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Gene Review

Pask  -  PAS domain containing serine/threonine kinase

Mus musculus

Synonyms: Kiaa0135, PAS domain-containing serine/threonine-protein kinase, PAS-kinase, PASKIN, Paskin
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Disease relevance of Pask


High impact information on Pask


Biological context of Pask

  • A recent report suggested that PASKIN mRNA, protein, and kinase activity are increased in pancreatic islet beta-cells under hyperglycemic conditions and that PASKIN is necessary for insulin gene expression [2].
  • Here we show that no 5-bromo-4-chloro-3-indolyl-ss-d-galactopyranoside (X-gal) staining was observed in islet beta-cells derived from Paskin knockout mice, irrespective of the ambient glucose concentration, whereas adenoviral expression of the lacZ gene in beta-cells showed strong X-gal staining [2].
  • We previously generated Paskin knockout mice by targeted replacement of the kinase domain with the beta-geo fusion gene encoding beta-galactosidase reporter activity [2].

Anatomical context of Pask


Associations of Pask with chemical compounds

  • Increasing glucose concentrations resulted in PASKIN-independent induction of insulin mRNA levels and insulin release [2].


  1. Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Katschinski, D.M., Marti, H.H., Wagner, K.F., Shibata, J., Eckhardt, K., Martin, F., Depping, R., Paasch, U., Gassmann, M., Ledermann, B., Desbaillets, I., Wenger, R.H. Mol. Cell. Biol. (2003) [Pubmed]
  2. Glucose-Stimulated Insulin Production in Mice Deficient for the PAS Kinase PASKIN. Borter, E., Niessen, M., Zuellig, R., Spinas, G.A., Spielmann, P., Camenisch, G., Wenger, R.H. Diabetes (2007) [Pubmed]
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