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Gene Review

Sell  -  selectin L

Rattus norvegicus

Synonyms: A.11, CD62 antigen-like family member L, L-selectin, LAM-1, LECAM-1, ...
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Disease relevance of Sell


High impact information on Sell

  • Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils [5].
  • Initial leukocyte tethering via the alpha 4-integrin could not be demonstrated in this model, whereas L-selectin did support leukocyte tethering [6].
  • Concomitant with the enhanced lymphocyte adhesion, the cardiac endothelium begins to de novo express sialyl Lewis(a) and sialyl Lewis(x) (sLea and sLex) epitopes, which have been shown to be sequences of L-selectin counterreceptors [7].
  • The endothelium of allografts, but not that of syngeneic grafts or normal controls, also reacted with the L-selectin-immunoglobulin G fusion protein, giving further proof of inducible L-selectin counterreceptors [7].
  • De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion [7].

Chemical compound and disease context of Sell


Biological context of Sell


Anatomical context of Sell

  • During development of fast contracting skeletal muscle in the rat hindleg, embryonic and neonatal forms of the myosin heavy chain are present prior to the accumulation of the adult fast type ( Whalen , R. G., Sell, S. M., Butler-Browne, G.S., Schwartz, K., Bouveret, P., and Pinset -H arstr öm, I. (1981) Nature (Lond.) 292, 805-809) [13].
  • Metabolic radiolabelling studies revealed that thymocytes synthesize markedly less L-selectin than do TDL or LN lymphocytes [1].
  • Early investigations of lymphocyte migration in the rat operationally identified a lymphocyte membrane protein, designated 'A.11', which mediates lymphocyte adherence to lymph node (LN) high endothelial venules (HEV) [1].
  • One of the major characteristics of HEV endothelial cells (HEVEC) is their capacity to incorporate large amounts of sulfate into sialomucin-type counter-receptors for the lymphocyte homing receptor L-selectin [14].
  • Intravenous injection of a rat T-cell line that overexpresses L-selectin showed increased organ infiltration [2].

