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Gene Review

DNASE1L2  -  deoxyribonuclease I-like 2

Homo sapiens

Synonyms: DHP1, DNAS1L2, DNase I homolog protein DHP1, DNase I-like 2, Deoxyribonuclease I-like 2, ...
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Disease relevance of DNASE1L2


High impact information on DNASE1L2


Biological context of DNASE1L2


Associations of DNASE1L2 with chemical compounds

  • Stability to DHP-1 was improved by methyl substitution in the isoxazoline ring, but at the expense of antibacterial activity [8].
  • They are particularly active against community-acquired respiratory tract pathogens and have stabilities to DHP-1 superior to that of meropenem [9].
  • The isoxazoline and isoxazolidine compounds showed potent antibacterial activity but moderate stability to human dehydropeptidase 1 (DHP-1) [8].
  • The adsorption capacities of polymer-coated activated charcoal (DHP-1 and Adsorba 150C), uncharged resin (Amberlite XAD-7), anion exchange resin (Dowex-1) and polymyxin B matrix were assessed by measurement of the equilibrium adsorption isotherms for SEA [10].
  • A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined [11].

Other interactions of DNASE1L2


Analytical, diagnostic and therapeutic context of DNASE1L2

  • Northern analysis revealed DNAS1L3 expression nearly exclusively in liver, while DNAS1L2 expression was detected in brain by RT-PCR [5].
  • In Western blot analysis, hg303 recognizes both wild type and C-terminal Myc-His-tagged human DNase gamma, but does not cross-react with human DNase I family members, DNase I, DNase X, or DNAS1L2 [13].
  • Over 4 h perfusion, DHP-1 charcoal removed 50% of the initial amount of 125I-SEA, Adsorba 150C charcoal 8.1% of SEA and Amberlite XAD-7 resin 32.5% of SEA [10].


  1. A comparison of hemoperfusion columns for paraquat. Talbot, A.R. Veterinary and human toxicology. (1989) [Pubmed]
  2. De novo design of an IL-4 antagonist and its structure at 1.9 A. Laporte, S.L., Forsyth, C.M., Cunningham, B.C., Miercke, L.J., Akhavan, D., Stroud, R.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. Shiokawa, D., Tanuma, S. Biochemistry (2001) [Pubmed]
  4. Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines. Shiokawa, D., Matsushita, T., Kobayashi, T., Matsumoto, Y., Tanuma, S. Genomics (2004) [Pubmed]
  5. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. Rodriguez, A.M., Rodin, D., Nomura, H., Morton, C.C., Weremowicz, S., Schneider, M.C. Genomics (1997) [Pubmed]
  6. Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties. Hammond, M.L. J. Antimicrob. Chemother. (2004) [Pubmed]
  7. Synthesis and antibacterial activity of new 2-substituted penems. II. Nishi, T., Higashi, K., Soga, T., Takemura, M., Sato, M. J. Antibiot. (1994) [Pubmed]
  8. Novel C-2 substituted carbapenem derivatives. Part II. Synthesis and structure-activity relationships of isoxazolin-2-yl, isoxazolidin-2-yl and 2-pyrazolin-2-yl carbapenems generated using 1,3-dipolar cycloaddition chemistry. Burton, G., Clarke, G.J., Douglas, J.D., Eglington, A.J., Frydrych, C.H., Hinks, J.D., Hird, N.W., Hunt, E., Moss, S.F., Naylor, A., Nicholson, N.H., Pearson, M.J. J. Antibiot. (1996) [Pubmed]
  9. Novel C-2 substituted carbapenem derivatives. Part IV. Synthesis and biological activity of five membered heteroaromatic derivatives. Branch, C.L., Burton, G., Clarke, G.J., Coulton, S., Douglas, J.D., Eglington, A.J., Guest, A.W., Hinks, J.D., Hird, N.W., Holland, R.K., Hunt, E., Knott, S.J., Moss, S.F., Naylor, A., Pearson, M.J., Takle, A.K. J. Antibiot. (1998) [Pubmed]
  10. Clearance and tissue distribution of staphylococcal enterotoxin A in the rat and potential use of adsorbents for removal from plasma. Nagaki, M., Hughes, R.D., Keane, H.M., Goka, J., Williams, R. J. Med. Microbiol. (1993) [Pubmed]
  11. Modification of the cysteamine side chain of thienamycin. II. Sato, M., Takemura, M., Atarashi, S., Higashi, K., Fujiwara, H., Nagahara, T., Furukawa, M., Ikeuchi, T., Ozawa, S., Nishizawa, N. J. Antibiot. (1987) [Pubmed]
  12. Recent advances in the chemistry and biology of carbapenem antibiotics. Coulton, S., Hunt, E. Progress in medicinal chemistry. (1996) [Pubmed]
  13. Characterization of two DNase gamma-specific monoclonal antibodies and the in situ detection of DNase gamma in the nuclei of apoptotic rat thymocytes. Shiokawa, D., Tanaka, M., Kimura, T., Hashizume, K., Takasawa, R., Ohyama, H., Fujita, K., Yamada, T., Tanuma, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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