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Gene Review

Map3k3  -  mitogen-activated protein kinase kinase...

Mus musculus

Synonyms: AW548911, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK 3, ...
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High impact information on Map3k3

  • Map3k3 disruption did not alter the expression of the genes encoding Vegf-1, angiopoietin or their receptors [1].
  • The development of embryonic, but not maternal, blood vessels in the placentas of Map3k3-/- embryos was impaired, revealing an intrinsic defect in Map3k3-/- endothelial cells [1].
  • Map3k3-/- embryos died at approximately embryonic day (E) 11, displaying disruption of blood vessel development and the structural integrity of the yolk sac [1].
  • Through its ability to bind actin, relocalize to Rac-containing membrane ruffles and its obligate requirement for p38 activation in response to sorbitol, we have termed this protein osmosensing scaffold for MEKK3 (OSM) [2].
  • Taken together, these studies suggest a mechanism whereby RIP1 may mediate the p38 MAP kinase response to TNF-alpha, by recruiting the MAP3K MEKK3 [3].

Biological context of Map3k3


Anatomical context of Map3k3


Associations of Map3k3 with chemical compounds

  • Recently, a novel scaffolding protein called Osmosensing Scaffold for MEKK3 (OSM) was linked to p38 MAPK activation in response to sorbitol-induced hypertonicity [7].

Physical interactions of Map3k3


Other interactions of Map3k3


  1. Mekk3 is essential for early embryonic cardiovascular development. Yang, J., Boerm, M., McCarty, M., Bucana, C., Fidler, I.J., Zhuang, Y., Su, B. Nat. Genet. (2000) [Pubmed]
  2. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Uhlik, M.T., Abell, A.N., Johnson, N.L., Sun, W., Cuevas, B.D., Lobel-Rice, K.E., Horne, E.A., Dell'Acqua, M.L., Johnson, G.L. Nat. Cell Biol. (2003) [Pubmed]
  3. The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Lee, T.H., Huang, Q., Oikemus, S., Shank, J., Ventura, J.J., Cusson, N., Vaillancourt, R.R., Su, B., Davis, R.J., Kelliher, M.A. Mol. Cell. Biol. (2003) [Pubmed]
  4. Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3. Ellinger-Ziegelbauer, H., Kelly, K., Siebenlist, U. Mol. Cell. Biol. (1999) [Pubmed]
  5. The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. Abbasi, S., Su, B., Kellems, R.E., Yang, J., Xia, Y. J. Biol. Chem. (2005) [Pubmed]
  6. MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colony-stimulating factor production in macrophages. Kim, K., Duramad, O., Qin, X.F., Su, B. Immunology (2007) [Pubmed]
  7. Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation. Fong, B., Watson, P.H., Watson, A.J. BMC Dev. Biol. (2007) [Pubmed]
  8. MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome. Hagemann, C., Patel, R., Blank, J.L. Biochem. J. (2003) [Pubmed]
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