Associations of Sell with chemical compounds


Regulatory relationships of Sell


Other interactions of Sell


Analytical, diagnostic and therapeutic context of Sell


  1. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Sackstein, R., Meng, L., Xu, X.M., Chin, Y.H. Immunology (1995) [Pubmed]
  2. Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax. Tatewaki, M., Yamaguchi, K., Matsuoka, M., Ishii, T., Miyasaka, M., Mori, S., Takatsuki, K., Watanabe, T. Blood (1995) [Pubmed]
  3. Role of a sialyl Lewis(x)-like epitope selectively expressed on vascular endothelial cells in local skin inflammation of the rat. Akahori, T., Yuzawa, Y., Nishikawa, K., Tamatani, T., Kannagi, R., Miyasaka, M., Okada, H., Hotta, N., Matsuo, S. J. Immunol. (1997) [Pubmed]
  4. Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. Kawashima, H., Watanabe, N., Hirose, M., Sun, X., Atarashi, K., Kimura, T., Shikata, K., Matsuda, M., Ogawa, D., Heljasvaara, R., Rehn, M., Pihlajaniemi, T., Miyasaka, M. J. Biol. Chem. (2003) [Pubmed]
  5. Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils. Strausbaugh, H.J., Green, P.G., Lo, E., Tangemann, K., Reichling, D.B., Rosen, S.D., Levine, J.D. Nat. Med. (1999) [Pubmed]
  6. The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. Johnston, B., Issekutz, T.B., Kubes, P. J. Exp. Med. (1996) [Pubmed]
  7. De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion. Turunen, J.P., Majuri, M.L., Seppo, A., Tiisala, S., Paavonen, T., Miyasaka, M., Lemström, K., Penttilä, L., Renkonen, O., Renkonen, R. J. Exp. Med. (1995) [Pubmed]
  8. Effects of endotoxin on neutrophil-mediated I/R injury in isolated perfused rat hearts. Lipton, B.P., Bautista, A.P., Delcarpio, J.B., McDonough, K.H. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  9. Endotoxin protection from oxygen toxicity: effect on pulmonary neutrophils and L-selectin. Keeney, S.E., Mathews, M.J., Shattuck, K.E., Dallas, D.V. Inflammation (2002) [Pubmed]
  10. Effect of erythromycin on otitis media with effusion in experimental rat model. Enomoto, F., Ichikawa, G., Nagaoka, I., Yamashita, T. Acta oto-laryngologica. Supplementum. (1998) [Pubmed]
  11. Sequence and expression of a rat cDNA for LECAM-1. Watanabe, T., Song, Y., Hirayama, Y., Tamatani, T., Kuida, K., Miyasaka, M. Biochim. Biophys. Acta (1992) [Pubmed]
  12. Differential role of selectins in experimental colitis. Sans, M., Salas, A., Soriano, A., Prats, N., Gironella, M., Pizcueta, P., Elena, M., Anderson, D.C., Piqué, J.M., Panés, J. Gastroenterology (2001) [Pubmed]
  13. Structural differences in the subfragment 1 and rod portions of myosin isozymes from adult and developing rat skeletal muscles. Bugaisky, L.B., Butler-Browne, G.S., Sell, S.M., Whalen, R.G. J. Biol. Chem. (1984) [Pubmed]
  14. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Girard, J.P., Baekkevold, E.S., Feliu, J., Brandtzaeg, P., Amalric, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  15. Enhanced lymphocyte interaction in postcapillary venules of Peyer's patches during fat absorption in rats. Tsuzuki, Y., Miura, S., Kurose, I., Suematsu, M., Higuchi, H., Shigematsu, T., Kimura, H., Serizawa, H., Hokari, R., Akiba, Y., Yagita, H., Okumura, K., Tso, P., Granger, D.N., Ishii, H. Gastroenterology (1997) [Pubmed]
  16. Enhanced interaction of L-selectin with the high endothelial venule ligand via selectively oxidized sialic acids. Norgard, K.E., Han, H., Powell, L., Kriegler, M., Varki, A., Varki, N.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  17. Fucoidin, but not yeast polyphosphomannan PPME, inhibits leukocyte rolling in venules of the rat mesentery. Ley, K., Linnemann, G., Meinen, M., Stoolman, L.M., Gaehtgens, P. Blood (1993) [Pubmed]
  18. Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain. Mousa, S.A., Machelska, H., Schäfer, M., Stein, C. J. Neuroimmunol. (2000) [Pubmed]
  19. Expression of adhesion molecules and leukocyte recruitment into gastric mucosa following ischemia-reperfusion. Andrews, F.J., Malcontenti-Wilson, C., O'Brien, P.E. Dig. Dis. Sci. (1997) [Pubmed]
  20. Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium. Freeman, E.A., Jani, P., Millette, C.E. Cell Commun. Adhes. (2002) [Pubmed]
  21. Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury. Mulligan, M.S., Vaporciyan, A.A., Warner, R.L., Jones, M.L., Foreman, K.E., Miyasaka, M., Todd, R.F., Ward, P.A. J. Immunol. (1995) [Pubmed]
  22. Cloning of a rat homologue of mouse GlyCAM 1 reveals conservation of structural domains. Dowbenko, D., Watson, S.R., Lasky, L.A. J. Biol. Chem. (1993) [Pubmed]
  23. Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Salas, A., Sans, M., Soriano, A., Reverter, J.C., Anderson, D.C., Piqué, J.M., Panés, J. Gut (2000) [Pubmed]
  24. The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Burdon, P.C., Martin, C., Rankin, S.M. Blood (2005) [Pubmed]
  25. Molecular mechanisms underlying lymphocyte recirculation. III. Characterization of the LECAM-1 (L-selectin)-dependent adhesion pathway in rats. Tamatani, T., Kuida, K., Watanabe, T., Koike, S., Miyasaka, M. J. Immunol. (1993) [Pubmed]
  26. Requirements for L-selectin in neutrophil-mediated lung injury in rats. Mulligan, M.S., Miyasaka, M., Tamatani, T., Jones, M.L., Ward, P.A. J. Immunol. (1994) [Pubmed]
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