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Gene Review

Adra2c  -  adrenoceptor alpha 2C

Rattus norvegicus

Synonyms: Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR
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Disease relevance of Adra2c


High impact information on Adra2c


Anatomical context of Adra2c


Associations of Adra2c with chemical compounds


Analytical, diagnostic and therapeutic context of Adra2c

  • To characterize the localization of these subtypes and attempt to correlate subtype expression with physiological significance, the expression of the mRNAs encoding the alpha 1A, alpha 1B, alpha 2A and alpha 2C adrenergic receptor subtypes was examined in the adult rat brain by in situ hybridization histochemistry [13].


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  3. Alpha 2 adrenergic receptor subtypes expressed in Chinese hamster ovary cells activate differentially mitogen-activated protein kinase by a p21ras independent pathway. Flordellis, C.S., Berguerand, M., Gouache, P., Barbu, V., Gavras, H., Handy, D.E., Béréziat, G., Masliah, J. J. Biol. Chem. (1995) [Pubmed]
  4. Cloning and expression of the alpha 2C-adrenergic receptor from the OK cell line. Blaxall, H.S., Cerutis, D.R., Hass, N.A., Iversen, L.J., Bylund, D.B. Mol. Pharmacol. (1994) [Pubmed]
  5. Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord. Stone, L.S., Vulchanova, L., Riedl, M.S., Wang, J., Williams, F.G., Wilcox, G.L., Elde, R. Neuroscience (1999) [Pubmed]
  6. Expression of alpha 2 adrenoceptors during rat brain development--II. Alpha 2C messenger RNA expression and [3H]rauwolscine binding. Winzer-Serhan, U.H., Raymon, H.K., Broide, R.S., Chen, Y., Leslie, F.M. Neuroscience (1997) [Pubmed]
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  8. Axon terminals possessing the alpha 2c-adrenergic receptor in the rat dorsal horn are predominantly excitatory. Olave, M.J., Maxwell, D.J. Brain Res. (2003) [Pubmed]
  9. Alpha-2 adrenoceptor in rat jejunum epithelial cells: characterization with [3H]RX821002 and distribution along the villus-crypt axis. Paris, H., Voisin, T., Remaury, A., Rouyer-Fessard, C., Daviaud, D., Langin, D., Laburthe, M. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  10. Comparison of the binding activities of some drugs on alpha 2A, alpha 2B and alpha 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig. Uhlén, S., Muceniece, R., Rangel, N., Tiger, G., Wikberg, J.E. Pharmacol. Toxicol. (1995) [Pubmed]
  11. Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes. Wallace, D.R., Muskardin, D.T., Zahniser, N.R. Eur. J. Pharmacol. (1994) [Pubmed]
  12. Action of dexmedetomidine on rat locus coeruleus neurones: intracellular recording in vitro. Chiu, T.H., Chen, M.J., Yang, Y.R., Yang, J.J., Tang, F.I. Eur. J. Pharmacol. (1995) [Pubmed]
  13. Expression of multiple alpha adrenergic receptor subtype messenger RNAs in the adult rat brain. McCune, S.K., Voigt, M.M., Hill, J.M. Neuroscience (1993) [Pubmed]
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