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Gene Review

Fbp1  -  fructose bisphosphatase 1

Mus musculus

Synonyms: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, FBPase 1, FBPase 3, FBPase brain isoform, FBPase liver, ...
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Disease relevance of Fbp1


High impact information on Fbp1

  • By controlling the level of fructose-2,6-bisphosphate, an allosteric activator of the glycolytic enzyme 6-phosphofructo-1-kinase and an inhibitor of the gluconeogenic enzyme fructose-1,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase regulates hepatic glucose output [6].
  • A L. major FBP-null mutant was unable to grow in the absence of hexose, and suspension in glycerol-containing medium resulted in rapid depletion of internal carbohydrate reserves [7].
  • Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase [7].
  • L. major FBP was constitutively expressed in both extracellular and intracellular stages and was primarily targeted to glycosomes, modified peroxisomes that also contain glycolytic enzymes [7].
  • To define the biochemical composition of the phagosome and carbon source requirements of intracellular stages of L. major, we investigated the role and requirement for the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP) [7].

Biological context of Fbp1


Anatomical context of Fbp1


Associations of Fbp1 with chemical compounds


Other interactions of Fbp1


Analytical, diagnostic and therapeutic context of Fbp1


  1. One of the retinoic acid-inducible cDNA clones in mouse embryonal carcinoma F9 cells encodes a novel isoenzyme of fructose 1,6-bisphosphatase. Nomura, M., Takihara, Y., Yasunaga, T., Shimada, K. FEBS Lett. (1994) [Pubmed]
  2. Various fructose-1,6-bisphosphatase mRNAs in mouse brain, liver, kidney and heart. Cloix, J.F., Beaulieu, E., Hevor, T. Neuroreport (1997) [Pubmed]
  3. Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM. Andrikopoulos, S., Rosella, G., Gaskin, E., Thorburn, A., Kaczmarczyk, S., Zajac, J.D., Proietto, J. Diabetes (1993) [Pubmed]
  4. Identification and cloning of a fur homolog from Neisseria gonorrhoeae. Berish, S.A., Subbarao, S., Chen, C.Y., Trees, D.L., Morse, S.A. Infect. Immun. (1993) [Pubmed]
  5. Characterization of ferric and ferrous iron transport systems in Vibrio cholerae. Wyckoff, E.E., Mey, A.R., Leimbach, A., Fisher, C.F., Payne, S.M. J. Bacteriol. (2006) [Pubmed]
  6. Overexpression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. Wu, C., Okar, D.A., Newgard, C.B., Lange, A.J. J. Clin. Invest. (2001) [Pubmed]
  7. Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Naderer, T., Ellis, M.A., Sernee, M.F., De Souza, D.P., Curtis, J., Handman, E., McConville, M.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Fructose-bisphosphatase as a substrate of cyclic AMP-dependent protein kinase. Hosey, M.M., Marcus, F. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  9. Hypoglycaemic effect of AICAriboside in mice. Vincent, M.F., Erion, M.D., Gruber, H.E., Van den Berghe, G. Diabetologia (1996) [Pubmed]
  10. Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis. Lamont, B.J., Visinoni, S., Fam, B.C., Kebede, M., Weinrich, B., Papapostolou, S., Massinet, H., Proietto, J., Favaloro, J., Andrikopoulos, S. Endocrinology (2006) [Pubmed]
  11. Fructose bisphosphatase isozymes of the mouse. I. Inheritance. Nash, H.R., Challinor, P.R. Biochem. Genet. (1985) [Pubmed]
  12. Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes. Tillmann, H., Stein, S., Liehr, T., Eschrich, K. Gene (2000) [Pubmed]
  13. Stable transfection of cDNAs targeting specific steps of glycogen metabolism supports the existence of active gluconeogenesis in mouse cultured astrocytes. Bernard-Hélary, K., Ardourel, M., Magistretti, P., Hévor, T., Cloix, J.F. Glia (2002) [Pubmed]
  14. Mouse thymoma cell line expresses a gluconeogenic enzyme, fructose 1,6-bisphosphatase. Mizunuma, H., Tashima, Y. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  15. Characterization of the mouse liver fructose-1,6-bisphosphatase gene. Stein, S., Liehr, T., Eschrich, K. Gene (2001) [Pubmed]
  16. PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Zinker, B.A., Rondinone, C.M., Trevillyan, J.M., Gum, R.J., Clampit, J.E., Waring, J.F., Xie, N., Wilcox, D., Jacobson, P., Frost, L., Kroeger, P.E., Reilly, R.M., Koterski, S., Opgenorth, T.J., Ulrich, R.G., Crosby, S., Butler, M., Murray, S.F., McKay, R.A., Bhanot, S., Monia, B.P., Jirousek, M.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Glycogen synthesis and immunocytochemical study of fructose-1,6-biphosphatase in methionine sulfoximine epileptogenic rodent brain. Hevor, T.K., Delorme, P., Beauvillain, J.C. J. Cereb. Blood Flow Metab. (1986) [Pubmed]
  18. Effect of starvation on glutamine ammoniagenesis and gluconeogenesis in isolated mouse kidney tubules. Conjard, A., Brun, V., Martin, M., Baverel, G., Ferrier, B. Biochem. J. (2002) [Pubmed]
  19. Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null mice. Hansson, O., Donsmark, M., Ling, C., Nevsten, P., Danfelter, M., Andersen, J.L., Galbo, H., Holm, C. J. Lipid Res. (2005) [Pubmed]
  20. Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Shin, D.J., McGrane, M.M. J. Nutr. (1997) [Pubmed]
  21. Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver. Hagopian, K., Ramsey, J.J., Weindruch, R. Exp. Gerontol. (2003) [Pubmed]
  22. Analysis of the activity and identification of enzymes after separation of cytosol proteins in mouse liver by microscale nondenaturing two-dimensional electrophoresis. Shimazaki, Y., Sugawara, Y., Ohtsuka, Y., Manabe, T. Proteomics (2003) [Pubmed]
  23. Nondenaturing two-dimensional electrophoresis enzyme profile involving activity and sequence structure of cytosol proteins from mouse liver. Shimazaki, Y., Sugawara, Y., Manabe, T. Proteomics (2004) [Pubmed]
  24. Spatial and temporal expression of folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice. Saitsu, H., Ishibashi, M., Nakano, H., Shiota, K. Dev. Dyn. (2003) [Pubmed]
  25. Induction of fructose 1,6-bisphosphatase and glucose 6-phosphatase in fetal mouse liver. Tashima, Y., Mizunuma, H., Kumegawa, M. Arch. Biochem. Biophys. (1983) [Pubmed]
  26. Distribution of a COOH-terminal amino acid extension of liver fructose-1,6-bisphosphatase among rodent species. Rittenhouse, J., Nevo, E., Marcus, F. Comp. Biochem. Physiol., B (1985) [Pubmed]
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