Gene Review:
Lmna - lamin A
Mus musculus
Synonyms:
Dhe, Lmn1, Prelamin-A/C, lamin A/C
- Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. Nikolova, V., Leimena, C., McMahon, A.C., Tan, J.C., Chandar, S., Jogia, D., Kesteven, S.H., Michalicek, J., Otway, R., Verheyen, F., Rainer, S., Stewart, C.L., Martin, D., Feneley, M.P., Fatkin, D. J. Clin. Invest. (2004)
- Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Fong, L.G., Ng, J.K., Meta, M., Coté, N., Yang, S.H., Stewart, C.L., Sullivan, T., Burghardt, A., Majumdar, S., Reue, K., Bergo, M.O., Young, S.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Hutchinson-Gilford progeria syndrome. Pollex, R.L., Hegele, R.A. Clin. Genet. (2004)
- Characterization of adiposity and metabolism in Lmna-deficient mice. Cutler, D.A., Sullivan, T., Marcus-Samuels, B., Stewart, C.L., Reitman, M.L. Biochem. Biophys. Res. Commun. (2002)
- Prelamin A and lamin A appear to be dispensable in the nuclear lamina. Fong, L.G., Ng, J.K., Lammerding, J., Vickers, T.A., Meta, M., Coté, N., Gavino, B., Qiao, X., Chang, S.Y., Young, S.R., Yang, S.H., Stewart, C.L., Lee, R.T., Bennett, C.F., Bergo, M.O., Young, S.G. J. Clin. Invest. (2006)
- Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Pendás, A.M., Zhou, Z., Cadiñanos, J., Freije, J.M., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., López-Otín, C. Nat. Genet. (2002)
- Genomic instability in laminopathy-based premature aging. Liu, B., Wang, J., Chan, K.M., Tjia, W.M., Deng, W., Guan, X., Huang, J.D., Li, K.M., Chau, P.Y., Chen, D.J., Pei, D., Pendas, A.M., Cadiñanos, J., López-Otín, C., Tse, H.F., Hutchison, C., Chen, J., Cao, Y., Cheah, K.S., Tryggvason, K., Zhou, Z. Nat. Med. (2005)
- A progeroid syndrome in mice is caused by defects in A-type lamins. Mounkes, L.C., Kozlov, S., Hernandez, L., Sullivan, T., Stewart, C.L. Nature (2003)
- Expression of prelamin A but not mature lamin A confers sensitivity of DNA biosynthesis to lovastatin on F9 teratocarcinoma cells. Sinensky, M., McLain, T., Fantle, K. J. Cell. Sci. (1994)
- Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Frock, R.L., Kudlow, B.A., Evans, A.M., Jameson, S.A., Hauschka, S.D., Kennedy, B.K. Genes Dev. (2006)
- A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Johnson, B.R., Nitta, R.T., Frock, R.L., Mounkes, L., Barbie, D.A., Stewart, C.L., Harlow, E., Kennedy, B.K. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. Nitta, R.T., Jameson, S.A., Kudlow, B.A., Conlan, L.A., Kennedy, B.K. Mol. Cell. Biol. (2006)
- Disruption of spermatogenesis in mice lacking A-type lamins. Alsheimer, M., Liebe, B., Sewell, L., Stewart, C.L., Scherthan, H., Benavente, R. J. Cell. Sci. (2004)
- Good news in the nuclear envelope: loss of lamin A might be a gain. Scaffidi, P., Misteli, T. J. Clin. Invest. (2006)
- c-Jun and Sp1 family are critical for retinoic acid induction of the lamin A/C retinoic acid-responsive element. Okumura, K., Hosoe, Y., Nakajima, N. Biochem. Biophys. Res. Commun. (2004)
- Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. Caron, M., Auclair, M., Sterlingot, H., Kornprobst, M., Capeau, J. AIDS (2003)
- Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy. Grattan, M.J., Kondo, C., Thurston, J., Alakija, P., Burke, B.J., Stewart, C., Syme, D., Giles, W.R. Novartis Found. Symp. (2005)
- Expression of a mutant lamin A that causes Emery-Dreifuss muscular dystrophy inhibits in vitro differentiation of C2C12 myoblasts. Favreau, C., Higuet, D., Courvalin, J.C., Buendia, B. Mol. Cell. Biol. (2004)
- Activation of caspases in pig kidney cells infected with wild-type and CrmA/SPI-2 mutants of cowpox and rabbitpox viruses. Macen, J., Takahashi, A., Moon, K.B., Nathaniel, R., Turner, P.C., Moyer, R.W. J. Virol. (1998)
- Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. Lammerding, J., Schulze, P.C., Takahashi, T., Kozlov, S., Sullivan, T., Kamm, R.D., Stewart, C.L., Lee, R.T. J. Clin. Invest. (2004)
- Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy. Favreau, C., Dubosclard, E., Ostlund, C., Vigouroux, C., Capeau, J., Wehnert, M., Higuet, D., Worman, H.J., Courvalin, J.C., Buendia, B. Exp. Cell Res. (2003)
- Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins. Ostlund, C., Sullivan, T., Stewart, C.L., Worman, H.J. Biochemistry (2006)
- A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Lloyd, D.J., Trembath, R.C., Shackleton, S. Hum. Mol. Genet. (2002)
- Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study. Röber, R.A., Weber, K., Osborn, M. Development (1989)
- Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy. Ostlund, C., Bonne, G., Schwartz, K., Worman, H.J. J. Cell. Sci. (2001)
- Age-related changes in lamin A/C expression in the osteoarticular system: laminopathies as a potential new aging mechanism. Duque, G., Rivas, D. Mech. Ageing Dev. (2006)