Disease relevance of DRG2

• The few trkC+ neurons present late in DRG2 development are not concentrated in the VL portion of the ganglion, the zone where trkC+ neurons are generally found in normal DRG [1].

High impact information on DRG2

• DRG1 and DRG2 comprise a highly conserved subfamily of GTP-binding proteins and are thought to act as critical regulators of cell growth [2].
• The dermaseptin genes Drg2 and Drg1g2 have conserved sequences at both untranslated ends and in the first and second coding exons [3].
• Overexpression of DRG2 suppressed the growth and the aggregation of Jurkat cells but did not induce apoptotic cell death [4].
• Overexpression of DRG2 suppresses the growth of Jurkat T cells but does not induce apoptosis [4].
• We used cDNA microarray analysis to examine the global changes in gene expression induced by an overexpression of DRG2 [4].

Biological context of DRG2

• Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval [5].
• To investigate the effect of the expression of DRG2 on cell growth, we constructed a human Jurkat-T-cell line that overexpresses DRG2 [4].
• Cell cycle distribution analysis revealed an increased accumulation of G(2)/M phase cells in Jurkat-LNCX2-DRG2 cells, indicating a retardation of cell-cycle progression [6].
• The significance of this down-regulation and the cellular role of DRG2 has not been understood in the past [6].
• The amino-acid sequence of Cn12 resembles the beta scorpion toxin class, although patch-clamp experiments showed the induction of supplementary slow inactivation of Na(+) channels in F-11 cells (mouse neuroblastoma N18TG-2 x rat DRG2), which means that it behaves more like an alpha scorpion toxin [7].

Anatomical context of DRG2

• DRG2, a member of the DRG subfamily in the GTP-binding protein superfamily, was identified as a repressed gene product in fibroblasts transformed by SV40 [6].
• In this study, we compared several aspects of neural differentiation between the longest-lived Frorieps' ganglia, DRG2, and normal trunk DRG in chick embryos [8].
• Somite-grafting experiments reveal that the increased proportion of Isl-1(+) in DRG2 is due to the special microenvironment of the cranial somites [8].

Associations of DRG2 with chemical compounds

• In addition, an overexpression of DRG2 reduced the sensitivity of Jurkat cells to the mitotic poison nocodazole [6].

Regulatory relationships of DRG2

• Islet-1 is expressed in a higher proportion of cells in DRG2 than DRG5, suggesting that cells in DRG2 differentiate more rapidly into neurons than in normal DRG [8].

Other interactions of DRG2

• In contrast to Islet-1, the Hu antigen is expressed in a slightly lower proportion of cells in DRG2 at St [8].

Analytical, diagnostic and therapeutic context of DRG2

• Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13-->p12 by in situ hybridization [9].

References