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Gene Review

Zfp1  -  zinc finger protein 1

Mus musculus

Synonyms: Fnp-1, Protein mKR1, Zfp-1, Zinc finger protein 1, mkr-1
 
 
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Disease relevance of Zfp1

 

High impact information on Zfp1

  • Zinc finger-reactive compounds may offer an anti-HIV strategy that restricts drug-resistance development [2].
  • The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells [3].
  • Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development [4].
  • Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions [5].
  • Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products [6].
 

Biological context of Zfp1

 

Anatomical context of Zfp1

 

Associations of Zfp1 with chemical compounds

  • NAC1 is a cocaine-regulated POZ/BTB (Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex) protein [12].
 

Other interactions of Zfp1

References

  1. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Segal, D.J., Dreier, B., Beerli, R.R., Barbas, C.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS. Rice, W.G., Supko, J.G., Malspeis, L., Buckheit, R.W., Clanton, D., Bu, M., Graham, L., Schaeffer, C.A., Turpin, J.A., Domagala, J., Gogliotti, R., Bader, J.P., Halliday, S.M., Coren, L., Sowder, R.C., Arthur, L.O., Henderson, L.E. Science (1995) [Pubmed]
  3. The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Gierl, M.S., Karoulias, N., Wende, H., Strehle, M., Birchmeier, C. Genes Dev. (2006) [Pubmed]
  4. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. Sun, L., Liu, A., Georgopoulos, K. EMBO J. (1996) [Pubmed]
  5. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Hirata, T., Nakazawa, M., Muraoka, O., Nakayama, R., Suda, Y., Hibi, M. Development (2006) [Pubmed]
  6. Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products. Kazanietz, M.G., Bustelo, X.R., Barbacid, M., Kolch, W., Mischak, H., Wong, G., Pettit, G.R., Bruns, J.D., Blumberg, P.M. J. Biol. Chem. (1994) [Pubmed]
  7. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Chowdhury, K., Dietrich, S., Balling, R., Guenet, J.L., Gruss, P. Nucleic Acids Res. (1989) [Pubmed]
  8. Zinc finger protein genes in the mouse genome. Ashworth, A., Denny, P. Mamm. Genome (1991) [Pubmed]
  9. Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia. Hentges, K.E., Weiser, K.C., Schountz, T., Woodward, L.S., Morse, H.C., Justice, M.J. Oncogene (2005) [Pubmed]
  10. Ciz1 promotes mammalian DNA replication. Coverley, D., Marr, J., Ainscough, J. J. Cell. Sci. (2005) [Pubmed]
  11. Zinc finger proteins in the peripheral nerve of adult normal and Trembler mice. Labatut-Cazabat, I., Garbay, B., Faveraux, A., Hilmi, S., Vital, C., Cassagne, C., Petry, K.G. J. Peripher. Nerv. Syst. (2001) [Pubmed]
  12. The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. Korutla, L., Wang, P.J., Mackler, S.A. J. Neurochem. (2005) [Pubmed]
  13. Zinc finger transcription factors as molecular targets for nitric oxide-mediated immunosuppression: inhibition of IL-2 gene expression in murine lymphocytes. Berendji, D., Kolb-Bachofen, V., Zipfel, P.F., Skerka, C., Carlberg, C., Kröncke, K.D. Mol. Med. (1999) [Pubmed]
 
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