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Gene Review

Fabp5  -  fatty acid binding protein 5, epidermal

Mus musculus

Synonyms: E-FABP, Epidermal-type fatty acid-binding protein, Fabpe, Fabpe E-FABP, Fatty acid-binding protein 5, ...
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Disease relevance of Fabp5


High impact information on Fabp5

  • However, in the presence of 10 microm oleate, A-FABP and E-FABP each bound to HSL with high affinity (Kd of 0.5 and 3 nM, respectively) in a approximately 1:1 molar stoichiometry, whereas liver FABP and intestinal FABP did not exhibit any association [5].
  • Adipocytes isolated from mal1-deficient mice also exhibited enhanced insulin-stimulated glucose transport capacity [1].
  • Hence, our results demonstrate that mal1 modulates adipose tissue function and contributes to systemic glucose metabolism and constitutes a potential therapeutic target in insulin resistance [1].
  • In contrast, mice expressing high levels of mal1 in adipose tissue display reduced systemic insulin sensitivity [1].
  • Here, we report the generation of mice with targeted null mutations in the mal1 gene as well as transgenic mice overexpressing mal1 from the aP2 promoter/enhancer to address the role of this FABP in metabolic regulation in the presence or absence of obesity [1].

Biological context of Fabp5


Anatomical context of Fabp5

  • We present evidence that endogenous ACBP, ALBP, and KLBP not only localize to the cytoplasm but also exhibit a prominent nuclear localization in 3T3-L1 adipocytes [8].
  • Evaluation of retinal pigment epithelial cell extracts derived from E-FABP null mice by two-dimensional gel electrophoresis using anti-4-HNE antibodies revealed increased modification in the null cells relative to those from wild type cells [9].
  • It appears that the small amount of E-FABP expressed in MCF7 cells fulfils the need of the cells for a cytosolic fatty acid carrier under culture conditions and that even high concentrations of another FABP do only slightly increase the uptake due to limitations of fatty acid transport through the plasma membrane or of metabolism [10].
  • The possible natures of these cells immunoreactive for E-FABP are discussed in view of a subpopulation of endothelial cells or the dendritic cells of antigen-presenting property [11].
  • On the other hand, epidermal-type fatty acid binding protein (E-FABP) is localized in two discrete cells in the adrenal gland: the one is a subpopulation of intra-adrenal macrophages which are intensely immunoreactive for F4/80, a marker of macrophages, and are rich in pleomorphic lysosomes [11].

Associations of Fabp5 with chemical compounds


Other interactions of Fabp5

  • This indicated that E-FABP and/or H-FABP are involved in the mediation of DPPC synthesis in wt TII cells [13].
  • We tested the hypothesis that combined aP2 and mal1 deficiency would produce synergistic effects on metabolism and reduce atherosclerosis in apolipoprotein E-deficient (apoE-/-) mice [14].
  • In vitro translation of mal1 RNA yielded a polypeptide of the predicted size of 15 kDa that was immunoprecipitable with an anti-rat liver fatty acid-binding protein antiserum [2].
  • These results indicate that E-FABP is a molecular target for 4-HNE modification and the hypothesis that E-FABP functions as an antioxidant protein by scavenging reactive lipids through covalent modification of Cys-120 [9].
  • The non-tumor-promoting hyperplastic agent, ethylphenyl propiolate (EPP), applied to the skin at a hyperplastic dose level did not enhance the expression of the mal 4 or transin sequences in the epidermis and had only a slight enhancing effect on the levels of mal 1 and mal 2 transcripts in the epidermis [15].

Analytical, diagnostic and therapeutic context of Fabp5

  • RT-PCR on primary adipocyte RNA demonstrated expression of this KLBP gene by amplification of intron 3 from the primary transcript [6].
  • Based on the sequence analysis and antigenic properties of mal1, we conclude that it encodes a novel member of the lipid-binding protein family [2].
  • In Northern blot analysis for other FABPs, the gene expression of heart (H-)-type FABP is specifically elevated in the liver of neonatal heterozygous and homozygous mice, suggesting the functional compensation of H-FABP for E-FABP deficiency during their development [16].
  • The localization of epidermal-type fatty acid binding protein (E-FABP) in the mature mouse ovary was examined by immuno-light and electron microscopy [17].


