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Clmp  -  CXADR-like membrane protein

Rattus norvegicus

Synonyms: ACAM, Acam, Adipocyte adhesion molecule, Asam, CAR-like membrane protein, ...
 
 
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Disease relevance of Asam

  • ACAM mRNA was predominantly expressed in WATs in OLETF rats, and increased with the development of obesity until 30 weeks of age, which is when the peak of body mass is reached [1].
  • This protein, which was designated CLMP (coxsackie- and adenovirus receptor-like membrane protein), is composed of 373 amino acids including an extracellular part containing a V- and a C2-type domain, a transmembrane region and a cytoplasmic tail [2].
 

High impact information on Asam

  • Also endogenous CLMP showed association with tight junctions, as analyzed in polarized human CACO-2 cells [2].
  • CLMP mRNA was detected in a variety of both human and mouse tissues and cell lines [2].
  • This suggested a role for CLMP in cell-cell adhesion and indeed, overexpressed CLMP induced aggregation of non-polarized CHO cells [2].
  • In cultured epithelial cells, CLMP was detected in areas of cell-cell contacts [2].
  • Up-regulation of ACAM mRNAs in obesity was also shown in WATs of genetically obese db/db mice, diet-induced obese ICR mice and human obese subjects [1].
 

Biological context of Asam

  • Several stably transfected Chinese-hamster ovary K1 cell lines were established, and the quantification of ACAM mRNA and cell aggregation assay revealed that the degree of homophilic aggregation correlated well with ACAM mRNA expression [1].
 

Anatomical context of Asam

 

Associations of Asam with chemical compounds

  • ACAM, 372 amino acids in total, has a signal peptide, V-type (variable) and C2-type (constant) Ig domains, a single transmembrane segment and a cytoplasmic tail [1].

References

  1. Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. Eguchi, J., Wada, J., Hida, K., Zhang, H., Matsuoka, T., Baba, M., Hashimoto, I., Shikata, K., Ogawa, N., Makino, H. Biochem. J. (2005) [Pubmed]
  2. CLMP, a novel member of the CTX family and a new component of epithelial tight junctions. Raschperger, E., Engstrom, U., Pettersson, R.F., Fuxe, J. J. Biol. Chem. (2004) [Pubmed]
 
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