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Gene Review

Sgcg  -  sarcoglycan, gamma (dystrophin-associated...

Mus musculus

Synonyms: 35 kDa dystrophin-associated glycoprotein, 35DAG, 35kDa, 5430420E18Rik, AI642964, ...
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Disease relevance of Sgcg


High impact information on Sgcg


Biological context of Sgcg


Anatomical context of Sgcg


Associations of Sgcg with chemical compounds


Physical interactions of Sgcg

  • The incorporation of alpha-SG into the sarcoglycan complex occurs at the final stage by interaction with gamma-SG [16].

Regulatory relationships of Sgcg


Other interactions of Sgcg


Analytical, diagnostic and therapeutic context of Sgcg


  1. Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Shiga, K., Yoshioka, H., Matsumiya, T., Kimura, I., Takeda, S., Imamura, M. Exp. Cell Res. (2006) [Pubmed]
  2. Muscle degeneration without mechanical injury in sarcoglycan deficiency. Hack, A.A., Cordier, L., Shoturma, D.I., Lam, M.Y., Sweeney, H.L., McNally, E.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Functional nitric oxide synthase mislocalization in cardiomyopathy. Heydemann, A., Huber, J.M., Kakkar, R., Wheeler, M.T., McNally, E.M. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  4. Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice. Sasaoka, T., Imamura, M., Araishi, K., Noguchi, S., Mizuno, Y., Takagoshi, N., Hama, H., Wakabayashi-Takai, E., Yoshimoto-Matsuda, Y., Nonaka, I., Kaneko, K., Yoshida, M., Ozawa, E. Neuromuscul. Disord. (2003) [Pubmed]
  5. Genetic background influences muscular dystrophy. Heydemann, A., Huber, J.M., Demonbreun, A., Hadhazy, M., McNally, E.M. Neuromuscul. Disord. (2005) [Pubmed]
  6. Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy. Wheeler, M.T., Allikian, M.J., Heydemann, A., Hadhazy, M., Zarnegar, S., McNally, E.M. J. Clin. Invest. (2004) [Pubmed]
  7. Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin. Hack, A.A., Ly, C.T., Jiang, F., Clendenin, C.J., Sigrist, K.S., Wollmann, R.L., McNally, E.M. J. Cell Biol. (1998) [Pubmed]
  8. Impact of sarcoglycan complex on mechanical signal transduction in murine skeletal muscle. Barton, E.R. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  9. Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle. Allikian, M.J., Hack, A.A., Mewborn, S., Mayer, U., McNally, E.M. J. Cell. Sci. (2004) [Pubmed]
  10. Analysis of the spatial, temporal and tissue-specific transcription of gamma-sarcoglycan gene using a transgenic mouse. Noguchi, S., Wakabayashi-Takai, E., Sasaoka, T., Ozawa, E. FEBS Lett. (2001) [Pubmed]
  11. Cardiomyopathy is independent of skeletal muscle disease in muscular dystrophy. Zhu, X., Wheeler, M.T., Hadhazy, M., Lam, M.Y., McNally, E.M. FASEB J. (2002) [Pubmed]
  12. Expression of gamma -sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex. Barresi, R., Moore, S.A., Stolle, C.A., Mendell, J.R., Campbell, K.P. J. Biol. Chem. (2000) [Pubmed]
  13. Secondary coronary artery vasospasm promotes cardiomyopathy progression. Wheeler, M.T., Korcarz, C.E., Collins, K.A., Lapidos, K.A., Hack, A.A., Lyons, M.R., Zarnegar, S., Earley, J.U., Lang, R.M., McNally, E.M. Am. J. Pathol. (2004) [Pubmed]
  14. delta- and gamma-Sarcoglycan localization in the sarcoplasmic reticulum of skeletal muscle. Ueda, H., Ueda, K., Baba, T., Ohno, S. J. Histochem. Cytochem. (2001) [Pubmed]
  15. Expression of dystrophin-associated protein 35DAG (A4) and 50DAG (A2) is confined to striated muscles. Yamamoto, H., Mizuno, Y., Hayashi, K., Nonaka, I., Yoshida, M., Ozawa, E. J. Biochem. (1994) [Pubmed]
  16. Specific assembly pathway of sarcoglycans is dependent on beta- and delta-sarcoglycan. Shi, W., Chen, Z., Schottenfeld, J., Stahl, R.C., Kunkel, L.M., Chan, Y.M. Muscle Nerve (2004) [Pubmed]
  17. Sarcoglycans in muscular dystrophy. Hack, A.A., Groh, M.E., McNally, E.M. Microsc. Res. Tech. (2000) [Pubmed]
  18. gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion. Griffin, M.A., Feng, H., Tewari, M., Acosta, P., Kawana, M., Sweeney, H.L., Discher, D.E. J. Cell. Sci. (2005) [Pubmed]
  19. Systemic administration of L-arginine benefits mdx skeletal muscle function. Barton, E.R., Morris, L., Kawana, M., Bish, L.T., Toursel, T. Muscle Nerve (2005) [Pubmed]
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