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Gene Review

GOLGA1  -  golgin A1

Homo sapiens

Synonyms: Golgin subfamily A member 1, Golgin-97, MGC33154, golgin-97
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Disease relevance of GOLGA1

  • Here we discuss the potential role and functions of golgin-97 in poxvirus replication and propose two working models [1].
  • Inside the virion, golgin-97 is associated with the insoluble core protein fraction [1].

High impact information on GOLGA1

  • Using a Shiga toxin B fragment (STxB)-based in vitro transport assay, we demonstrated that Golgin-97 plays a role in transport from the endosome to the trans-Golgi network (TGN) [2].
  • The kinetic characterization of inhibition by anti-Golgin-97 antibody in comparison with anti-Syntaxin 16 antibody established that Golgin-97 acts before Syntaxin 16 in endosome-to-TGN transport [2].
  • Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi [3].
  • Endogenous p230 was displaced from the Golgi membranes in transfected cells expressing high levels of GFP fused to the GLD of either p230 or golgin-97, indicating that different GLDs interact with similar membrane determinants [4].
  • CONCLUSION: Golgin-97 is a unique Golgi complex antigen that appears to be a target of SS autoantibodies [5].

Biological context of GOLGA1

  • By analyzing more than 30 mutants of golgin-97 and golgin-245 GRIP domains for their properties of dimerization, interaction with ARF like protein 1 (Arl1)-GTP and Golgi targeting, we found hierarchically organized three-tier interactions governing the Golgi targeting of GRIP domain golgins [6].
  • In the work described here, we demonstrate that a host cell protein residing in the trans-Golgi network membrane, golgin-97, is transported to the sites of virus replication and assembly and becomes incorporated into the virions during poxvirus infection [1].

Anatomical context of GOLGA1


Associations of GOLGA1 with chemical compounds


Physical interactions of GOLGA1

  • Golgin-97 is identified as a selective and essential component of the tubulovesicular carriers transporting E-cadherin out of the TGN [7].

Other interactions of GOLGA1

  • Thus, the GRIP domains of p230/golgin-245 and golgin-97 bind discriminately to distinct membrane subdomains of the TGN [7].
  • Our analysis identified three novel candidate housekeeping genes (CGI-119, GOLGA1, and CTBP1) that could prove useful for normalization across a variety of RNA-based techniques [11].

Analytical, diagnostic and therapeutic context of GOLGA1

  • Western blot analysis showed that the immune rabbit sera recognized a protein of 97 kd (golgin-97), suggesting that the isolated clone contained a partial cDNA [5].
  • Microinjection of Golgin-97 antibody led to the fragmentation of Golgi apparatus and the arrested transport to the Golgi of internalized Cholera toxin B fragment [2].
  • By semi-quantitative immunofluorescence microscopy we found that high level expression of epitope-tagged, GRIP domain-containing fragments of tGolgin-1 or golgin-97 specifically altered the characteristic pericentriolar distribution of TGN integral membrane and coat components [12].
  • Surface plasmon resonance analysis indicates that GRIP domain interacts directly with membrane lipid, partially through the third group of residues such as W744 of golgin-97 [6].


  1. A trans-Golgi Network Resident Protein, golgin-97, Accumulates in Viral Factories and Incorporates into Virions during Poxvirus Infection. Alzhanova, D., Hruby, D.E. J. Virol. (2006) [Pubmed]
  2. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. Lu, L., Tai, G., Hong, W. Mol. Biol. Cell (2004) [Pubmed]
  3. Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi. Lu, L., Hong, W. Mol. Biol. Cell (2003) [Pubmed]
  4. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Kjer-Nielsen, L., Teasdale, R.D., van Vliet, C., Gleeson, P.A. Curr. Biol. (1999) [Pubmed]
  5. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. Griffith, K.J., Chan, E.K., Lung, C.C., Hamel, J.C., Guo, X., Miyachi, K., Fritzler, M.J. Arthritis Rheum. (1997) [Pubmed]
  6. Multilayer Interactions Determine the Golgi Localization of GRIP Golgins. Lu, L., Tai, G., Wu, M., Song, H., Hong, W. Traffic (2006) [Pubmed]
  7. E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97. Lock, J.G., Hammond, L.A., Houghton, F., Gleeson, P.A., Stow, J.L. Traffic (2005) [Pubmed]
  8. N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping. Morissette, G., Moreau, E., C-Gaudreault, R., Marceau, F. Mol. Pharmacol. (2005) [Pubmed]
  9. Possible implication of Golgi-nucleating function for the centrosome. Takatsuki, A., Nakamura, M., Kono, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  10. Infection of human endothelial cells with Bartonella bacilliformis is dependent on Rho and results in activation of Rho. Verma, A., Davis, G.E., Ihler, G.M. Infect. Immun. (2000) [Pubmed]
  11. Identification of novel universal housekeeping genes by statistical analysis of microarray data. Lee, S., Jo, M., Lee, J., Koh, S.S., Kim, S. J. Biochem. Mol. Biol. (2007) [Pubmed]
  12. A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network. Yoshino, A., Bieler, B.M., Harper, D.C., Cowan, D.A., Sutterwala, S., Gay, D.M., Cole, N.B., McCaffery, J.M., Marks, M.S. J. Cell. Sci. (2003) [Pubmed]
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