  1. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Maeda, K., Uysal, K.T., Makowski, L., Görgün, C.Z., Atsumi, G., Parker, R.A., Brüning, J., Hertzel, A.V., Bernlohr, D.A., Hotamisligil, G.S. Diabetes (2003) [Pubmed]
  2. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. Krieg, P., Feil, S., Fürstenberger, G., Bowden, G.T. J. Biol. Chem. (1993) [Pubmed]
  3. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Cao, H., Maeda, K., Gorgun, C.Z., Kim, H.J., Park, S.Y., Shulman, G.I., Kim, J.K., Hotamisligil, G.S. Diabetes (2006) [Pubmed]
  4. Adenovirus-mediated gene transfer in primary murine adipocytes. Hertzel, A.V., Sanders, M.A., Bernlohr, D.A. J. Lipid Res. (2000) [Pubmed]
  5. Fatty acid-binding protein-hormone-sensitive lipase interaction. Fatty acid dependence on binding. Jenkins-Kruchten, A.E., Bennaars-Eiden, A., Ross, J.R., Shen, W.J., Kraemer, F.B., Bernlohr, D.A. J. Biol. Chem. (2003) [Pubmed]
  6. Cloning and chromosomal location of the murine keratinocyte lipid-binding protein gene. Hertzel, A.V., Bernlohr, D.A. Gene (1998) [Pubmed]
  7. Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products. Zimmer, J.S., Dyckes, D.F., Bernlohr, D.A., Murphy, R.C. J. Lipid Res. (2004) [Pubmed]
  8. Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm. Helledie, T., Antonius, M., Sorensen, R.V., Hertzel, A.V., Bernlohr, D.A., Kølvraa, S., Kristiansen, K., Mandrup, S. J. Lipid Res. (2000) [Pubmed]
  9. Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo. Evidence for a role in antioxidant biology. Bennaars-Eiden, A., Higgins, L., Hertzel, A.V., Kapphahn, R.J., Ferrington, D.A., Bernlohr, D.A. J. Biol. Chem. (2002) [Pubmed]
  10. Fatty acid metabolism in human breast cancer cells (MCF7) transfected with heart-type fatty acid binding protein. Buhlmann, C., Börchers, T., Pollak, M., Spener, F. Mol. Cell. Biochem. (1999) [Pubmed]
  11. Differential localization of brain-type and epidermal-type fatty acid binding proteins in the adrenal gland of mice. Yun, X., Nourani, M.R., Abdelwahab, S.A., Kitanaka, N., Owada, Y., Spener, F., Iwasa, H., Takahashi, A., Kondo, H. Tohoku J. Exp. Med. (2004) [Pubmed]
  12. Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes. Simpson, M.A., LiCata, V.J., Ribarik Coe, N., Bernlohr, D.A. Mol. Cell. Biochem. (1999) [Pubmed]
  13. Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Guthmann, F., Schachtrup, C., Tölle, A., Wissel, H., Binas, B., Kondo, H., Owada, Y., Spener, F., Rüstow, B. Biochim. Biophys. Acta (2004) [Pubmed]
  14. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Boord, J.B., Maeda, K., Makowski, L., Babaev, V.R., Fazio, S., Linton, M.F., Hotamisligil, G.S. Circulation (2004) [Pubmed]
  15. Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis. Krieg, P., Finch, J., Füstenberger, G., Melber, K., Matrisian, L.M., Bowden, G.T. Carcinogenesis (1988) [Pubmed]
  16. Analysis on the phenotype of E-FABP-gene knockout mice. Owada, Y., Suzuki, I., Noda, T., Kondo, H. Mol. Cell. Biochem. (2002) [Pubmed]
  17. Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice. Nourani, M.R., Owada, Y., Kitanaka, N., Abdelwahab, S.A., Iwasa, H., Sakagami, H., Spener, F., Kondo, H. J. Mol. Histol. (2005) [Pubmed]
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