Disease relevance of Prl2c4

• CONCLUSIONS: Overexpression of Mrp 3 and Mrp 4 in CBDL mice is FXR independent and could play an important role in the adaptive hepatic ABC transporter response to cholestasis [1].
• Transgenic mice, expressing lacZ under the combined control of the cytomegalovirus immediate early enhancer and the Mrp3 flanking sequences, demonstrate wound- and hair cycle-induced transgene expression [2].
• Previous reports showed hyperbilirubinemia and induction of Mrp3 in the hepatocyte sinusoidal membrane in the mutant rats [3].

High impact information on Prl2c4

• The results reported here suggest that MRP3 may participate in wound healing and hair follicle cycle as a growth factor and/or angiogenesis factor [2].
• Here it is demonstrated that Mrp3 is induced in wound edge keratinocytes during cutaneous wound healing and also temporally appears in the outer root sheath of the hair follicle during the late anagen phase of the hair cycle [2].
• Administration of APAP enhanced expression of Mrp2 (1.6-fold), Mrp3 (3.5-fold), and Mrp4 (16-fold) [4].
• Mrp3, however, was induced by PB, diallyl sulfide, trans-stilbene oxide and oltipraz in both wild-type and RXRalpha-/- mice [5].
• Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice [6].

Biological context of Prl2c4

• The size and organization of the five exons in the murine mrp/plf3 gene are very similar to those of members of the prolactin/growth hormone family, confirming that mrp/plf3 is a part of this superfamily [7].
• We also document the production of stable MRP/PLF mRNA generated by transcription of various plasmid constructs containing different portions of the MRP/PLF3 gene after calcium phosphate-mediated transfection into the MEFs [8].
• In conclusion, bile salts themselves cause cholangiocyte apoptosis when absorbed by and retained inside the cell, but this is inhibited by washing out cytotoxic bile salts according to Mrp3, a rescue exporting molecule [9].

Anatomical context of Prl2c4

• MRP3 levels in both HepG2 and g2car-3 cells were induced to a similar extent in the two cell lines by PB but not by TCPOBOP [10].

Associations of Prl2c4 with chemical compounds

• Mrp3, a mitogen-regulated protein/proliferin gene expressed in wound healing and in hair follicles [2].
• However, Mrp3 was equally induced both in wild-type and CAR-/- mice by PB [5].

Analytical, diagnostic and therapeutic context of Prl2c4

• Further, expression of cholangiocyte bile salt transporters (apical sodium-dependent bile salt transporter [Asbt] and multidrug resistance protein 3 [Mrp3]) was examined by RT-PCR and western blotting, and cholangiocyte bile salt uptake was determined using radiolabeled bile salts [9].

References