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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lipoma


High impact information on Lipoma

  • Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains [6].
  • Metastatic hibernomas in transgenic mice expressing an alpha-amylase-SV40 T antigen hybrid gene [7].
  • No such hibernoma occurred in P2-TAg transgenic mice [8].
  • Similar truncations of murine Hmga2 in transgenic mice result in somatic overgrowth and, in particular, increased abundance of fat and lipomas, features strikingly similar to those observed in the child [9].
  • To determine whether other syndromes characterized by overgrowth and lipomas are part of the PTEN syndrome spectrum, we ascertained six individuals with overgrowth and lipomas but who did not meet the diagnostic criteria for CS or BRR [10].

Chemical compound and disease context of Lipoma


Biological context of Lipoma


Anatomical context of Lipoma


Gene context of Lipoma

  • Additionally, the presence of lipomas was correlated with the presence of PTEN mutation in BRR patients ( P = 0.028) [26].
  • All lipomas were mdm2-negative. cdk4 overexpression was present in 100% of ALTs [27].
  • Rearrangements of the HMGA2 gene have been frequently detected in human benign tumors of mesenchymal origin including lipomas [28].
  • These results suggest a critical role played by HMGA1 rearrangements in the generation of human lipomas [19].
  • LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family [29].

Analytical, diagnostic and therapeutic context of Lipoma


  1. Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas. Vortmeyer, A.O., Böni, R., Pak, E., Pack, S., Zhuang, Z. J. Natl. Cancer Inst. (1998) [Pubmed]
  2. Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function. Hunter, D.S., Klotzbücher, M., Kugoh, H., Cai, S.L., Mullen, J.P., Manfioletti, G., Fuhrman, U., Walker, C.L. Cancer Res. (2002) [Pubmed]
  3. Myxoid liposarcoma with t(12;16) (q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12. Paulien, S., Turc-Carel, C., Dal Cin, P., Jani-Sait, S., Sreekantaiah, C., Leong, S.P., Vogelstein, B., Kinzler, K.W., Sandberg, A.A., Gemmill, R.M. Cancer Res. (1990) [Pubmed]
  4. Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations. Tallini, G., Dal Cin, P., Rhoden, K.J., Chiapetta, G., Manfioletti, G., Giancotti, V., Fusco, A., Van den Berghe, H., Sciot, R. Am. J. Pathol. (1997) [Pubmed]
  5. Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Wiechen, K., Sers, C., Agoulnik, A., Arlt, K., Dietel, M., Schlag, P.M., Schneider, U. Am. J. Pathol. (2001) [Pubmed]
  6. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Ashar, H.R., Fejzo, M.S., Tkachenko, A., Zhou, X., Fletcher, J.A., Weremowicz, S., Morton, C.C., Chada, K. Cell (1995) [Pubmed]
  7. Metastatic hibernomas in transgenic mice expressing an alpha-amylase-SV40 T antigen hybrid gene. Fox, N., Crooke, R., Hwang, L.H., Schibler, U., Knowles, B.B., Solter, D. Science (1989) [Pubmed]
  8. Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action. Zennaro, M.C., Le Menuet, D., Viengchareun, S., Walker, F., Ricquier, D., Lombès, M. J. Clin. Invest. (1998) [Pubmed]
  9. Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas. Ligon, A.H., Moore, S.D., Parisi, M.A., Mealiffe, M.E., Harris, D.J., Ferguson, H.L., Quade, B.J., Morton, C.C. Am. J. Hum. Genet. (2005) [Pubmed]
  10. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Zhou, X.P., Marsh, D.J., Hampel, H., Mulliken, J.B., Gimm, O., Eng, C. Hum. Mol. Genet. (2000) [Pubmed]
  11. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. Blask, D.E., Sauer, L.A., Dauchy, R.T., Holowachuk, E.W., Ruhoff, M.S., Kopff, H.S. Cancer Res. (1999) [Pubmed]
  12. Development of multiple lipomas during treatment with rosiglitazone in a patient with HIV-associated lipoatrophy. Mafong, D.D., Lee, G.A., Yu, S., Tien, P., Mauro, T., Grunfeld, C. AIDS (2004) [Pubmed]
