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Gene Review

MAGED2  -  melanoma antigen family D, 2

Homo sapiens

Synonyms: 11B6, BCG-1, BCG1, Breast cancer-associated gene 1 protein, HCA10, ...
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Disease relevance of MAGED2


High impact information on MAGED2


Biological context of MAGED2


Anatomical context of MAGED2


Associations of MAGED2 with chemical compounds

  • Most of the BCG1-controlled genes are still expressed in adenylate cyclase (bac) mutants in planta, suggesting that BCG1 is involved in at least one additional signaling cascade in addition to the cAMP-depending pathway [15].
  • Application of exogenous cyclic AMP restored the wild-type growth pattern of bcg1 mutants, but not the protease secretion, implicating an essential role of BCG1 in different signaling pathways [16].

Other interactions of MAGED2


Analytical, diagnostic and therapeutic context of MAGED2


  1. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese, K., Kloos, D.U., Wehnert, M., Seidel, B., Wieacker, P. Cytogenet. Cell Genet. (2001) [Pubmed]
  2. Isolation of genes overexpressed in freshly isolated breast cancer specimens. Kurt, R.A., Urba, W.J., Schoof, D.D. Breast Cancer Res. Treat. (2000) [Pubmed]
  3. Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed. Modlin, I.M., Kidd, M., Latich, I., Zikusoka, M.N., Eick, G.N., Mane, S.M., Camp, R.L. Ann. Surg. (2006) [Pubmed]
  4. The role of genetic markers--NAP1L1, MAGE-D2, and MTA1--in defining small-intestinal carcinoid neoplasia. Kidd, M., Modlin, I.M., Mane, S.M., Camp, R.L., Eick, G., Latich, I. Ann. Surg. Oncol. (2006) [Pubmed]
  5. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Lane, T.F., Deng, C., Elson, A., Lyu, M.S., Kozak, C.A., Leder, P. Genes Dev. (1995) [Pubmed]
  6. A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants. Reidt, W., Wurz, R., Wanieck, K., Chu, H.H., Puchta, H. EMBO J. (2006) [Pubmed]
  7. Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Tan, Y., Raychaudhuri, P., Costa, R.H. Mol. Cell. Biol. (2007) [Pubmed]
  8. A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. Burger, A.M., Gao, Y., Amemiya, Y., Kahn, H.J., Kitching, R., Yang, Y., Sun, P., Narod, S.A., Hanna, W.M., Seth, A.K. Cancer Res. (2005) [Pubmed]
  9. Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients. Kasper, G., Weiser, A.A., Rump, A., Sparbier, K., Dahl, E., Hartmann, A., Wild, P., Schwidetzky, U., Castaños-Vélez, E., Lehmann, K. Int. J. Cancer (2005) [Pubmed]
  10. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. Harper, R., Xu, C., Di, P., Chen, Y., Privalsky, M., Wu, R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Cancer/testis antigens: structural and immunobiological properties. Kirkin, A.F., Dzhandzhugazyan, K.N., Zeuthen, J. Cancer Invest. (2002) [Pubmed]
  12. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. Bertrand, M., Huijbers, I., Chomez, P., De Backer, O. Dev. Dyn. (2004) [Pubmed]
  13. Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Furuta, S., Jiang, X., Gu, B., Cheng, E., Chen, P.L., Lee, W.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. A novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin. Hennuy, B., Reiter, E., Cornet, A., Bruyninx, M., Daukandt, M., Houssa, P., N'Guyen, V.H., Closset, J., Hennen, G. Endocrinology (2000) [Pubmed]
  15. Identification of Botrytis cinerea genes up-regulated during infection and controlled by the Galpha subunit BCG1 using suppression subtractive hybridization (SSH). Schulze Gronover, C., Schorn, C., Tudzynski, B. Mol. Plant Microbe Interact. (2004) [Pubmed]
  16. The role of G protein alpha subunits in the infection process of the gray mold fungus Botrytis cinerea. Gronover, C.S., Kasulke, D., Tudzynski, P., Tudzynski, B. Mol. Plant Microbe Interact. (2001) [Pubmed]
  17. Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma. Theisinger, B., Welter, C., Seitz, G., Rio, M.C., Lathe, R., Chambon, P., Blin, N. Eur. J. Cancer (1991) [Pubmed]
  18. The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. Eckel, K.L., Tentler, J.J., Cappetta, G.J., Diamond, S.E., Gutierrez-Hartmann, A. DNA Cell Biol. (2003) [Pubmed]
  19. Structural characterization and chromosomal localization of the MAGE-E1 gene. Kawano, Y., Sasaki, M., Nakahira, K., Yoshimine, T., Shimizu, K., Wada, H., Ikenaka, K. Gene (2001) [Pubmed]
  20. Mammaglobin as a novel breast cancer biomarker: multigene reverse transcription-PCR assay and sandwich ELISA. Zehentner, B.K., Persing, D.H., Deme, A., Toure, P., Hawes, S.E., Brooks, L., Feng, Q., Hayes, D.C., Critichlow, C.W., Houghton, R.L., Kiviat, N.B. Clin. Chem. (2004) [Pubmed]
  21. Molecular detection of breast cancer cells in the peripheral blood of advanced-stage breast cancer patients using multimarker real-time reverse transcription-polymerase chain reaction and a novel porous barrier density gradient centrifugation technology. Baker, M.K., Mikhitarian, K., Osta, W., Callahan, K., Hoda, R., Brescia, F., Kneuper-Hall, R., Mitas, M., Cole, D.J., Gillanders, W.E. Clin. Cancer Res. (2003) [Pubmed]
  22. Improving sensitivity of electrophoretic heteroduplex analysis using nucleosides as additives: Application to the breast cancer predisposition gene BRCA2. Weber, J., Looten, R., Houdayer, C., Stoppa-Lyonnet, D., Viovy, J.L. Electrophoresis (2006) [Pubmed]
  23. Measurement of UVB-Induced DNA damage and its consequences in models of immunosuppression. Yarosh, D.B., Boumakis, S., Brown, A.B., Canning, M.T., Galvin, J.W., Both, D.M., Kraus, E., O'Connor, A., Brown, D.A. Methods (2002) [Pubmed]
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