The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Madcam1  -  mucosal vascular addressin cell adhesion...

Rattus norvegicus

Synonyms: MAdCAM-1, Mucosal addressin cell adhesion molecule 1, rMAdCAM-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Madcam1


High impact information on Madcam1

  • The alpha4 integrins, which are constitutively expressed on all human leukocyte subtypes except neutrophils, interact with vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule (MAdCAM-1) on endothelium to mediate selective recruitment of leukocyte subpopulations, other than neutrophils, to sites of inflammation [4].
  • Although alpha4 was expressed at lower levels on neutrophils than all other rat leukocytes, this level of expression was sufficient to mediate significant levels of alpha4- and beta1-dependent neutrophil adhesion to rat and human VCAM-1, and alpha4-dependent, but beta1-independent, adhesion to human MAdCAM-1 [4].
  • A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions [5].
  • HEV express several L-selectin ligands including CD34, GlyCAM-1, MAdCAM-1 and two sulfated glycoproteins (Sgp) of 200 kDa and 170 kDa which remain to be identified [6].
  • Intravital observation demonstrated that in rats with a chronic allergy, T lymphocytes significantly accumulated in villus microvessels as well as in Peyer's patches via a MAdCAM-1-dependent process [1].

Biological context of Madcam1


Anatomical context of Madcam1


Associations of Madcam1 with chemical compounds


Other interactions of Madcam1

  • To distinguish between recognition of MAdCAM-1 and VCAM-1 by alpha 4-containing integrins, recipients were treated with mAb 5F10 against rat VCAM-1 [11].
  • L-selectin (CD62L), the ligand for MAdCAM-1, was strongly expressed on CD45RChighOX62+ cells but not on CD45RClowOX62+ cells [12].

Analytical, diagnostic and therapeutic context of Madcam1


  1. Chronic allergy to dietary ovalbumin induces lymphocyte migration to rat small intestinal mucosa that is inhibited by MAdCAM-1. Ogawa, T., Miura, S., Tsuzuki, Y., Ogino, T., Teramoto, K., Inamura, T., Watanabe, C., Hokari, R., Nagata, H., Ishii, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  2. Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats. Hokari, R., Kato, S., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Miyahara, T., Itoh, K., Sekizuka, E., Nagata, H., Ishii, H., Iizuka, T., Miyasaka, M., Miura, S. Clin. Exp. Immunol. (2001) [Pubmed]
  3. Internal biliary drainage improves decreased number of gut mucosal T lymphocytes and MAdCAM-1 expression in jaundiced rats. Sano, T., Ajiki, T., Takeyama, Y., Kuroda, Y. Surgery (2004) [Pubmed]
  4. Rat neutrophils express alpha4 and beta1 integrins and bind to vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Davenpeck, K.L., Sterbinsky, S.A., Bochner, B.S. Blood (1998) [Pubmed]
  5. Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists. Gong, Y., Barbay, J.K., Dyatkin, A.B., Miskowski, T.A., Kimball, E.S., Prouty, S.M., Fisher, M.C., Santulli, R.J., Schneider, C.R., Wallace, N.H., Ballentine, S.A., Hageman, W.E., Masucci, J.A., Maryanoff, B.E., Damiano, B.P., Andrade-Gordon, P., Hlasta, D.J., Hornby, P.J., He, W. J. Med. Chem. (2006) [Pubmed]
  6. Novel chondroitin sulfate-modified ligands for L-selectin on lymph node high endothelial venules. Derry, C.J., Faveeuw, C., Mordsley, K.R., Ager, A. Eur. J. Immunol. (1999) [Pubmed]
  7. Assignment of the Madcam1 gene to rat chromosome 7q11.2-->q12 by fluorescence in situ hybridization, somatic cell hybrids and linkage analysis. Satoh, H., Iizuka, T., Koike, R., Miyasaka, N., Kitada, K., Kuramoto, T., Serikawa, T., Watanabe, T. Cytogenet. Cell Genet. (1999) [Pubmed]
  8. Effect of FTY720 in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. Sugito, K., Koshinaga, T., Inoue, M., Ikeda, T., Hagiwara, N., Fukuzawa, M. Transplant. Proc. (2005) [Pubmed]
  9. Cloning and characterization of the rat MAdCAM-1 cDNA and gene. Iizuka, T., Koike, R., Miyasaka, N., Miyasaka, M., Watanabe, T. Biochim. Biophys. Acta (1998) [Pubmed]
  10. Expression of lymphocyte homing receptors alpha4beta7 and MAdCAM-l in young and old rats. Schmucker, D.L., Owen, T.M., Issekutz, T.B., Gonzales, L., Wang, R.K. Exp. Gerontol. (2002) [Pubmed]
  11. Migration pathways of CD4 T cell subsets in vivo: the CD45RC- subset enters the thymus via alpha 4 integrin-VCAM-1 interaction. Bell, E.B., Sparshott, S.M., Ager, A. Int. Immunol. (1995) [Pubmed]
  12. Hepatic CCR7lowCD62LlowCD45RClow allograft dendritic cells migrate to the splenic red pulp in immunologically unresponsive rats. Furuhashi, T., Yamaguchi, Y., Wang, F.S., Uchino, S., Okabe, K., Ohshiro, H., Kihara, S., Yamada, S., Mori, K., Ogawa, M. J. Surg. Res. (2005) [Pubmed]
WikiGenes - Universities