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Gene Review

Sgcd  -  sarcoglycan, delta (dystrophin-associated...

Mus musculus

Synonyms: 35 kDa dystrophin-associated glycoprotein, 35DAG, 35kDa, Delta-SG, Delta-sarcoglycan, ...
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Disease relevance of Sgcd


High impact information on Sgcd


Chemical compound and disease context of Sgcd


Biological context of Sgcd


Anatomical context of Sgcd

  • In skeletal and cardiac muscle, sarcoglycans exist as a complex of four transmembrane proteins (alpha-, beta-, gamma-, and delta-SG) [11].
  • We found that beta-SG appears to play an initiating role and its association with delta-SG is essential for the proper localization of the sarcoglycan complex to the cell membrane [11].
  • This observation suggests that the epsilon-, beta- and delta-SG molecules form a complex behaving as a single unit similar to the SG complex in muscle cells [12].
  • Analysis of the properties of myotubes prepared from delta-sarcoglycan-deficient BIO14.6 hamsters revealed that GRC is activated in response to myocyte stretch and is responsible for enhanced Ca2+ influx and resultant cell damage as measured by creatine phosphokinase efflux [8].
  • By examination of embryonic muscle lineages and biochemical fractionation studies, we demonstrated that epsilon-sarcoglycan is an integral component of the smooth muscle sarcoglycan complex along with beta- and delta-sarcoglycan [4].

Associations of Sgcd with chemical compounds


Other interactions of Sgcd


Analytical, diagnostic and therapeutic context of Sgcd


  1. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Coral-Vazquez, R., Cohn, R.D., Moore, S.A., Hill, J.A., Weiss, R.M., Davisson, R.L., Straub, V., Barresi, R., Bansal, D., Hrstka, R.F., Williamson, R., Campbell, K.P. Cell (1999) [Pubmed]
  2. Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Shiga, K., Yoshioka, H., Matsumiya, T., Kimura, I., Takeda, S., Imamura, M. Exp. Cell Res. (2006) [Pubmed]
  3. Nuclear sequestration of {delta}-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Heydemann, A., Demonbreun, A., Hadhazy, M., Earley, J.U., McNally, E.M. Hum. Mol. Genet. (2007) [Pubmed]
  4. epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to form a unique dystrophin-glycoprotein complex. Straub, V., Ettinger, A.J., Durbeej, M., Venzke, D.P., Cutshall, S., Sanes, J.R., Campbell, K.P. J. Biol. Chem. (1999) [Pubmed]
  5. Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. Wheeler, M.T., Allikian, M.J., Heydemann, A., Hadhazy, M., Zarnegar, S., McNally, E.M. J. Clin. Invest. (2004) [Pubmed]
  6. Fusion of bone marrow-derived stem cells with striated muscle may not be sufficient to activate muscle genes. Cossu, G. J. Clin. Invest. (2004) [Pubmed]
  7. Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle. Lapidos, K.A., Chen, Y.E., Earley, J.U., Heydemann, A., Huber, J.M., Chien, M., Ma, A., McNally, E.M. J. Clin. Invest. (2004) [Pubmed]
  8. A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. Iwata, Y., Katanosaka, Y., Arai, Y., Komamura, K., Miyatake, K., Shigekawa, M. J. Cell Biol. (2003) [Pubmed]
  9. {alpha}7{beta}1 Integrin Does Not Alleviate Disease in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2F. Milner, D.J., Kaufman, S.J. Am. J. Pathol. (2007) [Pubmed]
  10. A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle. Estrada, F.J., Mornet, D., Rosas-Vargas, H., Angulo, A., Hernández, M., Becker, V., Rendón, A., Ramos-Kuri, M., Coral-Vázquez, R.M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  11. Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan. Shi, W., Chen, Z., Schottenfeld, J., Stahl, R.C., Kunkel, L.M., Chan, Y.M. Muscle Nerve (2004) [Pubmed]
  12. A sarcoglycan-dystroglycan complex anchors Dp116 and utrophin in the peripheral nervous system. Imamura, M., Araishi, K., Noguchi, S., Ozawa, E. Hum. Mol. Genet. (2000) [Pubmed]
  13. Dissociation of sarcoglycans and the dystrophin carboxyl terminus from the sarcolemma in enteroviral cardiomyopathy. Lee, G.H., Badorff, C., Knowlton, K.U. Circ. Res. (2000) [Pubmed]
  14. Animal models of muscular dystrophies. Nonaka, I. Lab. Anim. Sci. (1998) [Pubmed]
  15. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. Parsons, S.A., Millay, D.P., Sargent, M.A., McNally, E.M., Molkentin, J.D. Am. J. Pathol. (2006) [Pubmed]
  16. delta- and gamma-Sarcoglycan localization in the sarcoplasmic reticulum of skeletal muscle. Ueda, H., Ueda, K., Baba, T., Ohno, S. J. Histochem. Cytochem. (2001) [Pubmed]
  17. Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: alpha-, beta-, gamma-, or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors. Stedman, H., Wilson, J.M., Finke, R., Kleckner, A.L., Mendell, J. Hum. Gene Ther. (2000) [Pubmed]
  18. Skeletal myosphere-derived progenitor cell transplantation promotes neovascularization in delta-sarcoglycan knockdown cardiomyopathy. Nomura, T., Ashihara, E., Tateishi, K., Asada, S., Ueyama, T., Takahashi, T., Matsubara, H., Oh, H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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