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Gene Review

GABPB1  -  GA binding protein transcription factor,...

Homo sapiens

Synonyms: BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, ...
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Disease relevance of GABPB2


High impact information on GABPB2

  • Genomic and cDNA copies of the newly defined Gabpb2 gene were cloned and characterized, providing the conceptually translated amino acid sequence of GABP beta 2-1 [3].
  • As in the functionally related RCO4 gene, tandemly arranged NRF-2 sites are essential for the activity of the proximal MCO5b promoter, further substantiating a role for NRF-2 in respiratory chain expression [1].
  • We have now purified NRF-2 to homogeneity from HeLa cells and find that it consists of five polypeptides, only one of which has intrinsic DNA-binding ability [1].
  • Nuclear respiratory factor 2 (NRF-2) is a nuclear transcription factor that activates the proximal promoter of the rat cytochrome c oxidase subunit IV (RCO4) gene through tandem sequence elements [1].
  • Heterodimers of E4TF1-47 and E4TF1-60 weakly stimulated transcription in vitro [4].

Biological context of GABPB2


Anatomical context of GABPB2

  • Nuclear respiratory factor 2 (NRF-2) was previously purified to near homogeneity from HeLa cells on the basis of its ability to bind tandem recognition sites in the rat cytochrome oxidase subunit IV (RCO4) promoter [6].
  • The expression pattern of NRF-2 alpha mRNA in the normal striate cortex paralleled that of CO activity [9].

Physical interactions of GABPB2


Other interactions of GABPB2


Analytical, diagnostic and therapeutic context of GABPB2


  1. Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Virbasius, J.V., Virbasius, C.A., Scarpulla, R.C. Genes Dev. (1993) [Pubmed]
  2. Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. Sowa, Y., Shiio, Y., Fujita, T., Matsumoto, T., Okuyama, Y., Kato, D., Inoue, J., Sawada, J., Goto, M., Watanabe, H., Handa, H., Sakai, T. Cancer Res. (1997) [Pubmed]
  3. Molecular and genetic characterization of GABP beta. de la Brousse, F.C., Birkenmeier, E.H., King, D.S., Rowe, L.B., McKnight, S.L. Genes Dev. (1994) [Pubmed]
  4. Transcriptional activation through the tetrameric complex formation of E4TF1 subunits. Sawada, J., Goto, M., Sawa, C., Watanabe, H., Handa, H. EMBO J. (1994) [Pubmed]
  5. Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. Marie, S., Race, V., Nassogne, M.C., Vincent, M.F., Van den Berghe, G. Am. J. Hum. Genet. (2002) [Pubmed]
  6. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Gugneja, S., Virbasius, J.V., Scarpulla, R.C. Mol. Cell. Biol. (1995) [Pubmed]
  7. cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. Watanabe, H., Sawada, J., Yano, K., Yamaguchi, K., Goto, M., Handa, H. Mol. Cell. Biol. (1993) [Pubmed]
  8. NRF-2 transcription factor is essential in promoting human Tomm70 gene expression. Blesa, J.R., Hernández, J.M., Hernández-Yago, J. Mitochondrion (2004) [Pubmed]
  9. Human nuclear respiratory factor 2 alpha subunit cDNA: isolation, subcloning, sequencing, and in situ hybridization of transcripts in normal and monocularly deprived macaque visual system. Guo, A., Nie, F., Wong-Riley, M. J. Comp. Neurol. (2000) [Pubmed]
  10. Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene. Hayashi, R., Ueda, T., Farwell, M.A., Takeuchi, N. Mitochondrion (2007) [Pubmed]
  11. Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Virbasius, J.V., Scarpulla, R.C. Mol. Cell. Biol. (1991) [Pubmed]
  12. Redox regulation of GA-binding protein-alpha DNA binding activity. Martin, M.E., Chinenov, Y., Yu, M., Schmidt, T.K., Yang, X.Y. J. Biol. Chem. (1996) [Pubmed]
  13. Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation. Sawa, C., Goto, M., Suzuki, F., Watanabe, H., Sawada, J., Handa, H. Nucleic Acids Res. (1996) [Pubmed]
  14. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. Overman, R.G., Enderle, P.J., Farrow, J.M., Wiley, J.E., Farwell, M.A. Biochim. Biophys. Acta (2003) [Pubmed]
  15. Characteristics and clustering of human ribosomal protein genes. Ishii, K., Washio, T., Uechi, T., Yoshihama, M., Kenmochi, N., Tomita, M. BMC Genomics (2006) [Pubmed]
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