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Chemical Compound Review

SureCN28560     (2S)-2-amino-3-(3- methylimidazol-4...

Synonyms: AG-K-76098, CHEBI:27596, M9005_SIGMA, HMDB00479, KB-32838, ...
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Disease relevance of C01152


Psychiatry related information on C01152


High impact information on C01152


Chemical compound and disease context of C01152


Biological context of C01152


Anatomical context of C01152

  • Measurements were also made of the steady-state synthesis rate of protein-bound 3-methylhistidine in intestinal smooth muscle in vivo in adult female rats [22].
  • Interstitial 3MH concentration was calculated using the internal reference method from microdialysate samples that were obtained from two microdialysis probes placed in the vastus lateralis [23].
  • To determine whether this delayed onset of actin methylation occurred simultaneously throughout the organism or differed from tissue to tissue, the 3-methylhistidine content of cardiac muscle actin from Day 2 of embryonic life to hatching and of brain actin at Days 9, 11, and 14 were analyzed [24].
  • Rapid analysis of 3-methylhistidine in urine, plasma, muscle and amniotic fluid with a single high-performance liquid chromatographic system but with different ion-pairing reagents [25].
  • In methylation experiments employing the fusion actin in the form of inclusion bodies, 3-methylhistidine is the major product, as is the case when soluble muscle or non-muscle actin is used [26].

Associations of C01152 with other chemical compounds

  • Additional studies revealed that the addition of excess retinol to the perfusion medium (10 i.u./ml) had no significant effect on the rates of 3-methylhistidine release or [3H]phenylalanine incorporation in vitro [27].
  • Excessive vitamin A intake stimulated 3-methylhistidine excretion in vivo and in vitro in both adrenalectomized and sham-operated animals, thus suggesting that the vitamin A-induced acceleration in myofibrillar protein breakdown was not mediated by the adrenals [27].
  • Pretreatment of rats with IL-6 for 6 hr induced fever and increased the release of both tyrosine and 3-methylhistidine by the extensor digitorum longus muscle [28].
  • Plasma albumin, prealbumin, fibronectin and serum urea concentrations, nitrogen balance and 3-methylhistidine release from the leg and its excretion in the urine were measured [29].
  • Body N balance, 3-methylhistidine (MEH) excretion, amino acid (AA) plasma concentration, and fluxes across the leg were investigated both during fasting and during parenteral nutrition of injured patients in order to better understand protein-sparing mechanisms induced by metabolic support in the whole body and in skeletal muscle [30].

Gene context of C01152

  • Urinary 3-methylhistidine excretion correlated with mononuclear cell secretion of both IL-1 beta (P less than 0.05) and prostaglandin E2 (P less than 0.05), supporting the concept that these mononuclear cell products contribute to the regulation of muscle proteolysis [31].
  • There was no relationship between IL-6, nitrogen balance, and 3-methylhistidine excretion [32].
  • Indinavir increased mRNA expression of the ubiquitin ligase MuRF1, but the plasma concentration of 3-methylhistidine remained unaltered [33].
  • Interleukin 6 levels correlated positively with protein turnover (phenylalaninemia) and catabolism (3-methylhistidine/creatinine ratio) and negatively with levels of fibronectin and transthyretin [34].
  • The mean +/- SEM 3-methylhistidine loss for burned patients on the third day was 9.83 +/- 0.82 mumol/kg compared to 3.6 mol/kg for control patients [35].

Analytical, diagnostic and therapeutic context of C01152


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  18. Myofibrillar protein degradation in premature infants with respiratory distress as assessed by 3-methylhistidine and creatinine excretions. Lunyong, V.E., Friedman, Z. Am. J. Clin. Nutr. (1982) [Pubmed]
  19. Myofibrillar protein turnover. Synthesis of protein-bound 3-methylhistidine, actin, myosin heavy chain and aldolase in rat skeletal muscle in the fed and starved states. Bates, P.C., Grimble, G.K., Sparrow, M.P., Millward, D.J. Biochem. J. (1983) [Pubmed]
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  23. Influence of age and resistance exercise on human skeletal muscle proteolysis: a microdialysis approach. Trappe, T., Williams, R., Carrithers, J., Raue, U., Esmarck, B., Kjaer, M., Hickner, R. J. Physiol. (Lond.) (2004) [Pubmed]
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  32. Decreased corticosteroid-binding globulin in burn patients: relationship with interleukin-6 and fat in nutritional support. Bernier, J., Jobin, N., Emptoz-Bonneton, A., Pugeat, M.M., Garrel, D.R. Crit. Care Med. (1998) [Pubmed]
  33. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Hong-Brown, L.Q., Pruznak, A.M., Frost, R.A., Vary, T.C., Lang, C.H. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
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