The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Adcy10  -  adenylate cyclase 10

Mus musculus

Synonyms: 4930431D04Rik, 4931412F17, Adenylate cyclase type 10, Germ cell soluble adenylyl cyclase, Sac, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sacy


High impact information on Sacy


Biological context of Sacy

  • The truncated sAC transcript lacks exon 11 with a premature termination of the open reading frame after the catalytic domain [3].
  • Elevated levels of sAC mRNA are first observed in pachytene spermatocytes and expression increases through spermiogenesis [4].
  • The accumulation of high levels of message in round spermatids suggests sAC protein plays an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction [4].
  • This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC [5].
  • The immotility phenotype of the sNHE null spermatozoa appears to result from an intimate association of sNHE and the atypical adenylyl cyclase (sAC), while a failure of calcium entry requiring an apparent CatSper1 and -2 heteromeric ion channel correlates with a hyperactivation defect in these null animals [6].

Anatomical context of Sacy


Associations of Sacy with chemical compounds


Other interactions of Sacy


Analytical, diagnostic and therapeutic context of Sacy


  1. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Esposito, G., Jaiswal, B.S., Xie, F., Krajnc-Franken, M.A., Robben, T.J., Strik, A.M., Kuil, C., Philipsen, R.L., van Duin, M., Conti, M., Gossen, J.A., Jaiswal, B.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Anion exchanger 2 is essential for spermiogenesis in mice. Medina, J.F., Recalde, S., Prieto, J., Lecanda, J., Saez, E., Funk, C.D., Vecino, P., van Roon, M.A., Ottenhoff, R., Bosma, P.J., Bakker, C.T., Elferink, R.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. Jaiswal, B.S., Conti, M. J. Biol. Chem. (2001) [Pubmed]
  4. Specific expression of soluble adenylyl cyclase in male germ cells. Sinclair, M.L., Wang, X.Y., Mattia, M., Conti, M., Buck, J., Wolgemuth, D.J., Levin, L.R. Mol. Reprod. Dev. (2000) [Pubmed]
  5. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Hess, K.C., Jones, B.H., Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Miyamoto, C., Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R., Williams, C.J., Buck, J., Moss, S.B. Dev. Cell (2005) [Pubmed]
  6. Insights into sperm cell motility signaling through sNHE and the CatSpers. Quill, T.A., Wang, D., Garbers, D.L. Mol. Cell. Endocrinol. (2006) [Pubmed]
  7. Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Xie, F., Garcia, M.A., Carlson, A.E., Schuh, S.M., Babcock, D.F., Jaiswal, B.S., Gossen, J.A., Esposito, G., van Duin, M., Conti, M. Dev. Biol. (2006) [Pubmed]
  8. A soluble adenylyl cyclase from sea urchin spermatozoa. Nomura, M., Beltrán, C., Darszon, A., Vacquier, V.D. Gene (2005) [Pubmed]
  9. Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa. Baxendale, R.W., Fraser, L.R. Mol. Reprod. Dev. (2003) [Pubmed]
WikiGenes - Universities