Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Nfil3 - nuclear factor, interleukin 3, regulated

Mus musculus

Synonyms: AV225605, E4 promoter-binding protein 4, E4BP4, E4bp4, Embryo implantation-related NFIL3/E4BP4-like transcription factor, ...

Kuribara, R. et al., Mitsui, S. et al., Nishimura, Y. et al., Chu, C.C. et al., Zhou, D. et al., et al.

Chu, Paul,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nfil3

Using this method, we found that the recently identified human protein adenovirus E4 promoter binding protein (E4BP4) mRNA was induced by Dex in the ID13 cell line [1].

High impact information on Nfil3

Moreover, all PAR proteins activate, whereas E4BP4 suppresses, the transcriptional activity of the reporter gene containing a common binding sequence in transcriptional assays in vitro [2].
An electrophoretic mobility shift assay demonstrated that E4BP4 is not able to dimerize with the PAR proteins, but is able to compete for the same binding sites with them [2].
Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes [3].
Expression of dominant negative forms of calcineurin or nuclear factor of activated T cells (NFAT) inhibited the induction of NFIL3/E4BP4 mRNA by TG [4].
These results suggest that intracellular Ca(2+) plays a critical role in regulating gene expression of NFIL3/E4BP4 by calcineurin/NFAT and CaM kinase signaling in vascular smooth muscle cells [4].

Biological context of Nfil3

The NFIL3 (E4BP4) transcription factor, Bcl-xL, and constitutively active mutants of components in Ras signal transduction pathways have been identified as key regulation proteins affecting murine interleukin-3 (IL-3)-dependent cell survival [3].

Anatomical context of Nfil3

Adenovirus E4 promoter-binding protein/nuclear factor regulated by IL-3 (E4BP4/NFIL3), a transcriptional repressor, is a PTH-induced primary response gene in primary mouse osteoblasts (MOBs) [5].

Regulatory relationships of Nfil3

One unknown gene (designated Fig1 for IL-Four Induced Gene 1) and one gene with homology to the human transcription factor E4BP4 were confirmed by Northern blot analysis to be induced 10-20-fold by IL-4 treatment [6].

Other interactions of Nfil3

Further analysis of the cis-regulatory regions of downregulated genes revealed that transcription suppressors, BCL6 and E4BP4, were probable candidates that mediated the inhibitory effect of NHE1 null mutation [7].

Analytical, diagnostic and therapeutic context of Nfil3

Northern blot analysis showed that Nfil3/E4bp4 is regulated as a "delayed-early" IL-3-responsive gene, requiring de novo protein synthesis [8].

References

Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids. Wallace, A.D., Wheeler, T.T., Young, D.A. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., Okamura, H. Genes Dev. (2001) [Pubmed]
Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. Kuribara, R., Kinoshita, T., Miyajima, A., Shinjyo, T., Yoshihara, T., Inukai, T., Ozawa, K., Look, A.T., Inaba, T. Mol. Cell. Biol. (1999) [Pubmed]
Calcium-dependent activation of nuclear factor regulated by interleukin 3/adenovirus E4 promoter-binding protein gene expression by calcineurin/nuclear factor of activated T cells and calcium/calmodulin-dependent protein kinase signaling. Nishimura, Y., Tanaka, T. J. Biol. Chem. (2001) [Pubmed]
Parathyroid hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic adenosine 3',5'-monophosphate signaling in osteoblasts. Ozkurt, I.C., Pirih, F.Q., Tetradis, S. Endocrinology (2004) [Pubmed]
Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu, C.C., Paul, W.E. Mol. Immunol. (1998) [Pubmed]
Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain. Zhou, D., Xue, J., Gavrialov, O., Haddad, G.G. Physiol. Genomics (2004) [Pubmed]
Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Ikushima, S., Inukai, T., Inaba, T., Nimer, S.D., Cleveland, J.L., Look, A.T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

NFIL3	Bos taurus
NFIL3	Canis lupus familiaris
nfil3	Danio rerio
NFIL3	Gallus gallus
NFIL3	Homo sapiens
NFIL3	Macaca mulatta
NFIL3	Pan troglodytes
Nfil3	Rattus norvegicus
nfil3	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.