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Gene Review

Fbp1  -  fructose-1,6-bisphosphatase 1

Rattus norvegicus

Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, FBPase 1, Fbp, Fructose-1,6-bisphosphatase 1, Liver FBPase
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Disease relevance of Fbp1


High impact information on Fbp1


Biological context of Fbp1


Anatomical context of Fbp1


Associations of Fbp1 with chemical compounds


Regulatory relationships of Fbp1


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Analytical, diagnostic and therapeutic context of Fbp1


  1. Lysine 274 is essential for fructose 2,6-bisphosphate inhibition of fructose-1,6-bisphosphatase. el-Maghrabi, M.R., Austin, L.R., Correia, J.J., Pilkis, S.J. J. Biol. Chem. (1992) [Pubmed]
  2. Glucose metabolic adaptations in the intrauterine growth-restricted adult female rat offspring. Garg, M., Thamotharan, M., Rogers, L., Bassilian, S., Lee, W.N., Devaskar, S.U. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  3. Hepatic gluconeogenic enzymes, plasma insulin and glucagon response to magnesium deficiency and fasting. McNeill, D.A., Herbein, J.H., Ritchey, S.J. J. Nutr. (1982) [Pubmed]
  4. Alterations in hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and glucose-6-phosphatase gene expression after hemorrhagic hypotension and resuscitation. Maitra, S.R., Gestring, M., el-Maghrabi, M.R. Shock (1997) [Pubmed]
  5. Carbohydrate metabolism in rat kidney: heterogeneous distribution of glycolytic and gluconeogenic key enzymes. Schmid, H., Scholz, M., Mall, A., Schmidt, U., Guder, W.G., Dubach, U.C. Current problems in clinical biochemistry. (1977) [Pubmed]
  6. cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin. el-Maghrabi, M.R., Pilkis, J., Marker, A.J., Colosia, A.D., D'Angelo, G., Fraser, B.A., Pilkis, S.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Van Schaftingen, E., Hers, H.G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  8. In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase. Riou, J.P., Claus, T.H., Flockhart, D.A., Corbin, J.D., Pilkis, S.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  9. Amino acid sequence of the COOH-terminal region of fructose-1,6-bisphosphatases in relation to cyclic AMP-dependent phosphorylation. Rittenhouse, J., Chatterjee, T., Marcus, F., Reardon, I., Heinrikson, R.L. J. Biol. Chem. (1983) [Pubmed]
  10. Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on the catalytic properties. Pedrosa, F.O., Pontremoli, S., Horecker, B.L. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  11. Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis. Jin, E.S., Uyeda, K., Kawaguchi, T., Burgess, S.C., Malloy, C.R., Sherry, A.D. J. Biol. Chem. (2003) [Pubmed]
  12. Fructose-1,6-biphosphatase activity in the intestinal mucosa of developing rats. Westbury, K., Hahn, P. Am. J. Physiol. (1984) [Pubmed]
  13. Mechanism of action of 2,5-anhydro-D-mannitol in hepatocytes. Effects of phosphorylated metabolites on enzymes of carbohydrate metabolism. Riquelme, P.T., Wernette-Hammond, M.E., Kneer, N.M., Lardy, H.A. J. Biol. Chem. (1984) [Pubmed]
  14. Inhibition by substrate of fructose 1,6-bisphosphatase purified from rat kidney cortex. Calculation of the kinetic constants of the enzyme. Vargas, A.M., Sola, M.M., Bounias, M. J. Biol. Chem. (1990) [Pubmed]
  15. Amino acid sequence of the phosphorylation site of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Murray, K.J., El-Maghrabi, M.R., Kountz, P.D., Lukas, T.J., Soderling, T.R., Pilkis, S.J. J. Biol. Chem. (1984) [Pubmed]
  16. Stimulation of fructose-1,6-biphosphatase activity and synthesis in the cerebral cortex of rats submitted to the convulsant methionine sulfoximine. Hevor, T., Gayet, J. J. Neurochem. (1981) [Pubmed]
  17. Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver. Tejwani, G.A., Pedrosa, F.O., Pontremoli, S., Horecker, B.L. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  18. Normalization of six key hepatic enzymes after fetal pancreas transplantation in diabetic rats. Makoff, R.K., Brown, J., Mullen, Y., Clark, W.R. Diabetes (1983) [Pubmed]
  19. The zonation of liver and the distribution of fructose 2,6-bisphosphate in rat liver. Wals, P.A., Palacin, M., Katz, J. J. Biol. Chem. (1988) [Pubmed]
  20. The xenobiotic methionine sulfoximine modulates carbohydrate anabolism and related genes expression in rodent brain. Hélary-Bernard, K., Ardourel, M.Y., Cloix, J.F., Hevor, T. Toxicology (2000) [Pubmed]
  21. Effects of epinephrine, glucagon and insulin on the activity and degree of phosphorylation of fructose-1,6-bisphosphatase in cultured hepatocytes. Ekdahl, K.N., Ekman, P. Biochim. Biophys. Acta (1987) [Pubmed]
  22. Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon. Groen, A.K., van Roermund, C.W., Vervoorn, R.C., Tager, J.M. Biochem. J. (1986) [Pubmed]
  23. Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver. Gerbracht, U., Einig, C., Oesterle, D., Deml, E., Schlatterer, B., Eigenbrodt, E. Carcinogenesis (1990) [Pubmed]
  24. Mechanism of glucagon stimulation of fructose-1,6-bisphosphatase in rat hepatocytes. Involvement of a low-Mr activator. Casteleijn, E., van Rooij, H.C., van Berkel, T.J., Koster, J.F. FEBS Lett. (1986) [Pubmed]
  25. The effect of calcium ions on subcellular localization of aldolase-FBPase complex in skeletal muscle. Mamczur, P., Rakus, D., Gizak, A., Dus, D., Dzugaj, A. FEBS Lett. (2005) [Pubmed]
  26. Nuclear localization of liver FBPase isoenzyme in kidney and liver. Yáñez, A.J., Bertinat, R., Concha, I.I., Slebe, J.C. FEBS Lett. (2003) [Pubmed]
  27. Changes in hepatic carbohydrate metabolism after jejunoileal bypass. Stein, T.A., Mandell, C., Wazna, M., Wise, L. J. Nutr. (1982) [Pubmed]
  28. Predominant periportal expression of the fructose 1,6-bisphosphatase gene in rat liver: dynamics during the daily feeding rhythm and starvation-refeeding cycle. Eilers, F., Modaressi, S., Jungermann, K. Histochem. Cell Biol. (1995) [Pubmed]
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