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Gene Review

Zyx  -  zyxin

Mus musculus

Synonyms: 9530098H06Rik, R75157, Zyxin
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Disease relevance of Zyx

  • Zyxin is the founding member of a family of proteins that also includes the lipoma preferred partner (LPP) and thyroid receptor-interacting protein 6 (TRIP6) [1].

High impact information on Zyx


Biological context of Zyx

  • To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene was deleted by homologous recombination [2].
  • Western blot analysis indicates that there is no detectable upregulation of either LPP or TRIP6 expression in tissues derived from zyxin-null mice [1].
  • Zyxin is an evolutionarily conserved protein that is concentrated at sites of cell adhesion, where it associates with members of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family of cytoskeletal regulators and is postulated to play a role in cytoskeletal dynamics and signaling [1].

Associations of Zyx with chemical compounds

  • Ena-VASP proteins share an identical domain organization with an NH2-terminal Ena VASP homology (EVH1) domain, which mediates the binding of these proteins to FPPPP-motif containing partners such as zyxin and vinculin [4].

Other interactions of Zyx


  1. Targeted disruption of the murine zyxin gene. Hoffman, L.M., Nix, D.A., Benson, B., Boot-Hanford, R., Gustafsson, E., Jamora, C., Menzies, A.S., Goh, K.L., Jensen, C.C., Gertler, F.B., Fuchs, E., Fässler, R., Beckerle, M.C. Mol. Cell. Biol. (2003) [Pubmed]
  2. Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. Hoffman, L.M., Jensen, C.C., Kloeker, S., Wang, C.L., Yoshigi, M., Beckerle, M.C. J. Cell Biol. (2006) [Pubmed]
  3. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Lai, Y.J., Chen, C.S., Lin, W.C., Lin, F.T. Mol. Cell. Biol. (2005) [Pubmed]
  4. Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. Eigenthaler, M., Engelhardt, S., Schinke, B., Kobsar, A., Schmitteckert, E., Gambaryan, S., Engelhardt, C.M., Krenn, V., Eliava, M., Jarchau, T., Lohse, M.J., Walter, U., Hein, L. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  5. Identification of essential genes in cultured mammalian cells using small interfering RNAs. Harborth, J., Elbashir, S.M., Bechert, K., Tuschl, T., Weber, K. J. Cell. Sci. (2001) [Pubmed]
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