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Gene Review

UL83  -  lower matrix protein; involved in immune...

Human herpesvirus 5

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Disease relevance of HHV5gp078


High impact information on HHV5gp078

  • These ORFs, in the HindIII C fragment of MCMV, are colinear with the UL82, UL83, and UL84 ORFs of HCMV [2].
  • Large amounts of pp65 (UL83) of human cytomegalovirus are translocated to the cell nucleus during the first minutes after uptake of the tegument protein from infecting viral particles [3].
  • Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport [3].
  • CMV-specific CD8(+) T cell counts were monitored, using HLA-A2 tetrameric complexes, to establish the level of immune response to the viral phosphoprotein UL83 in patients after allogeneic SCT [4].
  • CMV-MVA immunization potently induced both humoral and cellular immunity to sUL55, UL83 and UL123 after murine immunization, and cellular immunity to UL83 and UL123 by in vitro amplification of T cell recall responses in human PBMC [5].

Chemical compound and disease context of HHV5gp078


Biological context of HHV5gp078

  • Soluble (s) UL55 (surface glycoprotein), UL83 (tegument protein) and UL123/e4 (nuclear protein) are immunodominant in eliciting both CMV nAb and cellular immunity [5].
  • DNA sequence analysis of the Eco R I "C" fragment of the GPCMV genome identified an open reading frame (ORF) which is colinear with that of the HCMV tegument phosphoprotein, UL83 (pp65) [7].
  • CONCLUSION :Humoral immunity to HCMV protein UL83 may be relevant to the etiopathogenesis of scleroderma [8].
  • With pp65 antigenemia assay as the "gold standard", nested PCR for morphological transforming region II (mtr II) and glycoprotein O (gO) gene and uniplex PCR for UL 83 gene were applied on 92 consecutive clinical specimens obtained from 74 immunocompromised patients with clinically suspected HCMV disease [9].

Anatomical context of HHV5gp078


Associations of HHV5gp078 with chemical compounds

  • Transcriptional analyses revealed that a GPCMV UL83 probe hybridized with both 2.2 kb and 4.2 kb mRNA species at 48 h post-infection (p.i.); synthesis of these messages was blocked by phosphonoacetic acid (PAA), defining these as "late" gene transcripts [7].

Analytical, diagnostic and therapeutic context of HHV5gp078

  • The dominant phosphoprotein pp65 (UL83) of human cytomegalovirus is dispensable for growth in cell culture [10].
  • RESULTS: We generated CMV-MVA via homologous recombination, and demonstrated high expression levels of sUL55, UL83 and UL123/e4 by Western blot [5].
  • A multiplex PCR combining the primers targeting three regions of the HCMV genome, viz. the morphological transforming region II (mtr II), UL-83 and glycoprotein O (gO) genes for the detection of the genome of HCMV was standardized with HCMV AD169 strain [11].
  • Immunofluorescence experiments revealed that the putative GPCMV UL83 homolog exhibited a predominantly nuclear localization pattern [7].
  • IgG antibodies to UL83 were measured by an enzyme-linked immunosorbent assay (ELISA) [8].


  1. Stably expressed antisense RNA to cytomegalovirus UL83 inhibits viral replication. Dal Monte, P., Bessia, C., Ripalti, A., Landini, M.P., Topilko, A., Plachter, B., Virelizier, J.L., Michelson, S. J. Virol. (1996) [Pubmed]
  2. Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins. Cranmer, L.D., Clark, C.L., Morello, C.S., Farrell, H.E., Rawlinson, W.D., Spector, D.H. J. Virol. (1996) [Pubmed]
  3. Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport. Schmolke, S., Drescher, P., Jahn, G., Plachter, B. J. Virol. (1995) [Pubmed]
  4. Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants. Aubert, G., Hassan-Walker, A.F., Madrigal, J.A., Emery, V.C., Morte, C., Grace, S., Koh, M.B., Potter, M., Prentice, H.G., Dodi, I.A., Travers, P.J. J. Infect. Dis. (2001) [Pubmed]
  5. Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infection. Wang, Z., La Rosa, C., Lacey, S.F., Maas, R., Mekhoubad, S., Britt, W.J., Diamond, D.J. J. Clin. Virol. (2006) [Pubmed]
  6. Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83. Schleiss, M.R., Bourne, N., Jensen, N.J., Bravo, F., Bernstein, D.I. Viral Immunol. (2000) [Pubmed]
  7. Molecular characterization of the guinea pig cytomegalovirus UL83 (pp65) protein homolog. Schleiss, M.R., McGregor, A., Jensen, N.J., Erdem, G., Aktan, L. Virus Genes (1999) [Pubmed]
  8. Antibodies to human cytomegalovirus protein UL83 in systemic sclerosis. Namboodiri, A.M., Rocca, K.M., Kuwana, M., Pandey, J.P. Clin. Exp. Rheumatol. (2006) [Pubmed]
  9. Evaluation of three polymerase chain reaction tests targeting morphological transforming region II, UL-83 gene and glycoprotein O gene for the detection of human cytomegalovirus genome in clinical specimens of immunocompromised patients in Chennai, India. Sowmya, P., Madhavan, H.N., Therese, K.L. Virol. J. (2006) [Pubmed]
  10. The dominant phosphoprotein pp65 (UL83) of human cytomegalovirus is dispensable for growth in cell culture. Schmolke, S., Kern, H.F., Drescher, P., Jahn, G., Plachter, B. J. Virol. (1995) [Pubmed]
  11. Development and application of a novel multiplex polymerase chain reaction for semi-quantitation of Human Cytomegalovirus in clinical specimens. Madhavan, H.N., Sowmya, P., Therese, K.L., Malathi, J. J. Virol. Methods (2007) [Pubmed]
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