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Glycam1  -  glycosylation dependent cell adhesion...

Rattus norvegicus

Synonyms: Endothelial ligand FOR L-selectin, GlyCAM-1, Glycosylation-dependent cell adhesion molecule 1, SGP50, Sulfated 50 kDa glycoprotein
 
 
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High impact information on Glycam1

  • This ligand has been named GlyCAM 1 (Gly-cosylation-dependent Cell Adhesion Molecule 1) because its adhesive interactions with the L selectin lectin domain require that the GlyCAM 1 polypeptide chain be appropriately modified with carbohydrates [1].
  • An additional interesting structure that may have relevance to the association of GlyCAM 1 with the lumenal surface of the endothelium was a potential amphipathic helix at the C terminus of the glycoprotein [1].
  • Finally, immunoprecipitation analysis of [35S]sulfate-labeled rat lymph nodes with either a mouse L selectin IgG chimera or a peptide antiserum directed against a relatively conserved portion of mouse GlyCAM 1 demonstrates a approximately 45-kDa sulfated ligand in rat lymph nodes that is analogous to that previously described for mouse lymph nodes [1].
  • The sequence of this clone reveals a serine/threonine-rich protein that is highly homologous with the mouse GlyCAM 1 [1].
  • HEV express several L-selectin ligands including CD34, GlyCAM-1, MAdCAM-1 and two sulfated glycoproteins (Sgp) of 200 kDa and 170 kDa which remain to be identified [2].
 

Biological context of Glycam1

  • These observations suggest that GlyCAM-1 expressed in the cochlear region is heterogenous in terms of its glycosylation [3].
 

Anatomical context of Glycam1

 

Analytical, diagnostic and therapeutic context of Glycam1

  • Moreover, RT-PCR of the cochlear tissue by the use of specific oligonucleotide primers for rat GlyCAM-1 generated a 378 bp product which was then verified by nucleotide sequencing to represent GlyCAM-1 [3].

References

  1. Cloning of a rat homologue of mouse GlyCAM 1 reveals conservation of structural domains. Dowbenko, D., Watson, S.R., Lasky, L.A. J. Biol. Chem. (1993) [Pubmed]
  2. Novel chondroitin sulfate-modified ligands for L-selectin on lymph node high endothelial venules. Derry, C.J., Faveeuw, C., Mordsley, K.R., Ager, A. Eur. J. Immunol. (1999) [Pubmed]
  3. Constitutive expression of GlyCAM-1 core protein in the rat cochlea. Kanoh, N., Dai, C.F., Tanaka, T., Izawa, D., Li, Y.F., Kawashima, H., Miyasaka, M. Cell Adhes. Commun. (1999) [Pubmed]
 
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