The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Aicda  -  activation-induced cytidine deaminase

Mus musculus

Synonyms: Activation-induced cytidine deaminase, Aid, Arp2, Cytidine aminohydrolase, Single-stranded DNA cytosine deaminase
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Aicda


High impact information on Aicda


Biological context of Aicda


Anatomical context of Aicda


Associations of Aicda with chemical compounds


Other interactions of Aicda


Analytical, diagnostic and therapeutic context of Aicda


  1. A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Gourzi, P., Leonova, T., Papavasiliou, F.N. Immunity (2006) [Pubmed]
  2. Unmutated immunoglobulin M can protect mice from death by influenza virus infection. Harada, Y., Muramatsu, M., Shibata, T., Honjo, T., Kuroda, K. J. Exp. Med. (2003) [Pubmed]
  3. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Kotani, A., Kakazu, N., Tsuruyama, T., Okazaki, I.M., Muramatsu, M., Kinoshita, K., Nagaoka, H., Yabe, D., Honjo, T. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. N-wasp involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Legg, J.A., Bompard, G., Dawson, J., Morris, H.L., Andrew, N., Cooper, L., Johnston, S.A., Tramountanis, G., Machesky, L.M. Mol. Biol. Cell (2007) [Pubmed]
  5. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., Honjo, T. Cell (2000) [Pubmed]
  6. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Chaudhuri, J., Tian, M., Khuong, C., Chua, K., Pinaud, E., Alt, F.W. Nature (2003) [Pubmed]
  7. The AID enzyme induces class switch recombination in fibroblasts. Okazaki, I.M., Kinoshita, K., Muramatsu, M., Yoshikawa, K., Honjo, T. Nature (2002) [Pubmed]
  8. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Dudley, D.D., Chaudhuri, J., Bassing, C.H., Alt, F.W. Adv. Immunol. (2005) [Pubmed]
  9. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Sayegh, C.E., Quong, M.W., Agata, Y., Murre, C. Nat. Immunol. (2003) [Pubmed]
  10. Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase. Frasca, D., Van der Put, E., Riley, R.L., Blomberg, B.B. J. Immunol. (2004) [Pubmed]
  11. Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene. Yadav, A., Olaru, A., Saltis, M., Setren, A., Cerny, J., Livák, F. Mol. Immunol. (2006) [Pubmed]
  12. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Imai, K., Slupphaug, G., Lee, W.I., Revy, P., Nonoyama, S., Catalan, N., Yel, L., Forveille, M., Kavli, B., Krokan, H.E., Ochs, H.D., Fischer, A., Durandy, A. Nat. Immunol. (2003) [Pubmed]
  13. RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells. Eto, T., Kinoshita, K., Yoshikawa, K., Muramatsu, M., Honjo, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  14. Constitutive expression of AID leads to tumorigenesis. Okazaki, I.M., Hiai, H., Kakazu, N., Yamada, S., Muramatsu, M., Kinoshita, K., Honjo, T. J. Exp. Med. (2003) [Pubmed]
  15. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Casola, S., Cattoretti, G., Uyttersprot, N., Koralov, S.B., Segal, J., Hao, Z., Waisman, A., Egert, A., Ghitza, D., Rajewsky, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. Muramatsu, M., Sankaranand, V.S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N.O., Honjo, T. J. Biol. Chem. (1999) [Pubmed]
  17. Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice. Nilsen, H., An, Q., Lindahl, T. Oncogene (2005) [Pubmed]
  18. Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. Jansen, J.G., Langerak, P., Tsaalbi-Shtylik, A., van den Berk, P., Jacobs, H., de Wind, N. J. Exp. Med. (2006) [Pubmed]
  19. De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination. Begum, N.A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R., Honjo, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. Morgan, H.D., Dean, W., Coker, H.A., Reik, W., Petersen-Mahrt, S.K. J. Biol. Chem. (2004) [Pubmed]
  21. Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. Ronai, D., Iglesias-Ussel, M.D., Fan, M., Li, Z., Martin, A., Scharff, M.D. J. Exp. Med. (2007) [Pubmed]
  22. Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells. Horikawa, K., Kaku, H., Nakajima, H., Davey, H.W., Hennighausen, L., Iwamoto, I., Yasue, T., Kariyone, A., Takatsu, K. J. Immunol. (2001) [Pubmed]
  23. Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. Bardwell, P.D., Martin, A., Wong, E., Li, Z., Edelmann, W., Scharff, M.D. J. Immunol. (2003) [Pubmed]
  24. The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system. Krause, K., Marcu, K.B., Greeve, J. Mol. Immunol. (2006) [Pubmed]
  25. Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. Martin, A., Li, Z., Lin, D.P., Bardwell, P.D., Iglesias-Ussel, M.D., Edelmann, W., Scharff, M.D. J. Exp. Med. (2003) [Pubmed]
  26. A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway. Seagal, J., Edry, E., Keren, Z., Leider, N., Benny, O., Machluf, M., Melamed, D. J. Exp. Med. (2003) [Pubmed]
  27. Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat. Khamlichi, A.A., Glaudet, F., Oruc, Z., Denis, V., Le Bert, M., Cogné, M. Blood (2004) [Pubmed]
  28. Increased transcription levels induce higher mutation rates in a hypermutating cell line. Bachl, J., Carlson, C., Gray-Schopfer, V., Dessing, M., Olsson, C. J. Immunol. (2001) [Pubmed]
WikiGenes - Universities