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Disease relevance of Stuttering


Psychiatry related information on Stuttering


High impact information on Stuttering

  • Betaxolol and stuttering [9].
  • Bethanecol chloride in treatment of stuttering [10].
  • A stuttering or slippage model to account for these events has been further refined to include a pressure which displaces the nascent strand in a given direction once it has disengaged from the template, and the similarities of this model to those which account for readthrough of cellular RNA polymerase transcription blocks are discussed [11].
  • The G insertions always occur within a short run of Gs, and a stuttering mechanism for the insertions has been suggested in which the viral polymerase reiteratively copies a template C residue during mRNA synthesis [12].
  • Stuttering caused by gabapentin [13].

Chemical compound and disease context of Stuttering


Biological context of Stuttering


Anatomical context of Stuttering

  • Influence of some psychopharmaca on the increase of the amplitude of electrically induced monosynaptic spinal cord reflex during the paroxysm of stuttering. II. Effect of chlorpromazine [22].
  • The main dysfunction is thought to be an impairment in the ability of the basal ganglia to produce timing cues for the initiation of the next motor segment of speech, explaining the association of acquired and re-emergent stuttering with diseases such as dystonia and Parkinson's disease [23].

Gene context of Stuttering


Analytical, diagnostic and therapeutic context of Stuttering


  1. Stilboestrol and stuttering priapism in homozygous sickle-cell disease. Serjeant, G.R., de Ceulaer, K., Maude, G.H. Lancet (1985) [Pubmed]
  2. Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication. Zheng, H., Lee, H.A., Palese, P., García-Sastre, A. J. Virol. (1999) [Pubmed]
  3. Developmental stuttering and Parkinson's disease: the effects of levodopa treatment. Anderson, J.M., Hughes, J.D., Rothi, L.J., Crucian, G.P., Heilman, K.M. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  4. Familial relationship between Gilles de la Tourette's syndrome, attention deficit disorder, learning disabilities, speech disorders, and stuttering. Pauls, D.L., Leckman, J.F., Cohen, D.J. Journal of the American Academy of Child and Adolescent Psychiatry. (1993) [Pubmed]
  5. Language-induced epilepsy, acquired stuttering, and idiopathic generalized epilepsy: phenotypic study of one family. Valenti, M.P., Rudolf, G., Carré, S., Vrielynck, P., Thibault, A., Szepetowski, P., Hirsch, E. Epilepsia (2006) [Pubmed]
  6. Bilateral globus pallidus lesions in a patient with Tourette syndrome and related disorders. Demirkol, A., Erdem, H., Inan, L., Yigit, A., Güney, M. Biol. Psychiatry (1999) [Pubmed]
  7. Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1. Comings, D.E., Wu, S., Chiu, C., Ring, R.H., Gade, R., Ahn, C., MacMurray, J.P., Dietz, G., Muhleman, D. Am. J. Med. Genet. (1996) [Pubmed]
  8. Aphasia, apraxia and neurogenic stuttering as complications of metrizamide myelography (speech deficits following myelography). Pimental, P.A., Gorelick, P.B. Acta neurologica Scandinavica. (1985) [Pubmed]
  9. Betaxolol and stuttering. Burris, J.F., Riggs, M.C., Brinkley, R.R. Lancet (1990) [Pubmed]
  10. Bethanecol chloride in treatment of stuttering. Hays, P. Lancet (1987) [Pubmed]
  11. Paramyxovirus mRNA editing leads to G deletions as well as insertions. Jacques, J.P., Hausmann, S., Kolakofsky, D. EMBO J. (1994) [Pubmed]
  12. A stuttering model for paramyxovirus P mRNA editing. Vidal, S., Curran, J., Kolakofsky, D. EMBO J. (1990) [Pubmed]
  13. Stuttering caused by gabapentin. Nissani, M., Sanchez, E.A. Ann. Intern. Med. (1997) [Pubmed]
  14. A mutant RNA polymerase reveals a kinetic mechanisms for the switch between nonproductive stuttering synthesis and productive initiation during promoter clearance. Jin, D.J. J. Biol. Chem. (1996) [Pubmed]
  15. The effect of haloperidol on stuttering. Rosenberger, P.B., Wheelden, J.A., Kalotkin, M. The American journal of psychiatry. (1976) [Pubmed]
  16. Lack of effect of clonidine on stuttering in children. Althaus, M., Vink, H.J., Minderaa, R.B., Goorhuis-Brouwer, S.M., Oosterhoff, M.D. The American journal of psychiatry. (1995) [Pubmed]
  17. Propranolol and stuttering. Cocores, J.A., Dackis, C.A., Davies, R.K., Gold, M.S. The American journal of psychiatry. (1986) [Pubmed]
  18. Treatment of stuttering with phenelzine. Oberlander, E., Schneier, F., Liebowitz, M.R. The American journal of psychiatry. (1993) [Pubmed]
  19. Unusual heterogeneity of the 5'-termini of human adenovirus type 2 early region E2 mRNA. Hashimoto, S., Green, M. Nucleic Acids Res. (1984) [Pubmed]
  20. Neuropharmacology of theophylline induced stuttering: the role of dopamine, adenosine and GABA. Movsessian, P. Med. Hypotheses (2005) [Pubmed]
  21. Homosexuality treated adventitiously in a stuttering therapy program: a case report presenting a heterophobic orientation. Porter, J.F. The Australian and New Zealand journal of psychiatry. (1976) [Pubmed]
  22. Influence of some psychopharmaca on the increase of the amplitude of electrically induced monosynaptic spinal cord reflex during the paroxysm of stuttering. II. Effect of chlorpromazine. Lastovka, M. Folia phoniatrica. (1979) [Pubmed]
  23. Adult-onset re-emergent stuttering as a presentation of Parkinson's disease. Lim, E.C., Wilder-Smith, E., Ong, B.K., Seet, R.C. Ann. Acad. Med. Singap. (2005) [Pubmed]
  24. Chemical modification of nucleotide bases and mRNA editing depend on hexamer or nucleoprotein phase in Sendai virus nucleocapsids. Iseni, F., Baudin, F., Garcin, D., Marq, J.B., Ruigrok, R.W., Kolakofsky, D. RNA (2002) [Pubmed]
  25. Nucleotide sequences and mapping of novel heterogenous 5'-termini of adenovirus 2 early region 4 mRNA. Hashimoto, S., Pursley, M.H., Green, M. Nucleic Acids Res. (1981) [Pubmed]
  26. An unusual large intergenic region in the S-RNA of a Bulgarian tomato spotted wilt virus isolate. Heinze, C., Willingmann, P., Schwach, F., Adam, G. Arch. Virol. (2003) [Pubmed]
  27. Adult-onset stuttering treated with anticonvulsants. Baratz, R., Mesulam, M.M. Arch. Neurol. (1981) [Pubmed]
  28. A positron emission tomography [18F]deoxyglucose study of developmental stuttering. Wu, J.C., Maguire, G., Riley, G., Fallon, J., LaCasse, L., Chin, S., Klein, E., Tang, C., Cadwell, S., Lottenberg, S. Neuroreport (1995) [Pubmed]
  29. Management of child and adolescent stuttering with olanzapine: three case reports. Lavid, N., Franklin, D.L., Maguire, G.A. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. (1999) [Pubmed]
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