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Gene Review

EMP2  -  epithelial membrane protein 2

Homo sapiens

Synonyms: EMP-2, Epithelial membrane protein 2, NPHS10, Protein XMP, XMP
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Disease relevance of EMP2


High impact information on EMP2

  • In one strain of parasite there was a significant difference in relative mobility of the 125I-surface-labeled Pf EMP 1 and the biosynthetically labeled Pf EMP 2, further distinguishing these proteins [5].
  • The mAbs did not react with the surface of intact infected erythrocytes, nor was Pf EMP 2 accessible to exogenous proteases or lactoperoxidase-catalyzed radioiodination of intact cells [5].
  • Transport of an Mr approximately 300,000 Plasmodium falciparum protein (Pf EMP 2) from the intraerythrocytic asexual parasite to the cytoplasmic face of the host cell membrane [5].
  • Despite the recessive emp2 phenotype, steady state levels of emp2 transcripts were abundant in mutant kernels, and the predicted coding region was unaffected [6].
  • Furthermore, the developmental retardation of emp2 mutant kernels before the HSR suggests an additional role for EMP2 during embryo development distinct from the HSR [6].

Biological context of EMP2


Anatomical context of EMP2


Associations of EMP2 with chemical compounds

  • The interaction between EMP-2 and P2X(7) was confirmed biochemically by co-immunoprecipitation, co-purification, and glutathione S-transferase pull-down assays, and this interaction was entirely dependent on the C-terminal domain of P2X(7) [7].
  • In other cell types, EMP2 controls delivery of certain classes of proteins to the cell surface, including various integrin isoforms (a class of receptors implicated in endometrial-blastocyst interaction) [10].

Other interactions of EMP2


Analytical, diagnostic and therapeutic context of EMP2

  • A multivariate analysis of disease-free survival demonstrated independent, negative prognostic significance for EMP2 expression, high stage, and high-risk histologic subtypes [2].
  • Cloning and sequence analyses revealed that the emp2 gene encoded a predicted protein with high similarity to HEAT SHOCK BINDING PROTEIN1, which was first described in animals as a negative regulator of the HSR. emp2 is a loss-of-function mutation of an HSR-negative regulator in plants [6].


  1. Clonal mosaic analysis of EMPTY PERICARP2 reveals nonredundant functions of the duplicated HEAT SHOCK FACTOR BINDING PROTEINs during maize shoot development. Fu, S., Scanlon, M.J. Genetics (2004) [Pubmed]
  2. Expression of epithelial membrane protein-2 is associated with endometrial adenocarcinoma of unfavorable outcome. Wadehra, M., Natarajan, S., Seligson, D.B., Williams, C.J., Hummer, A.J., Hedvat, C., Braun, J., Soslow, R.A. Cancer (2006) [Pubmed]
  3. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Shimazaki, K., Lepin, E.J., Wei, B., Nagy, A.K., Coulam, C.P., Mareninov, S., Fu, M., Wu, A.M., Marks, J.D., Braun, J., Gordon, L.K., Wadehra, M. Clin. Cancer Res. (2008) [Pubmed]
  4. Epithelial membrane protein-2 is a novel therapeutic target in ovarian cancer. Fu, M., Maresh, E.L., Soslow, R.A., Alavi, M., Mah, V., Zhou, Q., Iasonos, A., Goodglick, L., Gordon, L.K., Braun, J., Wadehra, M. Clin. Cancer Res. (2010) [Pubmed]
  5. Transport of an Mr approximately 300,000 Plasmodium falciparum protein (Pf EMP 2) from the intraerythrocytic asexual parasite to the cytoplasmic face of the host cell membrane. Howard, R.J., Lyon, J.A., Uni, S., Saul, A.J., Aley, S.B., Klotz, F., Panton, L.J., Sherwood, J.A., Marsh, K., Aikawa, M. J. Cell Biol. (1987) [Pubmed]
  6. Empty pericarp2 encodes a negative regulator of the heat shock response and is required for maize embryogenesis. Fu, S., Meeley, R., Scanlon, M.J. Plant Cell (2002) [Pubmed]
  7. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. Wilson, H.L., Wilson, S.A., Surprenant, A., North, R.A. J. Biol. Chem. (2002) [Pubmed]
  8. Mapping of Charcot-Marie-Tooth disease type 1C to chromosome 16p identifies a novel locus for demyelinating neuropathies. Street, V.A., Goldy, J.D., Golden, A.S., Tempel, B.L., Bird, T.D., Chance, P.F. Am. J. Hum. Genet. (2002) [Pubmed]
  9. The maize heat shock factor-binding protein paralogs EMP2 and HSBP2 interact non-redundantly with specific heat shock factors. Fu, S., Rogowsky, P., Nover, L., Scanlon, M.J. Planta (2006) [Pubmed]
  10. Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. Wadehra, M., Forbes, A., Pushkarna, N., Goodglick, L., Gordon, L.K., Williams, C.J., Braun, J. Dev. Biol. (2005) [Pubmed]
  11. Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. Wadehra, M., Sulur, G.G., Braun, J., Gordon, L.K., Goodglick, L. Exp. Mol. Pathol. (2003) [Pubmed]
  12. Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family. Taylor, V., Suter, U. Gene (1996) [Pubmed]
  13. Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes. Howard, R.J., Barnwell, J.W., Rock, E.P., Neequaye, J., Ofori-Adjei, D., Maloy, W.L., Lyon, J.A., Saul, A. Mol. Biochem. Parasitol. (1988) [Pubmed]
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