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ACOT11  -  acyl-CoA thioesterase 11

Homo sapiens

Synonyms: Acyl-CoA thioester hydrolase 11, Acyl-CoA thioesterase 11, Acyl-coenzyme A thioesterase 11, Adipose-associated thioesterase, BFIT, ...
 
 
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Disease relevance of ACOT11

  • BFIT was mapped to syntenic regions of chromosomes 1 (human) and 4 (mouse) associated with body fatness and diet-induced obesity, potentially linking a deficit of BFIT activity with exacerbation of these traits [1].
  • The Dispersed Neuroendocrine System, Its Bronchopulmonary Elements, and Neuroendocrine Tumors Presumed to be Derived from Them: Myths, Mistaken Notions, and Misunderstandings [2].
 

Psychiatry related information on ACOT11

 

High impact information on ACOT11

  • Cells microinjected with DNA fragments containing about 80, 70 or 60% of thea early SV40 genome were still stained positively when challenged with antibody against T antigen, and the same cells were stimulated for cellular DNA synthesis when about 70% or more of the early viral information was available [5].
  • Human Monocytes, but not Dendritic Cells Derived from Them, Are Defective in Base Excision Repair and Hypersensitive to Methylating Agents [6].
  • Sazetidine-A, A Novel Ligand That Desensitizes {alpha}4beta2 Nicotinic Acetylcholine Receptors without Activating Them [7].
  • Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through {alpha}3- and {alpha}6-Containing Integrins [8].
  • Metabolism of xanthine and hypoxanthine in the tea plant (Thea sinensis L.) [9].
 

Biological context of ACOT11

  • Database searching shows no homology to other known proteins, but reveals high similarities to two mouse expressed sequence tags (91% and 93% homology) and human mRNA for KIAA0707 hypothetical protein (50% homology) of unknown function [10].
  • Some 30 randomly selected men, aged 50-59 years, were investigated in each of 4 areas--Copenhagen, Them (rural Denmark), Helsinki, and Parikkala (rural Finland)--to determine the relationship of diet, gut transit time, fecal bulk, fecal bacteriology, bile acid concentration, and urinary volatile phenol production to large bowel cancer risk [11].
 

Anatomical context of ACOT11

  • Factors in recovery from spinal cord injury. Summarized transactions of a conference held May 24-25, 1976, in Granville, Ohio, under the auspices of Denison University and Help Them Walk Again Foundation [12].
 

Associations of ACOT11 with chemical compounds

  • Non-linear least-square fitting allows one to estimate thea binding constants, and therefore the free energy of binding of either magnesium or fructose bisphosphate to the various forms of the enzyme [13].
  • When the hot water extract and the methanol extract of 29 samples were measured for their antifungal activity against Arthrinium sacchari M001 and Chaetomium funicola M002 strains, five samples, Acer nikoense, Glycyrrhiza glabra, Lagerstroemia speciosa, Psidium guajava and Thea sinensis, showed high activity [14].
 

Analytical, diagnostic and therapeutic context of ACOT11

  • Thea addiction may persist for years without acknowledgement by a patient, doctor, or family, although there is usually a progressive constriction of social and occupational functioning [15].
  • The answer to the question posed in the title, "Small Round Cell Neoplasms: Can Electron Microscopy and Immunohistochemical Studies Accurately Classify Them?", is obviously "yes"; but a qualified yes--generally yes, perhaps with expertise usually yes, but never just plain yes [16].
  • EEG recordings indicated a slowing of alpha waves with some thea and delta waves from the frontal areas after rotation [17].

References

  1. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. Adams, S.H., Chui, C., Schilbach, S.L., Yu, X.X., Goddard, A.D., Grimaldi, J.C., Lee, J., Dowd, P., Colman, S., Lewin, D.A. Biochem. J. (2001) [Pubmed]
  2. The Dispersed Neuroendocrine System, Its Bronchopulmonary Elements, and Neuroendocrine Tumors Presumed to be Derived from Them: Myths, Mistaken Notions, and Misunderstandings. Warren, W.H., Hammar, S.P. Semin. Thorac. Cardiovasc. Surg. (2006) [Pubmed]
  3. Dietary patterns in Them and Copenhagen, Denmark. Helms, P., Jørgensen, I.M., Paerregaard, A., Bjerrum, L., Poulsen, L., Mosbech, J. Nutrition and cancer. (1982) [Pubmed]
  4. Acting on Impulse: What's New About Impulse-Control Disorders and Why Would We Consider Them Forms of Behavioral Addiction? Hollander, E. CNS spectrums (2006) [Pubmed]
  5. Mapping of early SV40-specific functions by microinjection of different early viral DNA fragments. Mueller, C., Graessmann, A., Graessmann, M. Cell (1978) [Pubmed]
  6. Human Monocytes, but not Dendritic Cells Derived from Them, Are Defective in Base Excision Repair and Hypersensitive to Methylating Agents. Briegert, M., Kaina, B. Cancer Res. (2007) [Pubmed]
  7. Sazetidine-A, A Novel Ligand That Desensitizes {alpha}4beta2 Nicotinic Acetylcholine Receptors without Activating Them. Xiao, Y., Fan, H., Musachio, J.L., Wei, Z.L., Chellappan, S.K., Kozikowski, A.P., Kellar, K.J. Mol. Pharmacol. (2006) [Pubmed]
  8. Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through {alpha}3- and {alpha}6-Containing Integrins. Aisenbrey, S., Zhang, M., Bacher, D., Yee, J., Brunken, W.J., Hunter, D.D. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  9. Metabolism of xanthine and hypoxanthine in the tea plant (Thea sinensis L.). Suzuki, T., Takahashi, E. Biochem. J. (1975) [Pubmed]
  10. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. Suematsu, N., Okamoto, K., Shibata, K., Nakanishi, Y., Isohashi, F. Eur. J. Biochem. (2001) [Pubmed]
  11. Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland. Jensen, O.M., MacLennan, R., Wahrendorf, J. Nutrition and cancer. (1982) [Pubmed]
  12. Factors in recovery from spinal cord injury. Summarized transactions of a conference held May 24-25, 1976, in Granville, Ohio, under the auspices of Denison University and Help Them Walk Again Foundation. Pettegrew, R.K., Windle, W.F. Exp. Neurol. (1976) [Pubmed]
  13. Substrate-binding isotherms of spinach chloroplastic fructose-1,6-bisphosphatase and the photoregulation of the Calvin cycle. Meunier, J.C., Buc, J., Soulié, J.M., Pradel, J., Ricard, J. Eur. J. Biochem. (1981) [Pubmed]
  14. Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola. Sato, J., Goto, K., Nanjo, F., Kawai, S., Murata, K. J. Biosci. Bioeng. (2000) [Pubmed]
  15. Treatment of iatrogenic drug dependence in the general hospital. Streltzer, J. General hospital psychiatry. (1980) [Pubmed]
  16. Small round cell neoplasms: can electron microscopy and immunohistochemical studies accurately classify them? Mierau, G.W., Berry, P.J., Orsini, E.N. Ultrastructural pathology. (1985) [Pubmed]
  17. Therapeutic effects of antimotion sickness medications on the secondary symptoms of motion sickness. Wood, C.D., Stewart, J.J., Wood, M.J., Manno, J.E., Manno, B.R., Mims, M.E. Aviation, space, and environmental medicine. (1990) [Pubmed]
 
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