


Anatomical context of PHF13

  • In goblet cells, actin appeared as a prominent subplasmalemmal sheet lying between granules and the apical membrane, and it disappeared from SPOC1 cells activated by purinergic agonist [6].
  • Here, we summarize the characteristics of SPOC phenomena, especially focusing on the physiological significance of SPOC in cardiac muscle [5].

Associations of PHF13 with chemical compounds

  • SPOC1 cell mucin secretion was not stimulated by forskolin, 8-(4-chlorophenylthio)-adenosine 3',5'-cyclic monophosphate, or 8-bromoguanosine 3',5'-cyclic monophosphate [7].
  • Cultures of SPOC1 cells (L. H. Abdullah, S. W. Davis, L. Burch, M. Yamauchi, S. H. Randell, P. Nettesheim, and C. W. Davis. Biochem. J. 316: 943-951, 1996) secreted mucin on exposure to phorbol 12-myristate 13-acetate (PMA) [apparent affinity (K0.5) approximately 100 nM] and ionomycin (K0.5 approximately 5 microM) almost fivefold over baseline [7].

Other interactions of PHF13


  1. SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer. Mohrmann, G., Hengstler, J.G., Hofmann, T.G., Endele, S.U., Lee, B., Stelzer, C., Zabel, B., Brieger, J., Hasenclever, D., Tanner, B., Sagemueller, J., Sehouli, J., Will, H., Winterpacht, A. Int. J. Cancer (2005) [Pubmed]
  2. Evidence for the involvement of retinoic acid receptor RAR alpha-dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. Zhang, L.X., Mills, K.J., Dawson, M.I., Collins, S.J., Jetten, A.M. J. Biol. Chem. (1995) [Pubmed]
  3. Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif. Trappe, R., Ahmed, M., Gläser, B., Vogel, C., Tascou, S., Burfeind, P., Engel, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  4. The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development. Trappe, R., Schulze, E., Rzymski, T., Fröde, S., Engel, W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  5. Regulation of muscle contraction by Ca2+ and ADP: focusing on the auto-oscillation (SPOC). Ishiwata, S., Shimamoto, Y., Suzuki, M., Sasaki, D. Adv. Exp. Med. Biol. (2007) [Pubmed]
  6. Barrier role of actin filaments in regulated mucin secretion from airway goblet cells. Ehre, C., Rossi, A.H., Abdullah, L.H., De Pestel, K., Hill, S., Olsen, J.C., Davis, C.W. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  7. Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cells. Abdullah, L.H., Conway, J.D., Cohn, J.A., Davis, C.W. Am. J. Physiol. (1997) [Pubmed]
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