  13. Multiple symmetric lipomatosis (Launois-Bensaude syndrome) - adipose tissue insensitivity to cyclic AMP. Desai, K.S., Zinman, B., Steiner, G. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  14. Growth of intramedullary lipoma in a renal transplant recipient. Agraharkar, A., McGillicuddy, G., Ahuja, T., Agraharkar, M. Transplantation (2000) [Pubmed]
  15. Fatty acid composition of phospholipids and neutral lipids and lipid peroxidation in human breast cancer and lipoma tissue. Hietanen, E., Punnonen, K., Punnonen, R., Auvinen, O. Carcinogenesis (1986) [Pubmed]
  16. Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3. Mrózek, K., Karakousis, C.P., Bloomfield, C.D. Cancer Res. (1993) [Pubmed]
  17. Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis. Pannett, A.A., Thakker, R.V. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  18. MDM2 gene amplification correlates with ring chromosome in soft tissue tumors. Nilbert, M., Rydholm, A., Willén, H., Mitelman, F., Mandahl, N. Genes Chromosomes Cancer (1994) [Pubmed]
  19. A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas. Pierantoni, G.M., Battista, S., Pentimalli, F., Fedele, M., Visone, R., Federico, A., Santoro, M., Viglietto, G., Fusco, A. Carcinogenesis (2003) [Pubmed]
  20. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Petit, M.M., Schoenmakers, E.F., Huysmans, C., Geurts, J.M., Mandahl, N., Van de Ven, W.J. Genomics (1999) [Pubmed]
  21. Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis. Tkachenko, A., Ashar, H.R., Meloni, A.M., Sandberg, A.A., Chada, K.K. Cancer Res. (1997) [Pubmed]
  22. Lipomas of the corpus callosum and epilepsy. Gastaut, H., Regis, H., Gastaut, J.L., Yermenos, E., Low, M.D. Neurology (1980) [Pubmed]
  23. Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva. Nucci, M.R., Weremowicz, S., Neskey, D.M., Sornberger, K., Tallini, G., Morton, C.C., Quade, B.J. Genes Chromosomes Cancer (2001) [Pubmed]
  24. Calretinin expression in tumors of adipose tissue. Cates, J.M., Coffing, B.N., Harris, B.T., Black, C.C. Hum. Pathol. (2006) [Pubmed]
  25. Distribution of basement membrane components in normal adipose tissue and in benign and malignant tumors of lipomatous origin. Haraida, S., Nerlich, A.G., Wiest, I., Schleicher, E., Löhrs, U. Mod. Pathol. (1996) [Pubmed]
  26. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Marsh, D.J., Kum, J.B., Lunetta, K.L., Bennett, M.J., Gorlin, R.J., Ahmed, S.F., Bodurtha, J., Crowe, C., Curtis, M.A., Dasouki, M., Dunn, T., Feit, H., Geraghty, M.T., Graham, J.M., Hodgson, S.V., Hunter, A., Korf, B.R., Manchester, D., Miesfeldt, S., Murday, V.A., Nathanson, K.L., Parisi, M., Pober, B., Romano, C., Eng, C. Hum. Mol. Genet. (1999) [Pubmed]
  27. Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. Dei Tos, A.P., Doglioni, C., Piccinin, S., Sciot, R., Furlanetto, A., Boiocchi, M., Dal Cin, P., Maestro, R., Fletcher, C.D., Tallini, G. J. Pathol. (2000) [Pubmed]
  28. Role of the high mobility group A proteins in human lipomas. Fedele, M., Battista, S., Manfioletti, G., Croce, C.M., Giancotti, V., Fusco, A. Carcinogenesis (2001) [Pubmed]
  29. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Petit, M.M., Mols, R., Schoenmakers, E.F., Mandahl, N., Van de Ven, W.J. Genomics (1996) [Pubmed]
  30. Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms. Pilotti, S., Della Torre, G., Lavarino, C., Di Palma, S., Sozzi, G., Minoletti, F., Rao, S., Pasquini, G., Azzarelli, A., Rilke, F., Pierotti, M.A. J. Pathol. (1997) [Pubmed]
  31. Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. Kubo, T., Matsui, Y., Goto, T., Yukata, K., Yasui, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  32. Hibernomas show intense accumulation of FDG positron emission tomography. Tsuchiya, T., Osanai, T., Ishikawa, A., Kato, N., Watanabe, Y., Ogino, T. Journal of computer assisted tomography. (2006) [Pubmed]
  33. Ultrastructure of lipoma. Kim, Y.H., Reiner, L. Cancer (1982) [Pubmed]
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