Gene Review:
TINF2 - TERF1 (TRF1)-interacting nuclear factor 2
Homo sapiens
Synonyms:
DKCA3, TERF1-interacting nuclear factor 2, TIN2, TRF1-interacting nuclear protein 2
- Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Matsutani, N., Yokozaki, H., Tahara, E., Tahara, H., Kuniyasu, H., Haruma, K., Chayama, K., Yasui, W., Tahara, E. Int. J. Oncol. (2001)
- Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers. Yamada, M., Tsuji, N., Nakamura, M., Moriai, R., Kobayashi, D., Yagihashi, A., Watanabe, N. Anticancer Res. (2002)
- Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia. Bellon, M., Datta, A., Brown, M., Pouliquen, J.F., Couppie, P., Kazanji, M., Nicot, C. Int. J. Cancer (2006)
- TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Ye, J.Z., de Lange, T. Nat. Genet. (2004)
- TIN2, a new regulator of telomere length in human cells. Kim, S.H., Kaminker, P., Campisi, J. Nat. Genet. (1999)
- Polypeptide components of telomere nucleoprotein complex. Kuimov, A.N. Biochemistry Mosc. (2004)
- The human TINF2 gene organisation and chromosomal localization. Simonsson, T. Biochimie (2001)
- Shelterin: the protein complex that shapes and safeguards human telomeres. de Lange, T. Genes Dev. (2005)
- Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. Kaminker, P., Plachot, C., Kim, S.H., Chung, P., Crippen, D., Petersen, O.W., Bissell, M.J., Campisi, J., Lelièvre, S.A. J. Cell. Sci. (2005)
- Decreased gene expression for telomeric-repeat binding factors and TIN2 in malignant hematopoietic cells. Yamada, K., Yagihashi, A., Yamada, M., Asanuma, K., Moriai, R., Kobayashi, D., Tsuji, N., Watanabe, N. Anticancer Res. (2002)
- TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. Ye, J.Z., Donigian, J.R., van Overbeek, M., Loayza, D., Luo, Y., Krutchinsky, A.N., Chait, B.T., de Lange, T. J. Biol. Chem. (2004)
- TIN2 mediates functions of TRF2 at human telomeres. Kim, S.H., Beausejour, C., Davalos, A.R., Kaminker, P., Heo, S.J., Campisi, J. J. Biol. Chem. (2004)
- A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. O'Connor, M.S., Safari, A., Xin, H., Liu, D., Songyang, Z. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Oh, B.K., Kim, Y.J., Park, C., Park, Y.N. Am. J. Pathol. (2005)