Gene Review:
Mlh1 - mutL homolog 1 (E. coli)
Mus musculus
Synonyms:
1110035C23Rik, AI317206, AI325952, AI561766, DNA mismatch repair protein Mlh1, ...
- Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Yao, X., Buermeyer, A.B., Narayanan, L., Tran, D., Baker, S.M., Prolla, T.A., Glazer, P.M., Liskay, R.M., Arnheim, N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. Edelmann, W., Yang, K., Kuraguchi, M., Heyer, J., Lia, M., Kneitz, B., Fan, K., Brown, A.M., Lipkin, M., Kucherlapati, R. Cancer Res. (1999)
- Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Shoemaker, A.R., Haigis, K.M., Baker, S.M., Dudley, S., Liskay, R.M., Dove, W.F. Oncogene (2000)
- Tumor-associated Apc mutations in Mlh1-/- Apc1638N mice reveal a mutational signature of Mlh1 deficiency. Kuraguchi, M., Edelmann, W., Yang, K., Lipkin, M., Kucherlapati, R., Brown, A.M. Oncogene (2000)
- Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Baker, S.M., Plug, A.W., Prolla, T.A., Bronner, C.E., Harris, A.C., Yao, X., Christie, D.M., Monell, C., Arnheim, N., Bradley, A., Ashley, T., Liskay, R.M. Nat. Genet. (1996)
- Crossover and noncrossover pathways in mouse meiosis. Guillon, H., Baudat, F., Grey, C., Liskay, R.M., de Massy, B. Mol. Cell (2005)
- Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mihaylova, V.T., Bindra, R.S., Yuan, J., Campisi, D., Narayanan, L., Jensen, R., Giordano, F., Johnson, R.S., Rockwell, S., Glazer, P.M. Mol. Cell. Biol. (2003)
- Mouse models for colorectal cancer. Heyer, J., Yang, K., Lipkin, M., Edelmann, W., Kucherlapati, R. Oncogene (1999)
- Analyzing tumor suppressor activities in the murine small intestine. Clarke, A.R., Sansom, O.J. Oncol. Res. (2003)
- Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. Takagi, Y., Takahashi, M., Sanada, M., Ito, R., Yamaizumi, M., Sekiguchi, M. DNA Repair (Amst.) (2003)
- Mlh1 can function in antibody class switch recombination independently of Msh2. Schrader, C.E., Vardo, J., Stavnezer, J. J. Exp. Med. (2003)
- Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo. Sansom, O.J., Bishop, S.M., Court, H., Dudley, S., Liskay, R.M., Clarke, A.R. DNA Repair (Amst.) (2003)
- Chromosomal influence on meiotic spindle assembly: abnormal meiosis I in female Mlh1 mutant mice. Woods, L.M., Hodges, C.A., Baart, E., Baker, S.M., Liskay, M., Hunt, P.A. J. Cell Biol. (1999)
- The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Jenab-Wolcott, J., Rodriguez-Correa, D., Reitmair, A.H., Mak, T., Rosenberg, N. Mol. Cell. Biol. (2000)
- The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Berry, S.E., Garces, C., Hwang, H.S., Kunugi, K., Meyers, M., Davis, T.W., Boothman, D.A., Kinsella, T.J. Cancer Res. (1999)
- MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Sansom, O.J., Zabkiewicz, J., Bishop, S.M., Guy, J., Bird, A., Clarke, A.R. Oncogene (2003)
- A role for mismatch repair in control of DNA ploidy following DNA damage. Strathdee, G., Sansom, O.J., Sim, A., Clarke, A.R., Brown, R. Oncogene (2001)
- Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. Yang, K., Fan, K.H., Lamprecht, S.A., Edelmann, W., Kopelovich, L., Kucherlapati, R., Lipkin, M. Int. J. Cancer (2005)
- Accelerated growth of intestinal tumours after radiation exposure in Mlh1-knockout mice: evaluation of the late effect of radiation on a mouse model of HNPCC. Tokairin, Y., Kakinuma, S., Arai, M., Nishimura, M., Okamoto, M., Ito, E., Akashi, M., Miki, Y., Kawano, T., Iwai, T., Shimada, Y. International journal of experimental pathology. (2006)
- Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Kolas, N.K., Svetlanov, A., Lenzi, M.L., Macaluso, F.P., Lipkin, S.M., Liskay, R.M., Greally, J., Edelmann, W., Cohen, P.E. J. Cell Biol. (2005)
- Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. Schrader, C.E., Edelmann, W., Kucherlapati, R., Stavnezer, J. J. Exp. Med. (1999)
- DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Trinh, B.N., Long, T.I., Nickel, A.E., Shibata, D., Laird, P.W. Mol. Cell. Biol. (2002)
- Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Xu, X., Aprelikova, O., Moens, P., Deng, C.X., Furth, P.A. Development (2003)
- Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. Schrader, C.E., Vardo, J., Stavnezer, J. J. Exp. Med. (2002)
- Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells. Baross-Francis, A., Makhani, N., Liskay, R.M., Jirik, F.R. Oncogene (2001)